Melatonin treatment in adolescents with delayed sleep phase syndrome
Abstract
This retrospective study describes the effects of long-term treatment with melatonin in 33 adolescents (age range, 10-18 years) with delayed sleep phase syndrome (DSPS). Patients were treated with oral melatonin, 3 to 5 mg/day for an average period of 6 months. During the treatment, sleep onset was advanced and sleep duration was longer. Treatment was also associated with a decrease in the proportion of patients reporting school difficulties. No adverse effects of melatonin were noted. This study indicates that long-term treatment with melatonin can be beneficial for adolescents with DSPS in terms of sleep-wake schedule and school performance.
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Correction of delayed phase by melatonin has been demonstrated to have antidepressant effects in adults and improves school attendance in adolescents; effects on alcohol and drug use remain unexamined.
“Notably, correction of delayed phase by melatonin has been demonstrated to have antidepressant effects in adults (Rahman, Kayumov, & Shapiro, 2010) and improves school attendance in adolescents (Szeinberg et al., 2006); effects on alcohol and drug use remain unexamined.”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Szeinberg et al., 2006
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Sleep and circadian contributions to adolescent alcohol use disorder
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- Authors
- Szeinberg, A., Borodkin, K., & Dagan, Y.
- Affiliations
- Sheba Medical Center (IL)
- Tel Aviv University (IL)
- Venue
- Clinical Pediatrics
- Publisher
- SAGE Publications
- Published
- 2006-11
- Volume
- 45
- Issue
- 9
- Pages
- 809-818
- ISSN
- 0009-9228 (ISSN-L)
- 1938-2707
- OpenAlex
- W2138776059
- Cited by
- 75
- References
- 48
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 10 · 2013: 2 · 2012: 3
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- melatonin, delayed sleep phase syndrome, adolescents, circadian rhythm sleep disorders, sleep onset timing, sleep duration, academic performance, long-term treatment, adverse effects
- MeSH terms
- Administration, Oral, Adolescent, Age Factors, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Circadian Rhythm, Female, Follow-Up Studies, Humans, Israel, Male, Melatonin, Psychomotor Performance, Research Design, Retrospective Studies, Sleep, Time Factors, Wakefulness, Case-Control Studies, Treatment Outcome, Sleep Disorders, Circadian Rhythm
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