The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antifungal Resistance of Candidal Biofilms Formed on Denture Acrylic in vitro
Abstract
Denture biofilms represent a protective reservoir for oral microbes. The study of the biology of Candida in these biofilms requires a reliable model. A reproducible model of C. albicans denture biofilm was developed and used to determine the susceptibility of two clinically relevant C. albicans isolates against 4 antifungals. C. albicans, growing as a biofilm, exhibited resistance to amphotericin B, nystatin, chlorhexidine, and fluconazole, with 50% reduction in metabolic activity (50% RMA) at concentrations of 8, 16, 128, and > 64 μg/mL, respectively. In contrast, planktonically cultured C. albicans were susceptible (50% RMA for the same antifungals was obtained at 0.25, 1.0, 4.0, and 0.5 μg/mL, respectively). In conclusion, results obtained by means of our biofilm model show that biofilm-associated C. albicans cells, compared with cells grown in planktonic form, are resistant to antifungals used to treat denture stomatitis.
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Citations
Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Biofilm formation by Candida species on the surface of catheter materials in vitro
Hawser, S. P., & Douglas, L. J. (1994) · Infection and Immunity · doi:10.1128/iai.62.3.915-921.1994 · Cited by 599
Self-citationEffect of Growth Rate on Resistance of Candida albicans Biofilms to Antifungal Agents
Baillie, G. S., & Douglas, L. J. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.8.1900 · Cited by 234
Self-citation
Cited by
Chandra, J., Kuhn, D. M., Mukherjee, P. K., Hoyer, L. L., McCormick, T., & Ghannoum, M. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5385-5394.2001 · Cited by 1,578
Self-citationCandida biofilms and their role in infection
Douglas, L. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00002-1 · Cited by 1,150
Self-citationEpidemiology and Etiology of Denture Stomatitis
Gendreau, L., & Loewy, Z. G. (2011) · Journal of Prosthodontics · doi:10.1111/j.1532-849x.2011.00698.x · Cited by 834
Ramage, G., Saville, S. P., Thomas, D. P., & López-Ribot, J. L. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.4.633-638.2005 · Cited by 678
Ramage, G., Rajendran, R., Sherry, L., & Williams, C. (2012) · International Journal of Microbiology · doi:10.1155/2012/528521 · Cited by 583
Metadata
- Authors
- Chandra, J., Mukherjee, P. K., Leidich, S. D., Faddoul, F. F., Hoyer, L. L., Douglas, L. J., & Ghannoum, M. A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2001-03
- Volume
- 80
- Issue
- 3
- Pages
- 903-908
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2156160379
- Cited by
- 597
- References
- 3
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chandra, J., Mukherjee, P. K., Leidich, S. D., Faddoul, F. F., Hoyer, L. L., Douglas, L. J., & Ghannoum, M. A. (2001). Antifungal Resistance of Candidal Biofilms Formed on Denture Acrylic in vitro. Journal of Dental Research. https://doi.org/10.1177/00220345010800031101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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