Induction of tubular peroxisomes by UV irradiation and reactive oxygen species in HepG2 cells
Open accessAbstract
Peroxisomes in the human hepatoblastoma cell line HepG2 exhibit a high degree of plasticity. Whereas in confluent cultures they appear as small (0.1-0.3 micrometer) spherical particles, they undergo dramatic changes, forming elongated tubules measuring up to 5 micrometer on separation of cells and cultivation at low density. We recently showed that several growth factors, including nerve growth factor (NGF), induce the formation of tubular peroxisomes and that this induction is sensitive to K 252b, a specific tyrosine kinase inhibitor, suggesting the involvement of this signal transduction pathway. Because tyrosine kinase is also involved in signal transduction via the reactive oxygen species (ROS), we have analyzed in this study the effects of UV irradiation, H(2)O(2), and oxygen on tubulation of peroxisomes. UVC irradiation induced a significant increase in formation of tubular peroxisomes (40-50% of cells) and this effect was dose-dependently inhibited by pretreatment with N-acetyl cysteine, confirming the involvement of ROS in the UV effect. Furthermore, H(2)O(2) also directly induced the tubulation of peroxisomes, although to a lesser extent. Finally, cultivation under hypoxic conditions (1.5% O(2)) drastically reduced the inducing effect of fetal calf serum on tubulation of peroxisomes, suggesting the involvement of oxygen-mediated signaling. Taken together, our observations indicate that ROS induce the tubulation of peroxisomes in HepG2 cells. Because peroxisomes harbor most of the enzymes for catabolism of ROS, the tubulation and expansion of the peroxisome compartment could have a cell rescue function against the destructive effects of ROS.
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Peroxisome proliferation can occur in response to cellular stress.
“Peroxisome proliferation can occur in response to cellular stress.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Schrader et al., 1999
Oxidants and ultraviolet light stimulate the elongation of peroxisomes in cultured hepatic cells.
“Oxidants and ultraviolet light stimulate the elongation of peroxisomes in cultured hepatic cells (Schrader et al., 1999).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Schrader et al., 1999
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- Authors
- Schrader, M., Wodopia, R., & Fahimi H., D.
- Affiliations
- Heidelberg University (DE)
- Institute for Anatomy and Cell Biology, Division II (Medical Cell Biology)
- ORCID
- Schrader, Michael
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1999-09
- Volume
- 47
- Issue
- 9
- Pages
- 1141-1148
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2007532475
- Cited by
- 51
- References
- 43
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Histochemistry & Cytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 601, SFB 352)
- Universität Hamburg
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- reactive oxygen species, UV irradiation, UV-C, hydrogen peroxide, hypoxia, oxygen signaling, N-acetylcysteine, tyrosine kinase, HepG2 cells, fetal bovine serum
- MeSH terms
- Acetylcysteine, Diglycerides, Dose-Response Relationship, Drug, Humans, Hydrogen Peroxide, Indoles, Maleimides, Microbodies, Oxygen, Partial Pressure, Protein Kinase C, Tumor Cells, Cultured, Ultraviolet Rays, Reactive Oxygen Species, Fluorescent Antibody Technique, Indirect
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