Cited by 75Circadian rhythm and melatoninSleep and related disordersSleep and Wakefulness Research

Melatonin treatment in adolescents with delayed sleep phase syndrome

Szeinberg, Amir, Borodkin, Katy, Dagan, Yaron·2006·Clinical Pediatrics

Abstract

This retrospective study describes the effects of long-term treatment with melatonin in 33 adolescents (age range, 10-18 years) with delayed sleep phase syndrome (DSPS). Patients were treated with oral melatonin, 3 to 5 mg/day for an average period of 6 months. During the treatment, sleep onset was advanced and sleep duration was longer. Treatment was also associated with a decrease in the proportion of patients reporting school difficulties. No adverse effects of melatonin were noted. This study indicates that long-term treatment with melatonin can be beneficial for adolescents with DSPS in terms of sleep-wake schedule and school performance.

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Crossref · 10.1177/0009922806294218

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Correction of delayed phase by melatonin has been demonstrated to have antidepressant effects in adults and improves school attendance in adolescents; effects on alcohol and drug use remain unexamined.

    “Notably, correction of delayed phase by melatonin has been demonstrated to have antidepressant effects in adults (Rahman, Kayumov, & Shapiro, 2010) and improves school attendance in adolescents (Szeinberg et al., 2006); effects on alcohol and drug use remain unexamined.”

    From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Szeinberg et al., 2006

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Authors
Szeinberg, A., Borodkin, K., & Dagan, Y.
Affiliations
  • Sheba Medical Center (IL)
  • Tel Aviv University (IL)
Venue
Clinical Pediatrics
Published
2006-11
Volume
45
Issue
9
Pages
809-818
ISSN
  • 0009-9228 (ISSN-L)
  • 1938-2707
OpenAlex
W2138776059
Cited by
75
References
48
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 10 · 2013: 2 · 2012: 3
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
melatonin, delayed sleep phase syndrome, adolescents, circadian rhythm sleep disorders, sleep onset timing, sleep duration, academic performance, long-term treatment, adverse effects
MeSH terms
Administration, Oral, Adolescent, Age Factors, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Circadian Rhythm, Female, Follow-Up Studies, Humans, Israel, Male, Melatonin, Psychomotor Performance, Research Design, Retrospective Studies, Sleep, Time Factors, Wakefulness, Case-Control Studies, Treatment Outcome, Sleep Disorders, Circadian Rhythm

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