The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Acute-phase Inflammatory Response to Periodontal Disease in the US Population
Abstract
Moderate elevation of serum C-reactive protein (CRP) is a risk factor for cardiovascular disease among apparently healthy individuals, although factors that create this inflammatory response in the absence of systemic illness have not been clarified. This study aimed to: (1) evaluate associations among periodontal disease, established risk factors for elevated CRP, and CRP levels within the US population; and (2) determine whether total tooth loss is associated with reduced CRP. Data were obtained from the third National Health and Nutrition Examination Survey. A random sample of the US population was interviewed in their homes and examined at mobile examination centers. CRP was quantified from peripheral blood samples and analyzed as a continuous variable and as the prevalence of elevated CRP (≥ 10 mg/L). Some 12,949 people aged 18+ years who had periodontal examinations and an additional 1817 edentulous people aged 18+ years were included in the analysis. Dentate people with extensive periodontal disease (> 10% of sites with periodontal pockets 4+ mm) had an increase of approximately one-third in mean CRP and a doubling in prevalence of elevated CRP compared with periodontally healthy people. Raised CRP levels among people with extensive periodontal disease persisted in multivariate analyses (P < 0.01), with established risk factors for elevated CRP (diabetes, arthritis, emphysema, smoking, and anti-inflammatory medications) and sociodemographic factors controlled for. However, CRP levels were similarly raised in edentulous people. Furthermore, the established risk factors for elevated CRP modified relationships between oral status and CRP levels. Periodontal disease and edentulism were associated with systemic inflammatory response in the US population, most notably among people who had no established risk factors for elevated CRP.
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Cites
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
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Production of C-reactive protein and risk of coronary events in stable and unstable angina
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Periodontal Disease and Cardiovascular Disease
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Periodontal Diseases: Pathogenesis
Offenbacher, S. (1996) · Annals of Periodontology · doi:10.1902/annals.1996.1.1.821 · Cited by 1,028
Self-citationMendall, M. A., Patel, P., Ballam, L., Strachan, D., & Northfield, T. C. (1996) · BMJ · doi:10.1136/bmj.312.7038.1061 · Cited by 846
Saikku, P., Leinonen, M., Tenkanen, L., Linnanmäki, E., Ekman, M.-R., Manninen, V., Mänttäri, M., Frick, M. H., & Huttunen, J. K. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-4-273 · Cited by 786
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Epidemiologic research—1964–1967
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Cited by
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757
D’Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D., & Tonetti, M. S. (2004) · Journal of Dental Research · doi:10.1177/154405910408300214 · Cited by 746
Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases
Schenkein, H. A., & Loos, B. G. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12060 · Cited by 454
Mechanisms underlying the association between periodontitis and atherosclerotic disease
Schenkein, H. A., Papapanou, P. N., Genco, R., & Sanz, M. (2020) · Periodontology 2000 · doi:10.1111/prd.12304 · Cited by 440
Metadata
- Authors
- Slade, G. D., Offenbacher, S., Beck, J. D., Heiss, G., & Pankow, J. S.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2000-01
- Volume
- 79
- Issue
- 1
- Pages
- 49-57
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2135442806
- Cited by
- 458
- References
- 26
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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