The Efficacy of Stimulant Drug Treatment for Hyperactivity: A Meta-Analysis
Abstract
This investigation reviews 135 studies examining the efficacy of stimulant drug treatment for hyperactivity. Meta-analysis, the analysis of analyses, is the methodological procedure used to integrate research findings. General findings indicate positive effects for drug intervention. In addition, subsets of data illustrating important behavioral, cognitive, and physiological outcomes were examined. Finally, variation among studies in terms of study features, subject characteristics, and design variables were investigated. Findings were compared and comrasted with previous reviews and showed that the extant literature provides a basis for concluding that stimulant drugs are an effective treatment for hyperactivity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a randomized, double-blind, placebo-controlled efficacy study of lisdexamfetamine, Childress et al. reported a significant improvement in emotional lability in LDEX-treated children with ADHD and high levels of emotional lability.
“More recently, in a randomized, double-blind, placebo-controlled efficacy study of lisdexamfetamine (LDEX), Childress et al [40] reported a significant improvement in emotional lability in the LDEX-treated children with ADHD and high levels of emotional lability.”
From Using Stimulants to Treat ADHD-Related Emotional Lability (2014) · cites this paper as [40]
Cites
Primary, Secondary, and Meta-Analysis of Research
GLASS, G. V. (1976) · Educational Researcher · doi:10.3102/0013189x005010003 · Cited by 4,890 · see citing works
The effects of stimulant medication on the growth of hyperkinetic children
Roche, A. F., Lipman, R. S., Overall, J. E., & Hung, W. (1979) · PEDIATRICS · doi:10.1542/peds.63.6.847 · Cited by 88 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lipsey, M. W., & Wilson, D. B. (1993) · American Psychologist · doi:10.1037/0003-066x.48.12.1181 · Cited by 2,033 · see citing works
DuPaul, G. J., Eckert, T. L., & Vilardo, B. (2012) · School Psychology Review · doi:10.1080/02796015.2012.12087496 · Cited by 439 · see citing works
Bupropion Hydrochloride in Attention Deficit Disorder with Hyperactivity
CONNERS, C. K., CASAT, C. D., GUALTIERI, C. T., WELLER, E., READER, M., REISS, A., WELLER, R. A., KHAYRALLAH, M., & ASCHER, J. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199610000-00018 · Cited by 342 · see citing works
Attention Deficit Disorder With Hyperactivity: A Specific Hypothesis of Reward Dysfunction
HAENLEIN, M., & CAUL, W. F. (1987) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198705000-00014 · Cited by 213 · see citing works
Hanwella, R., Senanayake, M., & de Silva, V. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-176 · Cited by 137 · see citing works
Forty years of methylphenidate treatment in Attention-Deficit/Hyperactivity Disorder
Conners, C. K. (2002) · Journal of Attention Disorders · doi:10.1177/070674370200601s04 · Cited by 135 · see citing works
Do Attention Deficits Influence IQ Assessment in Children and Adolescents with ADHD?
Jepsen, J. R. M., Fagerlund, B., & Mortensen, E. L. (2009) · Journal of Attention Disorders · doi:10.1177/1087054708322996 · Cited by 88 · see citing works
DUPAUL, G. J., & RAPPORT, M. D. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199301000-00027 · Cited by 87 · see citing works
Tucha, O., Prell, S., Mecklinger, L., Bormann-Kischkel, C., Kübber, S., Linder, M., Walitza, S., & Lange, K. W. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0318-2 · Cited by 89 · see citing works
Tamminga, H. G. H., Reneman, L., Huizenga, H. M., & Geurts, H. M. (2016) · Psychological Medicine · doi:10.1017/s0033291716000350 · Cited by 82 · see citing works
Using Stimulants to Treat ADHD-Related Emotional Lability
Posner, J., Kass, E., & Hulvershorn, L. (2014) · Current psychiatry reports · doi:10.1007/s11920-014-0478-4 · Cited by 66 · see citing works
Kambeitz, J., Romanos, M., & Ettinger, U. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.9 · Cited by 64 · see citing works
Silva, R. R., Muniz, R., Pestreich, L., Childress, A., Brams, M., Lopez, F. A., & Wang, J. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.239 · Cited by 44 · see citing works
- Authors
- Kavale, K.
- Affiliations
- University of California, Riverside (US)
- Corresponding author
- Kavale, Kenneth
- Venue
- Journal of Learning Disabilities
- Publisher
- SAGE Publications
- Published
- 1982-05
- Volume
- 15
- Issue
- 5
- Pages
- 280-289
- ISSN
- 0022-2194 (ISSN-L)
- 1538-4780
- OpenAlex
- W2147147287
- Cited by
- 152
- References
- 2
- Citations by year
- 2020: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Learning Disabilities (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- stimulants, hyperactivity, attention deficit hyperactivity disorder, drug efficacy, drug treatment outcomes, cognitive outcomes, physiological outcomes
- MeSH terms
- Achievement, Central Nervous System Stimulants, Attention, Attention Deficit Disorder with Hyperactivity, Blood Pressure, Body Height, Body Weight, Child, Child Behavior, Dextroamphetamine, Humans, Intelligence, Male, Memory, Methylphenidate, Motor Activity, Outcome and Process Assessment, Health Care, Research Design, Stimulation, Chemical
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
