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Cited by 150

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Clinical Pharmacokinetics of Phosphodiesterase‐5 Inhibitors for Erectile Dysfunction

Gupta, Manish, Kovar, Andreas, Meibohm, Bernd·2005·The Journal of Clinical Pharmacology
DOI 10.1177/0091270005276847
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Abstract

Differences in the clinical pharmacology of the 3 currently available oral phosphodiesterase‐5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, are largely determined by their clinical pharmacokinetics as well as their PDE inhibitory activity profile. This review comparatively discusses the major characteristics of the pharmacokinetic profile of all 3 PDE5 inhibitors, including bioavailability and rate of absorption, Biopharmaceutical Classification System categorization, elimination mechanisms, and metabolic profile including active metabolites, as well as the drug‐drug interaction potential and modification of pharmacokinetic properties under selected physiologic and pathophysiologic conditions. The review is aimed at providing comparative clinical pharmacology data to allow for scientifically rational, evidence‐based prescribing and dosing decisions regarding the clinical use of these medications for the treatment of erectile dysfunction.

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Cited by

Metadata

Authors
Gupta, M., Kovar, A., & Meibohm, B.
Venue
The Journal of Clinical Pharmacology
Publisher
Wiley
Published
2005-09
Volume
45
Issue
9
Pages
987-1003
ISSN
  • 0091-2700
  • 1552-4604
DOI
10.1177/0091270005276847
Cited by
150
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2756 d)

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