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Cited by 48Systemic Sclerosis and Related DiseasesThermoregulation and physiological responsesInfrared Thermography in Medicine

Impaired Thermoregulation in Raynaud's Phenomenon

Greenstein, D., Gupta, N.K., Martin, P., Walker, D.R., Kester, R.C.·1995·Angiology
DOI 10.1177/000331979504600707
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Abstract

In an attempt to examine the role of the thermoregulatory apparatus in the etiology of Raynaud's phenomenon (RP), the authors exposed 15 women with RP and 12 controls to central body cooling and central body warming. Subjects were placed in an environ mental chamber at 25°C. Their right hand was placed in an annex of the chamber, which was insulated from the main chamber and maintained at a constant temperature of 25°C throughout the experiment. Blood flow was measured in the digits of the right hand by venous occlusion strain gauge plethysmography and skin thermometry. Body temperature was measured with an oral thermometer. The temperature of the chamber was then increased to 35°C and then reduced to 13°C for twenty-five minutes with measurements repeated. Following this period patients were rewarmed in an ambient temperature of 35°C for twenty minutes. Results: subjects with RP had significantly lower blood flow at all stages of the test; moreover, their digital rewarming response following central cooling was considerably prolonged when compared with controls. Body temperature was lower and dropped significantly more in the RP group following the cold challenge. The authors conclude that subjects with RP have an impaired thermoregulatory mechanism. This may partially explain cold sensitivity.

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  • Both Parkinson's disease and Raynaud's syndrome are marked by impaired thermoregulation, linked in Parkinson's to alpha-synuclein pathology in the CNS and in Raynaud's to sympathetic nervous system and α2C adrenoreceptor dysregulation in the small blood vessels of the digits.

    “However, both of these diseases are marked by impaired thermoregulation39,40, linked in Parkinson’s to alpha-synuclein pathology in the CNS40 and in Raynaud’s to sympathetic nervous system and α2C adrenoreceptor dysregulation in the small blood vessels of the digits41.”

    From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [40]

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Authors
Greenstein, D., Gupta, N. K., Martin, P., Walker, D. R., & Kester, R. C.
Affiliations
Seacroft Hospital (GB)
ORCID
Gupta, N.K.
Venue
Angiology
Publisher
SAGE Publications
Published
1995-07
Volume
46
Issue
7
Pages
603-611
ISSN
  • 0003-3197 (ISSN-L)
  • 1940-1574
DOI
10.1177/000331979504600707
OpenAlex
W2010796314
Cited by
48
References
14
Citations by year
2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2012: 1
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Angiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Infrared Thermography in Medicine
Keywords
Raynaud's phenomenon, thermoregulation, cold sensitivity, digital blood flow, cold challenge, body temperature, skin temperature, venous occlusion plethysmography
MeSH terms
Adult, Body Temperature, Body Temperature Regulation, Cold Temperature, Female, Fingers, Hot Temperature, Humans, Male, Middle Aged, Plethysmography, Raynaud Disease, Regional Blood Flow, Skin Temperature, Statistics, Nonparametric

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