Cited by 133Oral microbiology and periodontitis researchPreterm Birth and ChorioamnionitisGestational Diabetes Research and Management

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Oral Health and Adverse Pregnancy Outcomes – What’s Next?

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Han, Y.W.·2011·Journal of Dental Research

DOI 10.1177/0022034510381905PMC PMC3144105

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Abstract

Studies on the link between periodontal disease and adverse pregnancy outcome have gone through several phases. The epidemiological studies predominantly support a positive association between these wide-affecting diseases. During the intervention phase, a few small-scale, single-center studies reported improvement of birth outcome following periodontal treatment, whereas the large-scale multi-center studies did not demonstrate efficacy. Many questions arise with regard to patient population, disease type, and therapy. In addressing these questions, it is crucial that one understands the mechanism underlying the link between these diseases. Two non-mutually exclusive hypotheses exist. In the first, periodontal disease is believed to affect the maternal and fetal immune responses systemically, leading to premature labor. Alternatively, evidence is accumulating that oral bacteria may translocate directly into the pregnant uterus, causing localized inflammation and adverse pregnancy outcome in the presence or absence of clinical periodontitis. The oral-uterine transmission is not limited to the well-recognized periodontal pathogens, but instead may also involve the commensal species. Future studies should investigate these mechanisms, to understand the host susceptibility to oral-uterine transmission. Only when a thorough understanding of the mechanism is achieved can meaningful intervention studies be designed utilizing effective therapies, targeting appropriate populations, and measuring relevant outcomes.

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Authors: Han, Y. W.
Affiliations: Case Western Reserve University (US)
Corresponding author: Han, Y.W.
ORCID: Han, Y.W.
Venue: Journal of Dental Research
Publisher: SAGE Publications
Published: 2010-11-01
Volume: 90
Issue: 3
Pages: 289-293
ISSN: 0022-0345 (ISSN-L)
1544-0591
DOI: 10.1177/0022034510381905
PMC: PMC3144105
OpenAlex: W2064522421
Cited by: 133
References: 43
Citations by year: 2026: 4 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 13 · 2013: 10 · 2012: 9
FWCI: 1.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Dental Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (R21 DE17165, K02DE016102, KO2DE16102, R01DE014924, R21DE017165, R01DE14924)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: periodontal disease, adverse pregnancy outcomes, preterm birth, periodontal treatment, oral bacteria, periodontitis, host susceptibility
MeSH terms: Clinical Trials as Topic, Female, Humans, Maternal-Fetal Exchange, Oral Health, Periodontitis, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Infectious Disease Transmission, Vertical, Premature Birth

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