Cited by 201Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

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Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

Baskin, Denis G., Schwartz, Michael W., Seeley, Randy J., Woods, Stephen C., Porte, Daniel, Breininger, John F., Jonak, Zoë, Schaefer, Jonathan, Krouse, Michael, Burghardt, Charles, Campfield, L. Arthur, Burn, Paul, Kochan, Jarema P.·1999·Journal of Histochemistry & Cytochemistry

DOI 10.1177/002215549904700309

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Abstract

Reduced leptin (Ob protein) signaling is proposed to be a stimulus for the activation of neuropeptide Y (NPY) gene activity and increased expression of mRNA for the long form of the leptin receptor (Ob-Rb) in the hypothalamic arcuate nucleus. To determine if Ob-Rb protein is expressed in arcuate nucleus NPY neurons, we developed an affinity-purified polyclonal antibody against amino acids 956-1102 of human Ob-Rb. This antibody specifically recognizes the cytoplasmic tail of Ob-Rb and does not react with shorter leptin-receptor variants. Western immunoblots of Ob-Rb-transfected COS cells showed a single 150-kD band, and immunofluorescence revealed intense perinuclear staining in the cytoplasm. A 150-kD band was also present in Western immunoblots of hypothalamus. Immunocytochemical staining of brain slices revealed immunoreactive Ob-Rb protein concentrated in many neuronal cell bodies in the same regions of the forebrain that also express Ob-Rb mRNA. In the hypothalamus, Ob-Rb-positive cell bodies were abundant in the arcuate nucleus and ventromedial nucleus, with lesser numbers in the dorsomedial nucleus and paraventricular nucleus. Immunostaining was also detected in cell bodies of pyramidal cell neurons of the pyriform cortex and cerebral cortex, in neurons of the thalamus, and on the surface of ependymal cells lining the third ventricle. The choroid plexus, which expresses the short Ob-Ra form, was negative. Combined immunocytochemistry for Ob-Rb protein and fluorescence in situ hybridization for NPY mRNA identified arcuate nucleus neurons containing both NPY mRNA and Ob-Rb protein. The present finding of Ob-Rb protein in neurons that express NPY mRNA supports the hypothesis that arcuate nucleus NPY neurons are direct targets of leptin and play an important role in regulation of food intake and body weight.

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The Apparent Increase in Insulin Sensitivity of Leptin-Treated Rats Appears to be Due to a Decrease in Blood Glucose Concentrations in Response to Fasting
Gragg, M. (2007)
Unraveling Novel Leptin-Dependent Signaling Pathways in the Basomedial Hypothalamus.
Villanueva, E. C. (2010) · Deep Blue (University of Michigan)
Regulation of cAMP Level by PDE3B—Physiological Implications in Energy Balance and Insulin Secretion
Zhao, A. Z., & Holst, L. S. (2006) · CRC Press eBooks · doi:10.1201/9781420020847.ch17
Central Nervous System Nutrient-sensing and the Regulation of Energy and Glucose Homeostasis
Lam, K. L. C. (2010) · TSpace (University of Toronto)
Efeito da dieta hiperlipídica sobre a responsividade de neurônios kisspeptidérgicos à leptina
Venancio-Brochi, J. C. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2016.tde-06012016-164539
Peer Review #2 of "Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) (v0.2)"
(2019) · PeerJ · doi:10.7287/peerj.6848v0.2/reviews/2
Peer Review #1 of "Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) (v0.1)"
(2019) · PeerJ · doi:10.7287/peerj.6848v0.1/reviews/1
Peer Review #1 of "Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) (v0.2)"
(2019) · PeerJ · doi:10.7287/peerj.6848v0.2/reviews/1
Peer Review #2 of "Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) (v0.1)"
(2019) · PeerJ · doi:10.7287/peerj.6848v0.1/reviews/2
Influência da sensibilidade à leptina na maturação sexual de camundongos.
Bohlen, T. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2019.tde-31072019-072556
Leptin - a slimmer's dream that crashed?
Karlsson, C. (2000) · Europe PMC (PubMed Central)
Colocalization of mRNAs by Fluorescence in Situ Hybridization
Baskin, D. G., & Breininger, J. F. (1999) · Microscopy and Microanalysis · doi:10.1017/s1431927600015725
Self-citation
Investigating the basis of leptin resistance
Lin, S. (2003) · Research Online (University of Wollongong)
Brain Insulin and Obesity: From Man to C. elegans
Porte, D. (2004) · Handbook of behavioral neurobiology · doi:10.1007/0-306-48643-1_7
Self-citation
The Arcuate Nucleus
Beck, B. (2005) · Oxidative stress and disease · doi:10.1201/9781420028362.ch23
Peer Review #3 of "Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) (v0.2)"
(2019) · PeerJ · doi:10.7287/peerj.6848v0.2/reviews/3
Peer Review #3 of "Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) (v0.1)"
(2019) · PeerJ · doi:10.7287/peerj.6848v0.1/reviews/3
Sertraline’s deleterious effect on bone turnover in ovariectomized rats: The potential role of leptin, independent of estrogen.
Saad, S. S. T., & Medhet, M. (2023) · Ain Shams Journal of Forensic Medicine and Clinical Toxicology · doi:10.21608/ajfm.2023.279141
Participação da via da PI3K em neurônios SF1 do hipotálamo na homeostase energética
de Jesus, A. A. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2023.tde-08022024-155611
Implication des neurones exprimant NUCB2/nesfatine-1 dans la régulation de l'homéostasie énergétique
Bonnet, M. S. (2013) · theses.fr (ABES) · doi:10.70675/82840557z70b7z4214zbe5azca1e4f81d53a
Étude de la modulation par l’étonogestrel, l’érythropoïétine et la leptine de la réponse ventilatoire à l'hypercapnie. Détermination de cibles thérapeutiques potentielles pour le traitement des syndromes d’hypoventilation alvéolaire centrale
Perrin‐Terrin, A. (2018) · theses.fr (ABES) · doi:10.70675/e19e922bz4ab1z4df2z8e00z839db7c46630

Authors: Baskin, D. G., Schwartz, M. W., Seeley, R. J., Woods, S. C., Porte, D., Breininger, J. F., Jonak, Z., Schaefer, J., Krouse, M., Burghardt, C., Campfield, L. A., Burn, P., & Kochan, J. P.
Affiliations: University of Washington (US)
Department of Medicine, University of Washington, Seattle, Washington
VA Puget Sound Health Care System (US)
Department of Metabolic Diseases, Hoffmann-La Roche, Inc., Nutley, New Jersey
Corresponding author: Baskin, Denis G.
ORCID: Baskin, Denis G.
Schwartz, Michael W.
Seeley, Randy J.
Woods, Stephen C.
Venue: Journal of Histochemistry & Cytochemistry
Publisher: SAGE Publications
Published: 1999-03
Volume: 47
Issue: 3
Pages: 353-362
ISSN: 0022-1554 (ISSN-L)
1551-5044
DOI: 10.1177/002215549904700309
OpenAlex: W2123497298
Cited by: 200
References: 53
Citations by year: 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 10 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 11 · 2012: 9
FWCI: 7.05
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Histochemistry & Cytochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 12829, DK17844, DK-17047, R01DK012829, P30DK017047)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: leptin receptor, Ob-Rb, neuropeptide Y, arcuate nucleus, hypothalamus, neuronal expression, protein localization, cytoplasmic tail, food intake regulation, body weight regulation, leptin signaling, ventromedial hypothalamus, paraventricular nucleus, piriform cortex, ependymal cells, choroid plexus, Ob-Ra
MeSH terms: Animals, Antibodies, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Hypothalamus, Immunohistochemistry, Liver, Male, Neurons, Neuropeptide Y, Receptors, Cell Surface, RNA, Messenger, Blotting, Western, Rats, Wistar, Alternative Splicing, In Situ Hybridization, COS Cells, Rats, Receptors, Leptin

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Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

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