Heritability of Caries Scores, Trajectories, and Disease Subtypes
Open accessAbstract
Previous studies report that dental caries is partially heritable, but there is uncertainty in the magnitude of genetic effects and little understanding of how genetic factors might influence caries progression or caries subtypes. This study aimed to estimate the relative importance of genetic and environmental factors in the etiology of different caries outcomes using a twin-based design. Analysis included up to 41,678 twins in the Swedish Twin Register aged 7 to 97 y, and dental data were obtained from preexisting dental records. The outcome measures were 1) summary indices of caries experience, 2) parameters representing trajectory in caries progression derived from longitudinal modeling, and 3) caries scores in groups of biologically similar tooth surfaces derived from hierarchical clustering of tooth surfaces (termed caries clusters). Additive genetic factors explained between 49.1% and 62.7% of variation in caries scores and between 50.0% and 60.5% of variation in caries trajectories. Seven caries clusters were identified, which had estimates of heritability lying between 41.9% and 54.3%. Shared environmental factors were important for only some of these clusters and explained 16% of variation in fissure caries in molar teeth but little variation in other clusters of caries presentation. The genetic factors influencing these clusters were only partially overlapping, suggesting that different biological processes are important in different groups of tooth surfaces and that innate liability to some patterns of caries presentation may partially explain why groups of tooth surfaces form clusters within the mouth. These results provide 1) improved quantification of genetic factors in the etiology of caries and 2) new data about the role of genetics in terms of longitudinal changes in caries status and specific patterns of disease presentation, and they may help lay the foundations for personalized interventions in the future.
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Heritability of caries is nearly 50% among Swedish twins.
“Moreover, heritability of caries is nearly 50% among Swedish twins.140”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [140]
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- Authors
- Haworth, S., Esberg, A., Lif Holgerson, P., Kuja-Halkola, R., Timpson, N. J., Magnusson, P. K. E., Franks, P. W., & Johansson, I.
- Affiliations
- University of Bristol (GB)
- Umeå University (SE)
- Section of Pedodontics, Department of Odontology, Umeå University, Umeå, Sweden
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- Karolinska Institutet (SE)
- Harvard University (US)
- Corresponding author
- Haworth, S.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2020-01-06
- Volume
- 99
- Issue
- 3
- Pages
- 264-270
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC7036480
- OpenAlex
- W2994746417
- Cited by
- 38
- References
- 29
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 3
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Dental Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion, cc-by)
- Bristol Research (University of Bristol) (acceptedVersion, cc-by)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Stiftelsen Patentmedelsfonden fӧr Odontologisk Profylaxforskning (2017-019)
- Vetenskapsrådet (2011-03372, 2015-02597, 2017-00641)
- Topics
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- dental caries, heritability, genetic factors, fissure caries, molars, shared environmental factors, additive genetic effects, twin studies
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Cross-Sectional Studies, Dental Caries, Humans, Middle Aged, Molar, Tooth, Cluster Analysis, Young Adult
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