The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Porphyromonas gingivalis as a Potential Community Activist for Disease
Open accessAbstract
An extensive analysis of dental plaque samples over the years has led to the identification of “red” complex oral bacteria that have a strong association with each other and with disease. Consequently, these bacteria have been labeled ‘periopathogens’. Studies with one of these bacteria, Porphyromonas gingivalis, have revealed that it contains several different mechanisms which either impede or modulate periodontal protective mechanisms. In a mouse model of periodontitis, it has been shown that modulation of complement function by P. gingivalis facilitates a significant change in both the amount and composition of the normal oral microbiotia. This altered oral commensal microbiota is responsible for pathologic bone loss in the mouse. Thus, P. gingivalis creates a dysbiosis between the host and dental plaque, and this may represent one mechanism by which periodontitis can be initiated. We have therefore termed P. gingivalis a keystone pathogen.
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Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Challenges in the Quest for Keystones
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A note on trophic complexity and community stability.
Paine, R. T. (1969) · The American Naturalist · doi:10.1086/282586 · Cited by 1,796
Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.006 · Cited by 1,154
Self-citationLife Below the Gum Line: Pathogenic Mechanisms of Porphyromonas gingivalis
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The microbial challenge in periodontitis
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Self-citationHasturk, H., Kantarci, A., Goguet-Surmenian, E., Blackwood, A., Andry, C., Serhan, C. N., & Van Dyke, T. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.7021 · Cited by 461
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
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Self-citationEvidence of bacterial etiology: a historical perspective
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Local Chemokine Paralysis, a Novel Pathogenic Mechanism for Porphyromonas gingivalis
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Cited by
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Self-citationThe Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Dominy, S. S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau3333 · Cited by 1,966
Self-citationHajishengallis, G., & Lamont, R. J. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00663.x · Cited by 1,267
Self-citationImmunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150
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Metadata
- Authors
- Darveau, R. P., Hajishengallis, G., & Curtis, M. A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2012-07-06
- Volume
- 91
- Issue
- 9
- Pages
- 816-820
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2169732730
- Cited by
- 438
- References
- 23
- FWCI
- 33.39
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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