Mode of neural control mediating rat tail vasodilation during heating
Abstract
The purpose of this investigation was to delineate the mode of efferent neural control mediating rat tail vasodilation during body heating. Tail blood flow (venous occlusion plethysmography), tail skin temperature over the ventral vascular bundle, and arterial pressure were measured in Sprague-Dawley rats anesthetized with pentobarbital sodium (45 mg/kg). Three protocols were followed: anesthesia of the lumbar sympathetic chain, bilateral lumbar sympathectomy, and sympathetic nerve stimulation during varying degrees of alpha-adrenergic receptor blockade. Mean tail blood flow and tail vascular conductance (TVC) during body heating were 40.3 +/- 8.7 ml X 100 ml-1 X min-1 and 39.2 +/- 9.2 ml X 100 ml-1 X min-1 X 100 mmHg-1, respectively. Interruption of sympathetic nerve activity by sympathetic nerve anesthetization or sympathectomy during heat stress caused a nonsignificant increase in TVC to 112.7 +/- 1.8 and 121.12 +/- 6.3%, respectively, of the values achieved with body heating. Sympathectomy performed in normothermic animals that had recovered from prior heating caused an increase in TVC to 128.4 +/- 14.0% of the levels achieved during the previous heating period. In addition, sympathetic nerve stimulation after complete alpha-adrenergic receptor blockade failed to produce a vasodilation [control TVC = 10.2 +/- 3.9 vs. TVC during nerve stimulation = 10.4 +/- 3.9 (P greater than 0.05)]. It is concluded that the increase in TVC during body heating occurs solely via a reduction in vasoconstrictor nerve activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These data show a vasodilator effect of NK3R MnPO neuron activation in neutral ambient temperatures, that is suppressed in the subneutral environment.
“Because vasodilatation in the rat is accomplished by inhibiting vasoconstriction (O’Leary et al., 1985), these data show a vasodilator effect of NK3R MnPO neuron activation in neutral ambient temperatures, that is suppressed in the subneutral environment.”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as O’Leary et al., 1985
Cited by
Sorted by citations
Rácz, I., & Zimmer, A. (2006) · doi:10.1002/9783527611942.ch9 · Cited by 1,659 · see citing works
Le Bars, D., Gozariu, M., & Cadden, S. W. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01514-x · Cited by 1,459 · see citing works
Central neural pathways for thermoregulation
Shaun, F. M. (2010) · Frontiers in bioscience · doi:10.2741/3677 · Cited by 658 · see citing works
“In contrast, rats do not appear to have a cholinergic sympathetic vasodilator system (106) and thus the thermoregulatory control of blood flow to the rat tail is primarily dependent on the level of CVC sympathetic outflow (107).”
BackgroundRance, N. E., Dacks, P. A., Mittelman-Smith, M. A., Romanovsky, A. A., & Krajewski-Hall, S. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.003 · Cited by 380 · see citing works
“Because vasodilatation in the rat is accomplished by inhibiting vasoconstriction (O’Leary et al., 1985), these data show a vasodilator effect of NK3R MnPO neuron activation in neutral ambient temperatures, that is suppressed in the subneutral environment.”
BackgroundChanges in cutaneous and body temperature during and after conditioned fear to context in the rat
Vianna, D. M. L., & Carrive, P. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04073.x · Cited by 327 · see citing works
“Skin temperature depends on skin blood flow and sympathetic vasoconstrictor tone in skin arteries (Hertzman, 1953; Felder et al., 1954; Rand et al., 1965; Hales et al., 1978; O’Leary et al., 1985; Janig & McLachlan, 1992; Owens et al., 2002; Blessing & Seaman, 2003).”
BackgroundCardiovascular Adjustments to Heat Stress
Johnson, J. M., & Proppe, D. W. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp040111 · Cited by 302 · see citing works
Self-citationSmith, J. E., Jansen, A. S. P., Gilbey, M. P., & Loewy, A. D. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01437-6 · Cited by 224 · see citing works
Expression of melatonin receptors in arteries involved in thermoregulation.
Viswanathan, M. N., Laitinen, J. T., & Saavedra, J. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6200 · Cited by 204 · see citing works
Krause, D. N., Barrios, V. E., & DUCKLES, S. P. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00028-j · Cited by 111 · see citing works
Role of the medullary raphé in thermoregulatory vasomotor control in rats
Tanaka, M., Nagashima, K., McAllen, R. M., & Kanosue, K. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012989 · Cited by 107 · see citing works
Thermoregulatory Control of Sympathetic Fibres Supplying the Rat's Tail
Owens, N. C., Ootsuka, Y., Kanosue, K., & McAllen, R. M. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.023770 · Cited by 83 · see citing works
“The vasoconstrictor supply to the tail thereby plays an important role in thermoregulation (Rand et al. 1965; O’Leary et al. 1985).”
BackgroundControl of cutaneous blood flow by central nervous system
Ootsuka, Y., & Tanaka, M. (2015) · Temperature · doi:10.1080/23328940.2015.1069437 · Cited by 79 · see citing works
“sympathetic vasoconstrictor nerves.(12,13) There is no consensus about the presence of a sympathetic vasodilator innervation in laboratory animals.”
BackgroundCapsaicin activates heat loss and heat production simultaneously and independently in rats
Kobayashi, A., Osaka, T., Namba, Y., Inoue, S., Lee, T. H., & Kimura, S. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r92 · Cited by 80 · see citing works
“Large increases in tail blood flow in rats occur via reduction in sympathetic vasoconstrictor tone of the skin (20).”
BackgroundCentral Mechanisms for Thermoregulation in a Hot Environment
Nagashima, K. (2006) · Industrial Health · doi:10.2486/indhealth.44.359 · Cited by 76 · see citing works
Dacks, P. A., Krajewski, S. J., & Rance, N. E. (2011) · Endocrinology · doi:10.1210/en.2011-1492 · Cited by 70 · see citing works
Tiesjema, B., Adan, R. A. H., Luijendijk, M. C. M., Kalsbeek, A., & la Fleur, S. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3280-07.2007 · Cited by 70 · see citing works
Integrating Competing Demands of Osmoregulatory and Thermoregulatory Homeostasis
McKinley, M. J., Martelli, D., Pennington, G. L., Trevaks, D., & McAllen, R. M. (2018) · Physiology · doi:10.1152/physiol.00037.2017 · Cited by 67 · see citing works
“the tail blood vessels (75), and spread saliva on”
BackgroundHale, M. W., Dady, K., Evans, A. K., & Lowry, C. A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.012 · Cited by 65 · see citing works
Roles of two preoptic cell groups in tonic and febrile control of rat tail sympathetic fibers
Tanaka, M., McKinley, M. J., & McAllen, R. M. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91010.2008 · Cited by 60 · see citing works
“Blood flow to glabrous skin such as that of the tail and paw of the rat is important for thermoregulation because it is a major determinant of heat dissipation to the environment (3, 23).”
Comparison between two rat sympathetic pathways activated in cold defense
Ootsuka, Y., & McAllen, R. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00850.2005 · Cited by 59 · see citing works
Effects of fasting on thermoregulatory processes and the daily oscillations in rats
Nagashima, K., Nakai, S., Matsue, K., Konishi, M., Tanaka, M., & Kanosue, K. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00515.2002 · Cited by 58 · see citing works
“In addition, tail blood flow is controlled by sympathetic nerve activity (14, 19).”
BackgroundSympathetic activity recorded from the rat caudal ventral artery in vivo.
Johnson, C. D., & Gilbey, M. P. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020145 · Cited by 58 · see citing works
Impaired Thermoregulation in Raynaud's Phenomenon
Greenstein, D., Gupta, N. K., Martin, P., Walker, D. R., & Kester, R. C. (1995) · Angiology · doi:10.1177/000331979504600707 · Cited by 48 · see citing works
Mediators involved in the febrile response induced by Tityus serrulatus scorpion venom in rats
Pessini, A. C., Santos, D. R., Arantes, E. C., et al. (2006) · Toxicon · doi:10.1016/j.toxicon.2006.07.006 · Cited by 47 · see citing works
“The rat’s tail serves as a variable heat exchanger (O’Leary et al., 1985; Gordon et al., 2002), since its blood flow is regulated by the activity of sympathetic vasoconstrictor nerves, specifically controlled by neurones of the raphé”
BackgroundWanner, S. P., Prímola‐Gomes, T. N., Pires, W., Guimarães, J. B., Hudson, A. S. R., Kunstetter, A. C., Fonseca, C. G., Drummond, L. R., Damasceno, W. C., & Teixeira-Coelho, F. (2015) · Temperature · doi:10.1080/23328940.2015.1119615 · Cited by 46 · see citing works
“The tail surface is the most common site for measuring the skin temperature, and many investigators associate this temperature with tail-skin blood flow.(47,81) The evaporative heat loss from tail skin is negligible, and, therefore, water evaporation does not influence the TTAIL value in a running rat.”
BackgroundEndothelin-1 as a central mediator of LPS-induced fever in rats
Fabricio, A. S. C., Rae, G. A., D’Orléans-Juste, P., & de Souza, G. E. P. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.037 · Cited by 45 · see citing works
Central serotonin attenuates LPS-induced systemic inflammation
Mota, C. M. D., Rodrigues-Santos, C., Fernández, R. A. R., Carolino, R. O. G., Antunes‐Rodrigues, J., Anselmo-Franci, J. A., & Branco, L. G. S. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.010 · Cited by 44 · see citing works
Control of the Cutaneous Circulation by the Central Nervous System
Blessing, W. W., McAllen, R. M., & McKinley, M. J. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150034 · Cited by 53 · see citing works
Kanashiro, A., Pessini, A. C., Machado, R. R., Malvar, D. D. C., Aguiar, F. A., Soares, D. M., do Vale, M. L., & de Souza, G. E. P. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90527.2008 · Cited by 41 · see citing works
“The reduction in tail skin temperature was reflected by the reduction of heat loss index (HLI; 48), indicating vasoconstriction of the local (tail) vascular bed with the intention of retaining heat, in response to the increased hypothalamic set point (44).”
Independent vasomotor control of rat tail and proximal hairy skin
Tanaka, M., Ootsuka, Y., McKinley, M. J., & McAllen, R. M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.131292 · Cited by 40 · see citing works
“By contrast, hairless areas such as the tail and plantar surfaces can dissipate heat much more effectively when their vasoconstrictor tone is removed (O’Leary et al. 1985; Gordon, 1990), due to good surface conduction and blood flow increases of up to 400% (Rendell et al. 1998).”
BackgroundA crucial role for IL-6 in the CNS of rats during fever induced by the injection of live E. coli
Soares, D. D. M., Figueiredo, M. J., Martins, J. M., Machado, R. R., Sorgi, C. A., Faccioli, L. H., Alves-Filho, J. C., Cunha, F. Q., & de Souza, G. E. P. (2011) · Medical Microbiology and Immunology · doi:10.1007/s00430-011-0204-3 · Cited by 39 · see citing works
“Vasoconstriction of the local vascular bed is aimed at heat retention and is a characteristic feature of the febrile response [41].”
BackgroundWanner, S. P., Guimarães, J. B., Rodrigues, L. O. C., Marubayashi, U., Coimbra, C. C., & Lima, N. R. V. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.03.004 · Cited by 38 · see citing works
The vascular reactivity of melatonin
Monroe, K. K., & Watts, S. W. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00090-6 · Cited by 36 · see citing works
Hosono, T., Chen, X.-M., Miyatsuji, A., Yoda, T., Yoshida, K., Yanase-Fujiwara, M., & Kanosue, K. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.5.r1341 · Cited by 32 · see citing works
“Tail vasomotor activity of the rat is controlled only by sympathetic nerves (17).”
BackgroundPlasma hyperosmolality and arterial pressure regulation during heating in dehydrated and awake rats
Nakajima, Y., Nosé, H., & Takamata, A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1703 · Cited by 31 · see citing works
“They also reported that TVC was regulated solely by the sympathetic vasoconstrictor (28).”
BackgroundThe influence of the ventrolateral medulla on thermoregulatory circulations in the rat
Key, B. J., & Wigfield, C. C. (1994) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)90162-7 · Cited by 31 · see citing works
CCR1 and CCR5 chemokine receptors are involved in fever induced by LPS (E. coli) and RANTES in rats
Machado, R. R., Soares, D. D. M., Proudfoot, A. E. I., & de Souza, G. E. P. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.054 · Cited by 31 · see citing works
Gilbey, M. P. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03414.x · Cited by 29 · see citing works
The role of α2‐adrenoceptors in the vasculature of the rat tail
Redfern, W. S., MacLean, M. R., Clague, R. U., et al. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb14963.x · Cited by 29 · see citing works
Soares, D. D. M., Machado, R. R., Yamashiro, L. H., Melo, M. C. C., & de Souza, G. E. P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.069 · Cited by 28 · see citing works
“The rat's tail serves as a variable heat exchanger (O'Leary et al., 1985) because its blood flow is regulated by the activity of sympathetic vasoconstrictor nerves specifically controlled by neurons of the raphémagnus/pallidum nucleus (Blessing and Nalivaiko, 2001).”
Soares, D. D. M., Veiga-Souza, F. H., Fabricio, A. S. C., Miñano, F. J., & de Souza, G. E. P. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.026 · Cited by 28 · see citing works
Increased brain l ‐arginine availability facilitates cutaneous heat loss induced by running exercise
Wanner, S. P., Leite, L. H. R., Guimarães, J. B., & Coimbra, C. C. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12407 · Cited by 27 · see citing works
“In contrast to the hairy (non-glabrous) skin of humans, the tail skin vessels of rats are only innervated by a noradrenergic vasoconstrictor system, and there is no evidence of the existence of an active vasodilator system innervating this cutaneous bed.(26,42) This pattern of neural control found in the rat’s tail is…”
BackgroundBitar, N. E., Pollin, B., Karroum, E. G., Pincedé, I., Mouraux, A., & Bars, D. L. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00721.2013 · Cited by 23 · see citing works
Efferent thermoregulatory pathways regulating cutaneous blood flow and sweating
McAllen, R. M., & McKinley, M. J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00018-7 · Cited by 24 · see citing works
Activation of the central cholinergic pathway increases post-exercise tail heat loss in rats
Prímola‐Gomes, T. N., Pires, W., Rodrigues, L. O. C., Coimbra, C. C., Marubayashi, U., & Lima, N. R. V. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.042 · Cited by 24 · see citing works
Key, B. J., & Wigfield, C. C. (1992) · Neuropharmacology · doi:10.1016/0028-3908(92)90032-k · Cited by 24 · see citing works
The lumbar preganglionic sympathetic supply to rat tail and hindpaw
Rathner, J. A., & McAllen, R. M. (1998) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(98)00014-9 · Cited by 22 · see citing works
Pires, W., Wanner, S. P., Lima, M. R. M., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.110 · Cited by 21 · see citing works
“Moreover, the increase of Tcore during exercise or fever depends on the activation of differentmechanismsofheat production: fever is a consequence of brown adipose tissue thermogenesis (Ootsuka et al., 2008), while heat is generated in the contracting muscles during exercise (Sonne and Galbo, 1980).”
Ryan, K. L., Cortez, D. S., Dick, E. J., et al. (2006) · Resuscitation · doi:10.1016/j.resuscitation.2005.11.008 · Cited by 21 · see citing works
Arterial Baroreceptor Regulation of Peripheral Resistance and of Cardiac Performance
Scher, A. M., O’Leary, D. S., & Sheriff, D. D. (1991) · Springer eBooks · doi:10.1007/978-3-642-76366-3_4 · Cited by 21 · see citing works
Self-citationWanner, S. P., Guimarães, J. B., Pires, W., Guardia, R. B. L., Haibara, A. S., Marubayashi, U., Coimbra, C. C., & Lima, N. R. V. (2010) · Physiological Research · doi:10.33549/physiolres.931649 · Cited by 20 · see citing works
The Influence of Chronic Sympathectomy on Cutaneous Blood Flow in the Rat Tail.
Yanagiya, Y., YOSHIMURA, R., Hori, M., et al. (1999) · Journal of Veterinary Medical Science · doi:10.1292/jvms.61.795 · Cited by 20 · see citing works
Taylor, N. A. S., & Gordon, C. J. (2019) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2019.08.003 · Cited by 19 · see citing works
Adrenoceptor and local modulator control of cutaneous blood flow in thermal stress
Roberts, M., Rivers, T., Oliveria, S. F., et al. (2002) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(01)00501-3 · Cited by 19 · see citing works
Lima, P. M. A., Santiago, H. P., Szawka, R. E., & Coimbra, C. C. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.09.002 · Cited by 18 · see citing works
Neural cell-types and circuits linking thermoregulation and social behavior
Rogers, J. F., Vandendoren, M., Prather, J. F., Landen, J. G., Bedford, N. L., & Nelson, A. C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105667 · Cited by 20 · see citing works
“In humans, active heat loss is achieved via sympathetic cholinergic cutaneous vasodilation (Charkoudian, 2010), whereas, in rodents, vasodilation is often mediated by release of tonic sympathetic vasoconstriction (O ’ Leary et al., 1985; Wanner et al., 2007).”
Lima, M. R. M., Pires, W., Fonseca, I. A. T., Joviano‐Santos, J. V., Ferreira, A. J., Coimbra, C. C., Lima, N. R. V., & Wanner, S. P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00074 · Cited by 17 · see citing works
“, 2013); this vasodilation results from the chemical neurolysis of sympathetic innervation, which promotes the tonic vasoconstriction of cutaneous vessels (O’Leary et al., 1985).”
BackgroundSegmental origin of sympathetic preganglionic neurones regulating the tail circulation in the rat
Smith, J. E., & Gilbey, M. P. (1998) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(97)00124-0 · Cited by 16 · see citing works
Figueiredo, M. J., Fabricio, A. S. C., Machado, R. R., Melo, M. C. C., Soares, D. D. M., & Veiga-Souza, F. H. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.07.167 · Cited by 15 · see citing works
Coupling the in vivo performance to the in vitro characterization of PLGA microparticles
Otte, A., Damen, F. W., Goergen, C. J., & Park, K. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120738 · Cited by 14 · see citing works
“While thermal regulation through tail-skin vasodilation for heat loss or vasoconstriction for heat retention will occur to account for the environmental differences (Grant, 1963; O’Leary et al., 1985), oscillating temperatures may supply enough energy to the microparticle to result in structural rearrangement, i.”
BackgroundSoares, D. D. M., Ott, D., Melo, M. C. C., de Souza, G. E. P., & Roth, J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.08.005 · Cited by 13 · see citing works
Entanglement between thermoregulation and nociception in the rat: the case of morphine
Bitar, N. E., Pollin, B., Karroum, E. G., Pincedé, I., & Bars, D. L. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00482.2016 · Cited by 11 · see citing works
The relevance of kalikrein-kinin system via activation of B 2 receptor in LPS-induced fever in rats
Soares, D. D. M., Santos, D. R., Rummel, C. D., Ott, D., Melo, M. C. C., Roth, J., Calixto, J. Β., & de Souza, G. E. P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.019 · Cited by 13 · see citing works
Lumbar Sympathectomy Increases Blood Flow in a Dog Model of Chronic Cauda Equina Compression
Onda, A., Yabuki, S., Iwabuchi, M., et al. (2004) · Journal of Spinal Disorders & Techniques · doi:10.1097/01.bsd.0000112088.85112.62 · Cited by 13 · see citing works
“The vasodilatation is derived by -adrenergic inhibition and induction of endothelium-derived nitric oxide, and thereby these two factors have an important role in modulating blood flow with a balance between them.(25,26) On the other hand, it has been reported that a decrease of the synthesis of nitric oxide in vascul…”
BackgroundEvidence that exercise-induced heat storage is dependent on adrenomedullary secretion
Rodrigues, A. G., Lima, N. R. V., Coimbra, C. C., & Marubayashi, U. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.02.012 · Cited by 13 · see citing works
Chronic sympathectomy of the caudal artery delays cutaneous heat loss during passive heating
Lima, M. R. M., Pires, W., Fonseca, I. A. T., Fonseca, C. G., Martinelli, P. M., Wanner, S. P., & Lima, N. R. V. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.01.013 · Cited by 12 · see citing works
Local response to cold in rat tail after spinal cord transection
Kalinčík, T., Jozefcikova, K., Waite, P. M. E., et al. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00095.2009 · Cited by 11 · see citing works
“This role is mediated through its vasculature: the vasoconstrictor tone of the tail vasculature is controlled by sympathetic vasomotor fibers (31, 33).”
BackgroundWhyte, D. G., & Johnson, A. K. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00524.2004 · Cited by 11 · see citing works
Arterial baroreflex modulation of heat-induced vasodilation in the rabbit ear
Ryan, K. L., Taylor, W. F., & BISHOP, V. S. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.6.2091 · Cited by 11 · see citing works
Self-citationA newly discovered behavior (‘tail-belting’) among wild rodents in sub zero conditions
Stryjek, R., Parsons, M. H., & Bębas, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-01833-y · Cited by 10 · see citing works
Ijima, E., Kodera, S., Hirata, A., et al. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1225896 · Cited by 9 · see citing works
“Step 3, which was explained as model-2, is also shown in the proportional relationship between BF and temperature in the rat tail directly (36) and indirectly (37).”
BackgroundControl of the Cutaneous Circulation by the Central Nervous System
Blessing, W., McAllen, R., & Mckinley, M. (2016) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2016.tb00711.x · Cited by 39 · see citing works
“In rats, a thorough study found no functional evidence for sympathetic vasodilator nerves in the tail vascular bed (236), so that neurally mediated increases in tail blood flow occur solely by withdrawal of sympathetic vasoconstrictor nerve activity.”
Dietary Protein Modulates Circadian Changes in Core Body Temperature and Metabolic Rate in Rats
Yamaoka, I., Nakayama, M., Miki, T., YOKOYAMA, T., & Takeuchi, Y. (2008) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.rp006707 · Cited by 8 · see citing works
“Increased SNS activity decreases blood flow in the rat tail [32, 33], a crucial site for heat loss regulation [34], implying that the absence of dietary protein also contributes to the suppression of the heat loss mechanism and consequently increases Tb.”
BackgroundGrajales‐Reyes, J. G., Chen, B., Meseguer, D., & Schneeberger, M. (2024) · Physiology · doi:10.1152/physiol.00034.2023 · Cited by 6 · see citing works
Fenfluramine-induced hypothermia is associated with cutaneous dilation in conscious rats
Subramanian, S., & Vollmer, R. R. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.009 · Cited by 6 · see citing works
Raphe obscurus neurons participate in thermoregulation in rats
Ulhôa, M. A., da Silva, N. F., Pires, J. G. P., et al. (2013) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20130010 · Cited by 6 · see citing works
Hale, M. W., Lukkes, J. L., Dady, K. F., Kelly, K. J., Paul, E. D., Smith, D. G., Heinze, J. D., Raison, C. L., & Lowry, C. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.029 · Cited by 6 · see citing works
“ambient temperature of 22 oC, the fluoxetine-induced hypothermia was associated with increased tail and foot temperature [47], suggesting that fluoxetine may engage thermoregulatory cooling systems [48].”
Altered tail-skin temperature responsiveness in streptozotocin-induced diabetic rats
Katovich, M. J., & Sninsky, C. A. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90719-3 · Cited by 6 · see citing works
Ambient temperature effects on thermoregulation and endurance in anticholinesterase-treated rats
Matthew, C. B. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90169-4 · Cited by 6 · see citing works
The Rat Tail as a Model Organ for Peripheral Vasodilation
Tsuchiya, K. (2001) · Springer eBooks · doi:10.1007/978-4-431-67035-3_22 · Cited by 5 · see citing works
Cutaneous sympathetic motor rhythms during a fever-like response induced by prostaglandin E1
Collins, D. R., KORSAK, A. S., & Gilbey, M. P. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00572-3 · Cited by 5 · see citing works
Quelle est la validité conceptuelle des tests et modèles animaux de douleurs ?
Bars, D. L., Pollin, B., & Plaghki, L. (2012) · Douleur et Analgésie · doi:10.1007/s11724-012-0281-4 · Cited by 4 · see citing works
Cardiovascular Adjustments to Heat Stress
Johnson, J. M., & Proppe, D. W. (1994) · Comprehensive physiology · doi:10.1002/j.2040-4603.1994.tb01157.x · Cited by 3 · see citing works
“Modulation of vasoconstrictor activity appears to be the sole neurogenic mechanism for the cutaneous vascular response to heat stress in the rat tail (79, 184) and the baboon hindlimb (250, 271).”
Self-citationDouleur et thermorégulation. La thermorégulation chez l’animal
Paris-Seine, N., Bitar, N. E., & Bars, D. L. (2015) · Douleur et Analgésie · doi:10.1007/s11724-015-0437-9 · Cited by 3 · see citing works
A Meta-Analysis of Cardiovascular Adaptive Responses to Temperature Variations in Normotensive Rats
Владимировна, К. Н., Щербак, Н. С., Плисс, М. Г., Tsyrlin, V. A., & Galagudza, M. M. (2021) · BIOPHYSICS · doi:10.1134/s0006350921060099 · Cited by 3 · see citing works
Noradrenaline can restore decreased neurogenic vasoreactivity
Karachentseva, O. V., Yartsev, V. N., & Дворецкий, Д. П. (2009) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-009-9113-y · Cited by 3 · see citing works
“The tail artery in rats is known to have an indirect role in thermoregulation, producing significant changes in heat loss as a result of changes in the diameter of the vessel [18, 25], while the efficiency of neurogenic stimulation decreases when temperature decreases [12].”
BackgroundWestphal, K. A., & Richardson, D. R. (1992) · AGE · doi:10.1007/bf02434906 · Cited by 3 · see citing works
Stryjek, R., Parsons, M. H., & Bębas, P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.12.439224 · Cited by 3 · see citing works
Durkot, M. J., Francesconi, R., & Hubbard, R. W. (1992) · Journal of Thermal Biology · doi:10.1016/0306-4565(92)90027-d · Cited by 2 · see citing works
Haley, C. D., Gordon, C. J., Taylor, N. A. S., et al. (2004) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2004.08.055 · Cited by 2 · see citing works
Funk, E. R., Curry, C., Shier, D. M., et al. (2026) · Science Advances · doi:10.1126/sciadv.adz5059 · Cited by 1 · see citing works
Peripheral vascular responses to heat stress after hindlimb suspension
Looft‐Wilson, R. C., & GISOLFI, C. V. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200207000-00011 · Cited by 1 · see citing works
Douleur et thermorégulation. La région bulbaire rostroventrale
Bitar, N. E., & Bars, D. L. (2016) · Douleur et Analgésie · doi:10.1007/s11724-016-0465-4 · Cited by 1 · see citing works
“Le contrôle du flux sanguin vers la queue du rat dépend principalement du tonus sympathique vasoconstricteur cutané [52] sans aucune contribution d’une composante parasympathique [53].”
BackgroundCentral losartan administration increases cardiac workload during aerobic exercise
Leite, L. H. R., Santiago, H. P., de Lima, D. C., et al. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101960 · Cited by 1 · see citing works
Vasoconstriction induced by beta-adrenergic antagonist in the tail of chronic spinal rats
Tsuchiya, K., & Kosaka, M. (1995) · 熱帯医学 Tropical medicine · Cited by 1 · see citing works
A rat model to evaluate the pesticide permeability and stress effects of protective clothing
You, K.-S., Lee, M.-H., & Park, K. H. (2005) · Toxicology and Industrial Health · doi:10.1191/0748233705th214oa · Cited by 1 · see citing works
“This responses in arterial pressure may be related to the participation of compensatory vasodilation caused by the high body temperature (O’Leary et al ., 1985; Wright et al ., 1978) in subjects wearing protective clothing.”
BackgroundKarachentseva, O. V., Yartsev, V. N., Dvoretsky, D. P., & Zhdanova, I. V. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01472.x · Cited by 1 · see citing works
T (tail)-rhythm oscillators: principles of nervous control of the vasculature revealed?
Smith, J. E. (2001) · Autonomic Neuroscience · doi:10.1016/s1566-0702(01)00237-5 · Cited by 1 · see citing works
Tsuchiya, K., Ohta, H., Ozaki, M., et al. (1988) · Institutional Repositories DataBase (IRDB) · Cited by 1 · see citing works
Mammalian thermoregulation: species differences.
Brewer, N. R., & Cruise, L. J. (2000) · PubMed · Cited by 1 · see citing works
- Authors
- O'Leary, D. S., Johnson, J. M., & Taylor, W. F.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1985-11-01
- Volume
- 59
- Issue
- 5
- Pages
- 1533-1538
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2394598000
- Cited by
- 104
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL20663)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- body heating, sympathetic nervous system, lumbar sympathectomy, sympathetic activation, alpha-adrenergic blockade, tail blood flow, heat stress, skin blood flow
- MeSH terms
- Animals, Body Temperature Regulation, Hot Temperature, Male, Neurons, Efferent, Rats, Inbred Strains, Skin, Sympathetic Nervous System, Tail, Vasodilation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
