The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Oral Health and Adverse Pregnancy Outcomes – What’s Next?
Open accessAbstract
Studies on the link between periodontal disease and adverse pregnancy outcome have gone through several phases. The epidemiological studies predominantly support a positive association between these wide-affecting diseases. During the intervention phase, a few small-scale, single-center studies reported improvement of birth outcome following periodontal treatment, whereas the large-scale multi-center studies did not demonstrate efficacy. Many questions arise with regard to patient population, disease type, and therapy. In addressing these questions, it is crucial that one understands the mechanism underlying the link between these diseases. Two non-mutually exclusive hypotheses exist. In the first, periodontal disease is believed to affect the maternal and fetal immune responses systemically, leading to premature labor. Alternatively, evidence is accumulating that oral bacteria may translocate directly into the pregnant uterus, causing localized inflammation and adverse pregnancy outcome in the presence or absence of clinical periodontitis. The oral-uterine transmission is not limited to the well-recognized periodontal pathogens, but instead may also involve the commensal species. Future studies should investigate these mechanisms, to understand the host susceptibility to oral-uterine transmission. Only when a thorough understanding of the mechanism is achieved can meaningful intervention studies be designed utilizing effective therapies, targeting appropriate populations, and measuring relevant outcomes.
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“Pathogenic bacteria from the oral cavity found at various sites within the uterus are associated with adverse pregnancy outcomes, such as preterm delivery and preeclampsia.113, 114, 115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [114]
In the citing paper
“Studies investigating the placental microbiome to understand its role in preterm pregnancies have identified bacteria associated with periodontal disease, suggesting a relationship between the oral and placental microbiomes.113, 114, 115, 116”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [114]
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Intrauterine infection and preterm delivery
Goldenberg, R. L., Hauth, J. C., & Andrews, W. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422007 · Cited by 2,548
Periodontal infection as a possible risk factor for preterm low birth weight
Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., McKaig, R., & Beck, J. (1996) · Journal of Periodontology · doi:10.1902/jop.1996.67.10s.1103 · Cited by 1,455
Martin, J. A., Hamilton, B. E., Ventura, S. J., Menacker, F., & Park, M. M. (2002) · PubMed · Cited by 892
Martin, J. A., Hamilton, B. E., Ventura, S. J., Menacker, F., Park, M. M., & Sutton, P. D. (2002) · PubMed · Cited by 855
The Enigma of Spontaneous Preterm Birth
Muglia, L. J., & Katz, M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0904308 · Cited by 678
Treatment of Periodontal Disease and the Risk of Preterm Birth
Michalowicz, B. S., Hodges, J. S., DiAngelis, A. J., Lupo, V. R., Novak, M. J., Ferguson, J. E., II, Buchanan, W., Bofill, J. A., Papapanou, P. N., Mitchell, D. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062249 · Cited by 536
Periodontal infection and preterm birth
JEFFCOAT, M. K., GEURS, N. C., REDDY, M. S., CLIVER, S. P., GOLDENBERG, R. L., & HAUTH, J. C. (2001) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2001.0299 · Cited by 476
Han, Y. W., Redline, R. W., Mei, L., Yin, L., Hill, G. B., & McCormick, T. S. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2272-2279.2004 · Cited by 454
Self-citationHan, Y. W., Shi, W., Huang, G. T.-J., Kinder Haake, S., Park, N.-H., Kuramitsu, H., & Genco, R. J. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3140-3146.2000 · Cited by 435
Self-citationPeriodontal Disease and Preterm Birth: Results of a Pilot Intervention Study
Jeffcoat, M. K., Hauth, J. C., Geurs, N. C., Reddy, M. S., Cliver, S., Hodgkins, P. M., & Goldenberg, R. L. (2003) · Journal of Periodontology · doi:10.1902/jop.2003.74.8.1214 · Cited by 382
Research works printed but not linked: 1
- Martin JA, 2009, Natl Vital Stat Rep, 57, 1
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Sorted by citations
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494
Fusobacterium nucleatum: a commensal-turned pathogen
Han, Y. W. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.11.013 · Cited by 869
Self-citationThe oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Han, Y. W., & Wang, X. (2013) · Journal of Dental Research · doi:10.1177/0022034513487559 · Cited by 489
Self-citationCoppenhagen‐Glazer, S., Sol, A., Abed, J., Naor, R., Zhang, X., Han, Y. W., & Bachrach, G. (2015) · Infection and Immunity · doi:10.1128/iai.02838-14 · Cited by 249
Self-citation
Metadata
- Authors
- Han, Y. W.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Han, Y.W.
- ORCID
- Han, Y.W.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-11-01
- Volume
- 90
- Issue
- 3
- Pages
- 289-293
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC3144105
- OpenAlex
- W2064522421
- Cited by
- 133
- References
- 43
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 13 · 2013: 10 · 2012: 9
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R21 DE17165, K02DE016102, KO2DE16102, R01DE014924, R21DE017165, R01DE14924)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- periodontal disease, adverse pregnancy outcomes, preterm birth, periodontal treatment, oral bacteria, periodontitis, host susceptibility
- MeSH terms
- Clinical Trials as Topic, Female, Humans, Maternal-Fetal Exchange, Oral Health, Periodontitis, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Infectious Disease Transmission, Vertical, Premature Birth
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