Adolescent Participation in HIV Vaccine Trials: Cognitive Developmental Considerations
Abstract
Adolescents form an important target group for HIV vaccine trials for a number of reasons. These include the high HIVprevalence and incidence rates amongst adolescents, early sexual debut, multiple sexual partners, and other high-risk sexual behaviours. It has therefore been argued that the focus of HIV vaccination attempts should be on early adolescents younger than 15 years of age. Indeed, vaccination of adolescents prior to their sexual debut has been argued to have the potential to be one of the most effective ways to curb the HIV pandemic. While the biological and epidemiological arguments for vaccination of adolescents have been elucidated, this article offers some insight into the cognitive aspects of decision making in adolescence that may inform strategies vaccine trial sites might employ when dealing with adolescent participants. After a brief overview of the educational, biological, and relationship changes that occur during adolescence, this article explores some of the more pertinent cognitive changes that occur during adolescence. More specifically, this article explores the cognitive changes during adolescence that affect decision making, such as differences between younger and older adolescents in (a) choice, (b) comprehension, (c) creativity, (d) compromise, (e) consequentiality, (f) correctness, (g) credibility, (h) consistency, and (i) commitment. Research findings relating to the above changes are discussed, creating an argument for the exclusion of early adolescents in vaccine trials and the concomitant active engagement with middle adolescents.
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In middle adolescence (15 to 17) a strong development in metacognitive understanding emerges, including knowledge of one's own qualities, characteristics, and limitations with regard to decision-making.
“In middle adolescence (15 to 17) a strong development in metacognitive understanding emerges, including knowledge of one's own qualities, characteristics, and limitations with regard to decision-making [15].”
From Why is it hard to make progress in assessing children's decision-making competence? (2015) · cites this paper as [15]
Early adolescents (10 to 14) are more susceptible to peer influences than at any other age, which may hinder their ability to make thoughtful decisions.
“Various authors argue that early adolescents (10 to 14) are more susceptible to peer influences than at any other age [16], which may hinder their ability to make thoughtful decisions [15].”
From Why is it hard to make progress in assessing children's decision-making competence? (2015) · cites this paper as [15]
Cites
(1978) · Medical Entomology and Zoology · Cited by 53,488 · see citing works
The influence of parenting style on adolescent competence and substance use
Baumrind, D. (1991) · The Journal of Early Adolescence · doi:10.1177/0272431691111004 · Cited by 3,985 · see citing works
At the Threshold: The Developing Adolescent
Feldman, S. S., & Elliott, G. R. (1990) · Cited by 3,136 · see citing works
Eccles, J. S., Midgley, C., Wigfield, A., Buchanan, C. M., Reuman, D., Flanagan, C., & Mac Iver, D. (1993) · American Psychologist · doi:10.1037/0003-066x.48.2.90 · Cited by 2,616 · cited 1× · see citing works
“According to some researchers, the simultaneous occurrence of a number of changes makes adolescence a problematic period for many individuals (Eccles et al., 1993; Simmons & Blythe, 1987).”
BackgroundRalston, C. W. (1992) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-199204000-00011 · Cited by 2,244 · see citing works
Handbook of Adolescent Psychology
Plishka, P. C. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.11.1479 · Cited by 2,231 · see citing works
The Psychology of Intelligence.
Strauss, A., Piaget, J., Piercy, M., & Berlyne, D. E. (1951) · American Sociological Review · doi:10.2307/2088298 · Cited by 2,097 · see citing works
A Controlled Trial of a Human Papillomavirus Type 16 Vaccine
Koutsky, L. A., Ault, K. A., Wheeler, C. M., Brown, D. R., Barr, E., Alvarez, F. B., Chiacchierini, L. M., & Jansen, K. U. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020586 · Cited by 1,708 · see citing works
Harper, D. M., Franco, E. L., Wheeler, C. M., Ferris, D. G., Jenkins, D., Schuind, A., Zahaf, T., Innis, B. L., Naud, P., de Carvalho, N. S., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17398-4 · Cited by 1,639 · see citing works
The Vicissitudes of Autonomy in Early Adolescence
Steinberg, L., & Silverberg, S. B. (1986) · Child Development · doi:10.2307/1130361 · Cited by 1,523 · see citing works
The Vicissitudes of Autonomy in Early Adolescence
Steinberg, L. D., & Silverberg, S. B. (1986) · Child Development · doi:10.1111/j.1467-8624.1986.tb00250.x · Cited by 1,521 · see citing works
Decision Making--A Psychological Analysis of Conflict, Choice, and Commitment.
Elowitz, L., Janis, I. L., & Mann, L. (1978) · Military Affairs · doi:10.2307/1987412 · Cited by 1,449 · see citing works
Douvan, E. A. M., & Adelson, J. (1966) · Wiley eBooks · Cited by 1,235 · see citing works
Social support: theory, research, and intervention
(1989) · Choice Reviews Online · doi:10.5860/choice.26-4781 · Cited by 1,103 · see citing works
The Development of Children Ages 6 to 14
Eccles, J. S. (1999) · The Future of Children · doi:10.2307/1602703 · Cited by 1,046 · see citing works
South African National HIV Prevalence, HIV Incidence, Behaviour and Communication Survey, 2005
Simbayi, L. C., Zuma, K. K., Moyo, S., Marinda, E. T., Mabaso, M., Ramlagan, S., North, A., Mohlabane, N., Dietrich, C., & Naidoo, I. (2008) · Cited by 899 · see citing works
(1990) · Choice Reviews Online · doi:10.5860/choice.28-2416 · Cited by 714 · see citing works
The Competency of Children and Adolescents to Make Informed Treatment Decisions
Weithorn, L. A., & Campbell, S. B. (1982) · Child Development · doi:10.2307/1130087 · Cited by 688 · see citing works
Adolescent Relations with Mothers, Fathers, and Friends
Walters, J., Youniss, J., & Smollar, J. (1986) · Journal of Marriage and the Family · doi:10.2307/352416 · Cited by 660 · see citing works
The Growth of Logical Thinking
Smith, F. V., Inhelder, B., & Piaget, J. (1959) · British Journal of Educational Studies · doi:10.2307/3118518 · Cited by 596 · see citing works
Do parent-child relationships change during puberty?
Paikoff, R. L., & Jeanne Brooks-gunn, B. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.1.47 · Cited by 545 · see citing works
Unsafe sexual behaviour in South African youth
Eaton, L., Flisher, A. J., & Aarø, L. E. (2003) · Social Science & Medicine · doi:10.1016/s0277-9536(02)00017-5 · Cited by 536 · see citing works
Adolescent decision-making: the development of competence
Mann, L., Harmoni, R., & Power, C. (1989) · Journal of Adolescence · doi:10.1016/0140-1971(89)90077-8 · Cited by 355 · cited 7× · see citing works
“Young adolescents thus seem more likely to accept information without questioning the expertise or integrity of the source (Mann et al., 1989).”
BackgroundInfluentialHuman Papillomavirus Vaccine Acceptability Among Parents of 10- to 15-Year-Old Adolescents
Davis, K. L., Dickman, E. D., Ferris, D. G., & Dias, J. K. (2004) · Journal of Lower Genital Tract Disease · doi:10.1097/00128360-200407000-00005 · Cited by 348 · see citing works
THE PSYCHOLOGY OF EDUCATIONAL MEASUREMENT
Messick, S. (1984) · Journal of Educational Measurement · doi:10.1111/j.1745-3984.1984.tb01030.x · Cited by 243 · see citing works
Changes in functions of three relations during adolescence.
Hunter, F. T., & Youniss, J. (1982) · Developmental Psychology · doi:10.1037/0012-1649.18.6.806 · Cited by 235 · see citing works
Parental perspectives on vaccinating children against sexually transmitted infections
Mays, R. M., Sturm, L. A., & Zimet, G. D. (2003) · Social Science & Medicine · doi:10.1016/s0277-9536(03)00335-6 · Cited by 218 · see citing works
Parental Beliefs and Decision Making About Child and Adolescent Immunization
Sturm, L. A., Mays, R. M., & Zimet, G. D. (2005) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200512000-00009 · Cited by 205 · see citing works
Understanding Children's Development
Smith, A. B. (1982) · Cited by 195 · see citing works
Buga, G. A. B., Amoko, D. H., & Ncayiyana, D. J. (1996) · PubMed · Cited by 192 · see citing works
How Adolescents Approach Decisions: Changes over Grades Seven to Twelve and Policy Implications
Lewis, C. (1981) · Child Development · doi:10.2307/1129172 · Cited by 173 · see citing works
Chase-Lansdale, P. L., Wakschlag, L. S., & Brooks‐Gunn, J. (1995) · Journal of Adolescence · doi:10.1006/jado.1995.1037 · Cited by 166 · see citing works
Self-Determination for Persons with Disabilities: Choice, Risk, and Dignity
Schloss, P. J., Alper, S., & Jayne, D. (1993) · Exceptional Children · doi:10.1177/001440299406000303 · Cited by 96 · see citing works
HOPKINS, J. R. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-355580-9.50009-1 · Cited by 95 · see citing works
Cognitive Development Today: Piaget and His Critics
Sutherland, P. (1992) · SAGE Publications Ltd eBooks · doi:10.4135/9781446280591 · Cited by 94 · see citing works
Adolescents and their families: paths of ego development
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2394 · Cited by 94 · see citing works
A metacognitive analysis of decision making in adolescence
Ormond, C., Luszcz, M. A., Mann, L., & Beswick, G. (1991) · Journal of Adolescence · doi:10.1016/0140-1971(91)90021-i · Cited by 85 · see citing works
Jaspan, H. B., Lawn, S. D., Safrit, J. T., & Bekker, L. (2006) · AIDS · doi:10.1097/01.aids.0000210602.40267.60 · Cited by 81 · see citing works
Self-citationAbramovitch, R., Freedman, J. L., Henry, K., & Brunschot, M. V. (1995) · Ethics & Behavior · doi:10.1207/s15327019eb0501_3 · Cited by 75 · see citing works
Conformity development as a function of self-blame.
Costanzo, P. R. (1970) · Journal of Personality and Social Psychology · doi:10.1037/h0028983 · Cited by 75 · see citing works
Peer referencing in adolescent decision making as a function of perceived parenting style.
Bednar, D. E., & Fisher, T. D. (2003) · PubMed · Cited by 73 · see citing works
Decision Making and Risk Behaviors of Cancer-Surviving Adolescents and Their Peers
Hollen, P. J., & Hobbie, W. L. (1996) · Journal of Pediatric Oncology Nursing · doi:10.1177/104345429601300304 · Cited by 68 · see citing works
Minors' ability to identify risks and benefits of therapy.
Kaser‐Boyd, N., Adelman, H. S., & Taylor, L. K. (1985) · Professional Psychology Research and Practice · doi:10.1037/0735-7028.16.3.411 · Cited by 67 · see citing works
Australian psychology : review of research
Feather, N. T. (1985) · Cited by 57 · see citing works
Challenges to Conducting HIV Preventative Vaccine Trials With Adolescents
Poffenberger, C., Gray, G., Rybczyk, G. K., & Wright, P. F. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200406010-00010 · Cited by 53 · see citing works
Young, J. W., & Ferguson, L. R. (1979) · Journal of Youth and Adolescence · doi:10.1007/bf02087623 · Cited by 47 · see citing works
Children's Competence to Participate in Healthcare Decisions
Beidler, S. M., & Dickey, S. B. (2001) · JONA s Healthcare Law Ethics and Regulation · doi:10.1097/00128488-200109000-00004 · Cited by 39 · see citing works
Delius, P., & Walker, L. (2002) · African Studies · doi:10.1080/00020180220140046 · Cited by 37 · see citing works
Minors' attitudes and competence toward participation in psychoeducational decisions.
Taylor, L. K., Adelman, H. S., & Kaser‐Boyd, N. (1985) · Professional Psychology Research and Practice · doi:10.1037/0735-7028.16.2.226 · Cited by 35 · see citing works
Perspectives of children regarding their participation in psychoeducational decisions.
Taylor, L. K., Adelman, H. S., & Kaser‐Boyd, N. (1983) · Professional Psychology Research and Practice · doi:10.1037/0735-7028.14.6.882 · Cited by 34 · see citing works
Adolescents' attitudes about HIV immunization
Zimet, G. D. (1999) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/24.1.67 · Cited by 31 · see citing works
Consent Issues in Medico‐Legal Procedures: How Competent Are Children to Make Their Own Decisions?
Fundudis, T. (2003) · Child and Adolescent Mental Health · doi:10.1111/1475-3588.00040 · Cited by 30 · see citing works
Adolescent social development: Dynamic functional interaction
Canever, N. (1983) · Behaviour Research and Therapy · doi:10.1016/0005-7967(83)90106-7 · Cited by 21 · see citing works
Clements, C. J., Karim, Q. A., Chang, M.-L., Nkowane, B. M., & Esparza, J. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.002 · Cited by 19 · see citing works
Adolescent vaccination in the developing world: time for serious consideration?
Stevens, W., & Walker, D. G. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.05.001 · Cited by 17 · see citing works
What ‘s Sex Got to Do with It: The Development of Sexual Identities during Adolescence
Brooks‐Gunn, J., & Graber, J. A. (1999) · doi:10.1093/oso/9780195127300.003.0007 · Cited by 12 · see citing works
The Effects of Androstenediol and Dehydroepiandrosterone on the Immune Response to BCG at Puberty
Kutlu, N. O., Akıncı, A., Sönmezgöz, E., Temel, İ., & Evliyaoğlu, E. (2003) · Journal of Tropical Pediatrics · doi:10.1093/tropej/49.3.181 · Cited by 11 · see citing works
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Why is it hard to make progress in assessing children's decision-making competence?
Hein, I. M., Troost, P. W., Broersma, A., de Vries, M. C., Daams, J. G., & Lindauer, R. J. L. (2015) · BMC Medical Ethics · doi:10.1186/1472-6939-16-1 · Cited by 191 · see citing works
“Various authors argue that early adolescents (10 to 14) are more susceptible to peer influences than at any other age [16], which may hinder their ability to make thoughtful decisions [15].”
BackgroundDay, S., Kapogiannis, B. G., Shah, S. K., Wilson, E. C., Ruel, T., Conserve, D. F., Strode, A. E., Donenberg, G. R., Kohler, P. K., Slack, C. M., et al. (2020) · The Lancet HIV · doi:10.1016/s2352-3018(20)30269-1 · Cited by 38 · see citing works
Behavioral Considerations for Engaging Youth in HIV Clinical Research
Hosek, S., & Zimet, G. D. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181e15c22 · Cited by 28 · see citing works
Lally, M., Goldsworthy, R. C., Sarr, M., Kahn, J. A., Brown, L. K., Peralta, L., & Zimet, G. D. (2014) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2014.01.006 · Cited by 28 · see citing works
Adolescent decision making about participation in a hypothetical HIV vaccine trial
Alexander, A. B., Ott, M. A., Lally, M., Sniecinski, K., Baker, A., & Zimet, G. D. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.01.049 · Cited by 26 · see citing works
Social and behavioral science in HIV vaccine trials: a gap assessment of the literature
Lau, C., Stansbury, J. P., Gust, D. A., & Kafaar, Z. (2009) · Expert Review of Vaccines · doi:10.1586/14760584.8.2.179 · Cited by 9 · see citing works
Self-citationWilliamson, V., Coetzee, B., Kagee, A., & Tomlinson, M. (2016) · Future Virology · doi:10.2217/fvl-2016-0090 · Cited by 4 · see citing works
Self-citationKafaar, Z. (2015) · SUNScholar (Stellenbosch University) · Cited by 1 · see citing works
Self-citationTobón, O. E. A., Pérez, G. A. C., Quintero, S., Montoya, C. M., Mesa, S. A. M., & Bustamante, A. R. (2013) · Universitas Psychologica · doi:10.11144/javeriana.upsy12-3.rpap
- Authors
- Kafaar, Z., Swartz, L., Kagee, A., Lesch, A., & Jaspan, H.
- Affiliations
- Stellenbosch University (ZA)
- Corresponding author
- Kafaar, Zuhayr
- Venue
- South African Journal of Psychology
- Publisher
- SAGE Publications
- Published
- 2007-08
- Volume
- 37
- Issue
- 3
- Pages
- 576-594
- ISSN
- 0081-2463 (ISSN-L)
- OpenAlex
- W2124244384
- Cited by
- 9
- References
- 56
- Citations by year
- 2020: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- South African Journal of Psychology (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Health Professions › General Health Professions › Adolescent Sexual and Reproductive Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Ethics and Legal Issues in Pediatric Healthcare
- Keywords
- cognitive development, adolescent decision-making, HIV prevention, early adolescents, middle adolescence, vaccine trial participation, comprehension, creativity, compromise, consequentiality, credibility, commitment
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