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Multiple Drug Resistance in Cancer Revisited: The Cancer Stem Cell Hypothesis
Open accessAbstract
The failure to eradicate cancer may be as fundamental as a misidentification of the target. Current therapies succeed at eliminating bulky disease but often miss a tumor reservoir that is the source of disease recurrence and metastasis. Recent advances in the understanding of tissue development and repair cause us to revisit the process of drug resistance as it applies to oncogenesis and tumor heterogeneity. The cancer stem cell hypothesis states that the cancer‐initiating cell is a transformed tissue stem cell, which retains the essential property of self‐protection through the activity of multiple drug resistance (MDR) transporters. This resting constitutively drug‐resistant cell remains at low frequency among a heterogeneous tumor mass. In the context of this hypothesis, the authors review the discovery of MDR transporters in cancer and normal stem cells and the failure of MDR reversal agents to increase the therapeutic index of substrate antineoplastic agents.
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Cited by
Pro-senescence therapy for cancer treatment
Nardella, C., Clohessy, J. G., Alimonti, A., & Pandolfi, P. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3057 · Cited by 437
Dai, C.-L., Tiwari, A. K., Wu, C.-P., Su, X.-D., Wang, S.-R., Liu, D.-G., Ashby, C. R., Huang, Y., Robey, R. W., Liang, Y.-J., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0499 · Cited by 386
Role of integrated cancer nanomedicine in overcoming drug resistance
Iyer, A. K., Singh, A., Ganta, S., & Amiji, M. M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.012 · Cited by 343
Cancer Targeting and Drug Delivery Using Carbon-Based Quantum Dots and Nanotubes
Pardo, J., Peng, Z., & Leblanc, R. (2018) · Molecules · doi:10.3390/molecules23020378 · Cited by 226
Mechanisms of Disease: Cancer stem cells--targeting the evil twin
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Metadata
- Authors
- Donnenberg, V. S., & Donnenberg, A. D.
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2005-08
- Volume
- 45
- Issue
- 8
- Pages
- 872-877
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2012495753
- Cited by
- 457
- References
- 1
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Donnenberg, V. S., & Donnenberg, A. D. (2005). Multiple Drug Resistance in Cancer Revisited: The Cancer Stem Cell Hypothesis. The Journal of Clinical Pharmacology. https://doi.org/10.1177/0091270005276905
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
