Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum Adheres to and Invades Epithelial Cells

Han, Yiping W.; Shi, Wenyuan; Huang, George T.-J.; Kinder Haake, Susan; Park, No-Hee; Kuramitsu, Howard; Genco, Robert J.

doi:10.1128/iai.68.6.3140-3146.2000

Cited by 435Oral microbiology and periodontitis researchMicrobial infections and disease researchOral and gingival health research

Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum Adheres to and Invades Epithelial Cells

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Han, Yiping W., Shi, Wenyuan, Huang, George T.-J., Kinder Haake, Susan, Park, No-Hee, Kuramitsu, Howard, Genco, Robert J.·2000·Infection and Immunity

DOI 10.1128/iai.68.6.3140-3146.2000PMC PMC97547

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Abstract

Bacteria are causative agents of periodontal diseases. Interactions between oral bacteria and gingival epithelial cells are essential aspects of periodontal infections. Using an in vitro tissue culture model, a selected group of gram-negative anaerobic bacteria frequently associated with periodontal diseases, including Bacteroides forsythus , Campylobacter curvus , Eikenella corrodens , Fusobacterium nucleatum , Porphyromonas gingivalis , and Prevotella intermedia , were examined for their ability to adhere to and invade primary cultures of human gingival epithelial cells (HGEC). The effects of these bacteria on the production of interleukin-8 (IL-8), a proinflammatory chemokine, were also measured. These studies provided an initial demonstration that F. nucleatum adhered to and invaded HGEC and that this was accompanied by high levels of IL-8 secretion from the epithelial cells. The attachment and invasion characteristics of F. nucleatum were also tested using KB cells, an oral epithelial cell line. The invasion was verified by transmission electron microscopy and with metabolic inhibitors. Invasion appeared to occur via a “zipping” mechanism and required the involvement of actins, microtubules, signal transduction, protein synthesis, and energy metabolism of the epithelial cell, as well as protein synthesis by F. nucleatum . A spontaneous mutant, lam , of F. nucleatum , isolated as defective in autoagglutination, was unable to attach to or invade HGEC or KB cells, further indicating the requirement of bacterial components in these processes. Sugar inhibition assays indicated that lectin-like interactions were involved in the attachment of F. nucleatum to KB cells. Investigation of these new virulence phenotypes should improve our understanding of the role of F. nucleatum in periodontal infections.

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F. nucleatum's fadA adhesin allows it to adhere to and invade human epithelial cells, eliciting an inflammatory response and stimulating cell proliferation.
“F. nucleatum's fadA, a unique adhesin, allows it to adhere to and invade human epithelial cells, eliciting an inflammatory response97 and stimulating cell proliferation.98”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [97]

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Authors: Han, Y. W., Shi, W., Huang, G. T.-J., Kinder Haake, S., Park, N.-H., Kuramitsu, H., & Genco, R. J.
Affiliations: University at Buffalo, State University of New York (US)
Division of Oral Biology and Medicine2 and
University of California, Los Angeles (US)
ORCID: Han, Yiping W.
Shi, Wenyuan
Huang, George T.-J.
Genco, Robert J.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2000-06
Volume: 68
Issue: 6
Pages: 3140-3146
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.68.6.3140-3146.2000
PMC: PMC97547
OpenAlex: W2155044429
Cited by: 435
References: 38
Citations by year: 2026: 11 · 2025: 26 · 2024: 21 · 2023: 21 · 2022: 21 · 2021: 32 · 2020: 26 · 2019: 16 · 2018: 18 · 2017: 28 · 2016: 15 · 2015: 12 · 2014: 21 · 2013: 21 · 2012: 13
FWCI: 11.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01de008293-15)
National Institute of General Medical Sciences (GM54666, R01GM054666)
National Institute of Allergy and Infectious Diseases (AI 09268, F32AI009268)
National Institute of Dental and Craniofacial Research (DE08293)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
Keywords: Fusobacterium nucleatum, periodontal pathogens, gingival epithelial cells, bacterial adhesion, bacterial invasion, interleukin-8, periodontal disease, Gram-negative anaerobic bacteria, Tannerella forsythia, Campylobacter curvus, Eikenella corrodens, Porphyromonas gingivalis, Prevotella intermedia, bacterial virulence factors
MeSH terms: Bacterial Adhesion, Cell Line, Epithelial Cells, Gingiva, Humans, Protein Synthesis Inhibitors, Cytochalasin D, Nocodazole, Interleukin-8, Fusobacterium nucleatum, Staurosporine, Sodium Azide

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Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum Adheres to and Invades Epithelial Cells

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