Role of integrated cancer nanomedicine in overcoming drug resistance
Abstract
Cancer remains a major killer of mankind. Failure of conventional chemotherapy has resulted in recurrence and development of virulent multi drug resistant (MDR) phenotypes adding to the complexity and diversity of this deadly disease. Apart from displaying classical physiological abnormalities and aberrant blood flow behavior, MDR cancers exhibit several distinctive features such as higher apoptotic threshold, aerobic glycolysis, regions of hypoxia, and elevated activity of drug-efflux transporters. MDR transporters play a pivotal role in protecting the cancer stem cells (CSCs) from chemotherapy. It is speculated that CSCs are instrumental in reviving tumors after the chemo and radiotherapy. In this regard, multifunctional nanoparticles that can integrate various key components such as drugs, genes, imaging agents and targeting ligands using unique delivery platforms would be more efficient in treating MDR cancers. This review presents some of the important principles involved in development of MDR and novel methods of treating cancers using multifunctional-targeted nanoparticles. Illustrative examples of nanoparticles engineered for drug/gene combination delivery and stimuli responsive nanoparticle systems for cancer therapy are also discussed.
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Due to the enhanced permeability and retention effect, selective accumulation in solid tumors can be used to target hypoxic tumors more effectively.
“Due to the enhanced permeability and retention effect (EPR effect), 174 selective accumulation in solid tumors can be used to target hypoxic tumors more effectively.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [175]
Cites
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works
Bonnet, D., & Dick, J. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,417 · see citing works
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
Epithelial–mesenchymal transitions in tumour progression
Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,632 · see citing works
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536 · see citing works
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282 · see citing works
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177 · see citing works
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587 · see citing works
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552 · see citing works
What Is the Evidence That Tumors Are Angiogenesis Dependent?
Folkman, J. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.1.4 · Cited by 4,509 · see citing works
Identification and expansion of human colon-cancer-initiating cells
Ricci‐Vitiani, L., Lombardi, D. G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., & Maria, R. D. (2006) · Nature · doi:10.1038/nature05384 · Cited by 4,001 · see citing works
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637 · see citing works
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Visvader, J., & Lindeman, G. (2008) · Nature Reviews. Cancer · doi:10.1038/nrc2499 · Cited by 3,562 · see citing works
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Panyam, J., & Labhasetwar, V. D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00228-4 · Cited by 3,365 · see citing works
Impact of Nanotechnology on Drug Delivery
Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,364 · see citing works
Identification of Pancreatic Cancer Stem Cells
Li, C., Heidt, D. G., Dalerba, P. D., Burant, C., Zhang, L., Adsay, V. N., Wicha, M. S., Clarke, M. F., & Simeone, D. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2030 · Cited by 3,344 · see citing works
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115 · see citing works
Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J. M., Wang, A. Z., Langer, R., & Farokhzad, O. C. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,685 · see citing works
Tumour evolution inferred by single-cell sequencing
Navin, N., Kendall, J., Troge, J., Andrews, P., Rodgers, L., McIndoo, J., Cook, K., Stepansky, A., Levy, D., Esposito, D., et al. (2011) · Nature · doi:10.1038/nature09807 · Cited by 2,598 · see citing works
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
Singh, A., & Settleman, J. (2010) · Oncogene · doi:10.1038/onc.2010.215 · Cited by 2,545 · see citing works
Self-citationHaase, M., & Schäfer, H. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005159 · Cited by 2,503 · see citing works
Maeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495 · see citing works
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
Gupta, P. B., Önder, T. T., Jiang, G., Tao, K. X., Kuperwasser, C., Weinberg, R. A., & Lander, E. S. (2009) · Cell · doi:10.1016/j.cell.2009.06.034 · Cited by 2,393 · see citing works
PEGylation, successful approach to drug delivery
Veronese, F. M., & Pasut, G. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03575-0 · Cited by 2,344 · see citing works
Prince, M. E., Sivanandan, R., Kaczorowski, A., Wolf, G. T., Kaplan, M. J., Dalerba, P. D., Weissman, I. L., Clarke, M. F., & Ailles, L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610117104 · Cited by 2,165 · see citing works
Chemotherapy and the war on cancer
Chabner, B. A., & Roberts, T. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1529 · Cited by 2,152 · see citing works
Drug Resistance and the Solid Tumor Microenvironment
Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · see citing works
Light-induced shape-memory polymers
Lendlein, A., Jiang, H., Jünger, O., & Langer, R. (2005) · Nature · doi:10.1038/nature03496 · Cited by 2,006 · see citing works
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993 · see citing works
Exploiting the enhanced permeability and retention effect for tumor targeting
Iyer, A. K., Khaled, G., Fang, J., & Maeda, H. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.07.005 · Cited by 1,846 · see citing works
Self-citationImmunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823 · see citing works
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Vermeulen, L., De Sousa E Melo, F., van der Heijden, M., Cameron, K., de Jong, J. H., Borovski, T., Tuynman, J. B., Todaro, M., Merz, C., Rodermond, H., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2048 · Cited by 1,804 · see citing works
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,706 · see citing works
Saito, G., Swanson, J. A., & Lee, K.-D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00179-5 · Cited by 1,407 · see citing works
Dendrimers and dendritic polymers in drug delivery
Gillies, E. R., & Fréchet, J. M. J. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03276-3 · Cited by 1,361 · see citing works
The function of sterols in membranes
DEMEL, R. A., & Kruyff, B. D. (1976) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(76)90008-3 · Cited by 1,347 · see citing works
Imaging and drug delivery using theranostic nanoparticles
Janib, S. M., Moses, A. S., & MacKay, J. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.08.004 · Cited by 1,249 · see citing works
Lutz, J. (2008) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.22706 · Cited by 1,246 · see citing works
Hedgehog Signaling and Bmi-1 Regulate Self-renewal of Normal and Malignant Human Mammary Stem Cells
Liu, S., Dontu, G., Mantle, I. D., Patel, S. H., Ahn, N.-S., Jackson, K. W., Suri, P., & Wicha, M. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0054 · Cited by 1,241 · see citing works
Du, J., Du, X., Mao, C., & Wang, J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207150n · Cited by 1,176 · see citing works
Thermoresponsive Polymers for Biomedical Applications
Ward, M. A., & Georgiou, T. K. (2011) · Polymers · doi:10.3390/polym3031215 · Cited by 1,165 · see citing works
(1996) · PubMed · Cited by 1,141 · see citing works
Stimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, F., Zhong, Z., & Feijén, J. (2009) · Biomacromolecules · doi:10.1021/bm801127d · Cited by 1,122 · see citing works
Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs
Sugahara, K. N., Teesalu, T., Karmali, P. P., Kotamraju, V. R., Agemy, L., Greenwald, D. R., & Ruoslahti, E. I. (2010) · Science · doi:10.1126/science.1183057 · Cited by 1,080 · see citing works
Combinatorial drug therapy for cancer in the post-genomic era
Al-Lazikani, B., Banerji, U., & Workman, P. (2012) · Nature Biotechnology · doi:10.1038/nbt.2284 · Cited by 1,070 · see citing works
Microbubbles in ultrasound-triggered drug and gene delivery
Hernot, S., & Klibanov, A. L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.005 · Cited by 990 · see citing works
Cancer stem cells: mirage or reality?
Gupta, P. B., Chaffer, C. L., & Weinberg, R. A. (2009) · Nature Medicine · doi:10.1038/nm0909-1010 · Cited by 982 · see citing works
The Promise and Perils of Wnt Signaling Through β-Catenin
Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970 · see citing works
Hope, K. J., Jin, L., & Dick, J. E. (2004) · Nature Immunology · doi:10.1038/ni1080 · Cited by 968 · see citing works
Solid lipid nanoparticles (SLN) for controlled drug delivery – Drug release and release mechanism
Mühlen, A. Z., Schwarz, C., & Mehnert, W. (1998) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(97)00150-1 · Cited by 945 · see citing works
Maeda, H., Sawa, T., & Konno, T. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00309-1 · Cited by 926 · see citing works
Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers
Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., & Chilkoti, A. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj070 · Cited by 911 · see citing works
RNAi therapeutics: Principles, prospects and challenges
Aagaard, L., & Rossi, J. J. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.005 · Cited by 895 · see citing works
Histone Deacetylase Inhibitors in Cancer Therapy
Lane, A. A., & Chabner, B. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.1291 · Cited by 880 · see citing works
Lutz, J., & Hoth, A. (2005) · Macromolecules · doi:10.1021/ma0517042 · Cited by 860 · see citing works
(2002) · PubMed · Cited by 840 · see citing works
Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
Sinha, R., Gloria, K., Nie, S., & Shin, D. M. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0141 · Cited by 802 · see citing works
Nanoparticle-based combination therapy toward overcoming drug resistance in cancer
Hu, C. J., & Zhang, L. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.01.008 · Cited by 688 · see citing works
Feldmann, G., Dhara, S., Fendrich, V., Bedja, D., Beaty, R. M., Mullendore, M. E., Karikari, C. A., Alvarez, H., Iacobuzio–Donahue, C. A., Jimeno, A., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3281 · Cited by 685 · see citing works
Anthrazykline in der Krebstherapie
Hortobágyi, G. N. (1997) · Drugs · doi:10.2165/00003495-199700544-00003 · Cited by 679 · see citing works
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
Grünert, S., Jechlinger, M., & Beug, H. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1175 · Cited by 677 · see citing works
Chen, A. M., Zhang, M., Wei, D., Stueber, D., Taratula, O., Minko, T., & He, H. (2009) · Small · doi:10.1002/smll.200900621 · Cited by 671 · see citing works
Wang, Y., Gao, S., Ye, W., Yoon, H. S., & Yang, Y. Y. (2006) · Nature Materials · doi:10.1038/nmat1737 · Cited by 658 · see citing works
siRNA vs. shRNA: Similarities and differences
Rao, D. D., Vorhies, J. S., Senzer, N. N., & Nemunaitis, J. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.04.004 · Cited by 658 · see citing works
The therapeutic promise of the cancer stem cell concept.
Frank, N., Schatton, T., & Frank, M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41004 · Cited by 648 · see citing works
Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma
Bar, E. E., Chaudhry, A., Lin, A. Y., Fan, X., Schreck, K. C., Matsui, W. H., Piccirillo, S. G. M., Vescovi, A. L., DiMeco, F., Olivi, A., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0166 · Cited by 607 · see citing works
Meng, H., Xue, M., Xia, T., Zhao, Y., Tamanoi, F., Stoddart, J. F., Zink, J. I., & Nel, A. E. (2010) · Journal of the American Chemical Society · doi:10.1021/ja104501a · Cited by 596 · see citing works
Dassie, J. P., Liu, X., Thomas, G. S., Whitaker, R. M., Thiel, K. W., Stockdale, K. R., Meyerholz, D. K., McCaffrey, A. P., McNamara, J. O., & Giangrande, P. H. (2009) · Nature Biotechnology · doi:10.1038/nbt.1560 · Cited by 591 · see citing works
Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds
Merisko-Liversidge, E. M., & Liversidge, G. G. (2008) · Toxicologic Pathology · doi:10.1177/0192623307310946 · Cited by 581 · see citing works
Passive and Active Drug Targeting: Drug Delivery to Tumors as an Example
Torchilin, V. P. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00477-3_1 · Cited by 578 · see citing works
Meng, H., Mai, W. X., Zhang, H., Xue, M., Xia, T., Lin, S., Wang, X., Zhao, Y., Ji, Z., Zink, J. I., et al. (2013) · ACS Nano · doi:10.1021/nn3044066 · Cited by 576 · see citing works
Mani, S. A., Yang, J., Brooks, M. W., Schwaninger, G., Zhou, A. Y., Miura, N., Kutok, J. L., Hartwell, K. A., Richardson, A. L., & Weinberg, R. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703900104 · Cited by 576 · see citing works
Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting
Li, S., & Huang, L. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.03.016 · Cited by 562 · see citing works
Understanding cancer stem cell heterogeneity and plasticity
Tang, D. G. (2012) · Cell Research · doi:10.1038/cr.2012.13 · Cited by 559 · see citing works
Drug Release from Electric-Field-Responsive Nanoparticles
Ge, J., Neofytou, E. A., Cahill, T. J., Beygui, R. E., & Zare, R. N. (2011) · ACS Nano · doi:10.1021/nn203430m · Cited by 534 · see citing works
Light‐sensitive Intelligent Drug Delivery Systems<sup>†</sup>
Alvarez‐Lorenzo, C., Bromberg, L., & Concheiro, A. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00530.x · Cited by 519 · see citing works
Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance
Shapira, A., Livney, Y. D., Broxterman, H. J., & Assaraf, Y. G. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.01.003 · Cited by 509 · see citing works
Kong, G., Anyarambhatla, G., Petros, W. P., Braun, R. D., Colvin, O. M., Needham, D., & Dewhirst, M. W. (2000) · PubMed · Cited by 505 · see citing works
Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal
Tsuruo, T., Naito, M., Tomida, A., Fujita, N., Mashima, T., Sakamoto, H., & Haga, N. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01345.x · Cited by 502 · see citing works
Wadhwa, R., Lagenaur, C. F., & Cui, X. T. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.10.027 · Cited by 498 · see citing works
Dromi, S. A., Frenkel, V., Luk, A., Traughber, B. J., Angstadt, M., Bur, M., Poff, J. A., Xie, J., Libutti, S. K., Li, K. C., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2443 · Cited by 494 · see citing works
Qing, Y., Wang, S., Fan, P., Wang, L., Di, Y., Lin, K., & Xiao, F. (2005) · Chemistry of Materials · doi:10.1021/cm051198v · Cited by 490 · see citing works
Ganta, S., & Amiji, M. M. (2009) · Molecular Pharmaceutics · doi:10.1021/mp800240j · Cited by 489 · see citing works
Self-citationCancer Stem Cells and Drug Resistance: The Potential of Nanomedicine
Vinogradov, S. V., & Wei, X. (2012) · Nanomedicine · doi:10.2217/nnm.12.22 · Cited by 474 · see citing works
pH‐Responsive Supramolecular Nanovalves Based on Cucurbit[6]uril Pseudorotaxanes
Angelos, S., Yang, Y., Patel, K., Stoddart, J. F., & Zink, J. I. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200705211 · Cited by 468 · see citing works
Manzoor, A. A., Lindner, L. H., Landon, C. D., Park, J. Y., Simnick, A. J., Dreher, M. R., Das, S. K., Hanna, G., Park, W., Chilkoti, A., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1683 · Cited by 461 · see citing works
A New Design for Light-Breakable Polymer Micelles
Jiang, J., Tong, X., & Zhao, Y. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0521019 · Cited by 460 · see citing works
Multiple Drug Resistance in Cancer Revisited: The Cancer Stem Cell Hypothesis
Donnenberg, V. S., & Donnenberg, A. D. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005276905 · Cited by 457 · see citing works
Yan, B., Boyer, J., Branda, N. R., & Zhao, Y. (2011) · Journal of the American Chemical Society · doi:10.1021/ja209793b · Cited by 455 · see citing works
Park, C., Oh, K., Lee, S. C., & Kim, C. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200603404 · Cited by 453 · see citing works
Targeting Notch to Target Cancer Stem Cells
Pannuti, A., Foreman, K. E., Rizzo, P., Osipo, C., Golde, T. E., Osborne, B. A., & Miele, L. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2823 · Cited by 452 · see citing works
Aptamer mediated siRNA delivery
Chu, T. C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl388 · Cited by 447 · see citing works
Electrochemically controlled drug delivery based on intrinsically conducting polymers
Svirskis, D. M., Travaš‐Sejdić, J., Rodgers, A., & Garg, S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.03.023 · Cited by 440 · see citing works
Arunachalam, B., Phan, U., Geuze, H. J., & Cresswell, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.745 · Cited by 438 · see citing works
Yin, X., Hoffman, A. S., & Stayton, P. S. (2006) · Biomacromolecules · doi:10.1021/bm0507812 · Cited by 417 · see citing works
Multi-functional nanocarriers to overcome tumor drug resistance
Milane, L. S., van Vlerken, L. E., Yadav, S. K., & Amiji, M. M. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.04.003 · Cited by 407 · see citing works
Self-citationRecent advances in shell cross-linked micelles
Read, E. S., & Armes, S. P. (2007) · Chemical Communications · doi:10.1039/b701217a · Cited by 404 · see citing works
Crack Healing in Polymeric Materials via Photochemical [2+2] Cycloaddition
Chung, C., Roh, Y.-S., Cho, S., & Kim, J. (2004) · Chemistry of Materials · doi:10.1021/cm049394+ · Cited by 402 · see citing works
Pharmacological Strategies for Overcoming Multidrug Resistance
Nobili, S., Landini, I., Giglioni, B., & Mini, E. (2006) · Current Drug Targets · doi:10.2174/138945006777709593 · Cited by 395 · see citing works
Toward Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles
Jiang, J., Tong, X., Morris, D., & Zhao, Y. (2006) · Macromolecules · doi:10.1021/ma060142z · Cited by 394 · see citing works
He, Q., Gao, Y., Zhang, L., Zhang, Z., Gao, F., Ji, X., Li, Y., & Shi, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.066 · Cited by 393 · see citing works
Folkins, C., Man, S., Xu, P., Shaked, Y., Hicklin, D. J., & Kerbel, R. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4238 · Cited by 384 · see citing works
Co-Delivery of siRNA and An Anticancer Drug for Treatment of Multidrug-Resistant Cancer
Saad, M., Garbuzenko, O. B., & Minko, T. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.761 · Cited by 368 · see citing works
Ganesh, S., Iyer, A. K., Morrissey, D. V., & Amiji, M. M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.077 · Cited by 361 · see citing works
Self-citationStem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer
Steg, A. D., Bevis, K. S., Katre, A. A., Ziebarth, A., Dobbin, Z. C., Alvarez, R. D., Zhang, K., Conner, M. G., & Landen, C. N. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2188 · Cited by 359 · see citing works
Prospects of RNA interference therapy for cancer
Pai, S. I., Lin, Y.-Y., Macaes, B., Meneshian, A., Hung, C.-F., & Wu, T. ‐. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302694 · Cited by 351 · see citing works
Polymer Micelles Stabilization on Demand through Reversible Photo-Cross-Linking
Jiang, J., Qi, B., Lepage, M., & Zhao, Y. (2007) · Macromolecules · doi:10.1021/ma062493j · Cited by 340 · see citing works
Delbaldo, C., Michiels, S., Syz, N., Soria, J., Chevalier, T. L., & Pignon, J. (2004) · JAMA · doi:10.1001/jama.292.4.470 · Cited by 338 · see citing works
Chemotherapy-induced resistance by ATP-binding cassette transporter genes
Gillet, J. A., Efferth, T., & Remacle, J. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.05.002 · Cited by 336 · see citing works
Sethuraman, V. A., & Bae, Y. H. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.008 · Cited by 336 · see citing works
Notch and cancer: a double-edged sword
Koch, U., & Radtke, F. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7164-1 · Cited by 335 · see citing works
Allikmets, R. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.10.1649 · Cited by 334 · see citing works
Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound
Gao, Z., Fain, H. D., & Rapoport, N. Y. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.021 · Cited by 328 · see citing works
Electrically Controlled Drug Delivery from Biotin‐Doped Conductive Polypyrrole
George, P. M., LaVan, D. A., Burdick, J. A., Chen, C. ‐., Liang, E., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501242 · Cited by 320 · see citing works
Magnetic field triggered drug release from polymersomes for cancer therapeutics
Oliveira, H., Pérez-Andrés, E., Thévenot, J., Sandre, O., Berra, E., & Lecommandoux, S. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.01.013 · Cited by 310 · see citing works
Patil, Y. B., Swaminathan, S. K., Sadhukha, T., Ma, L., & Panyam, J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.048 · Cited by 304 · see citing works
Greish, K. F., Fang, J. Q., Inutsuka, T., Nagamitsu, A., & Maeda, H. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342130-00002 · Cited by 277 · see citing works
Yoo, J., Doshi, N., & Mitragotri, S. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.05.004 · Cited by 273 · see citing works
Brazel, C. S. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9773-2 · Cited by 264 · see citing works
Wu, C., Calcagno, A. M., & Ambudkar, S. V. (2008) · Current Molecular Pharmacology · doi:10.2174/1874467210801020093 · Cited by 257 · see citing works
Frontiers in cancer nanomedicine: directing mass transport through biological barriers
Mauro Ferrari, B. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.12.007 · Cited by 256 · see citing works
Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives
Saunders, N. A., Simpson, F., Thompson, E. W., Hill, M. M. C., Endo‐Munoz, L., Leggatt, G. R., Minchin, R. F., & Guminski, A. D. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201101131 · Cited by 249 · see citing works
Development of Novel Combination Therapies
Woodcock, J., Griffin, J. P., & Behrman, R. E. (2011) · New England Journal of Medicine · doi:10.1056/nejmp1101548 · Cited by 248 · see citing works
Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-8343-0 · Cited by 246 · see citing works
Self-citationPolymer-Caged Lipsomes: A pH-Responsive Delivery System with High Stability
Lee, S., Chen, H., Dettmer, C. M., O’Halloran, T. V., & Nguyen, S. T. (2007) · Journal of the American Chemical Society · doi:10.1021/ja070748i · Cited by 245 · see citing works
Gene expression control by temperature with thermo-responsive polymeric gene carriers
Kurisawa, M., Yokoyama, M., & Okano, T. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00297-2 · Cited by 237 · see citing works
Active targeting with particulate drug carriers in tumor therapy: fundamentals and recent progress
Marcucci, F., & Lefoulon, F. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02988-x · Cited by 235 · see citing works
Meewes, M., Rička, J., Silva, M. D., Nyffenegger, R. M., & Binkert, T. (1991) · Macromolecules · doi:10.1021/ma00021a014 · Cited by 235 · see citing works
Boddapati, S. V., D’Souza, G. G. M., Erdoğan, S., Torchilin, V. P., & Weissig, V. (2008) · Nano Letters · doi:10.1021/nl801908y · Cited by 234 · see citing works
Is tumor growth sustained by rare cancer stem cells or dominant clones?
Adams, J., & Strasser, A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6334 · Cited by 233 · see citing works
Factors affecting acoustically triggered release of drugs from polymeric micelles
Husseini, G. A., Myrup, G. D., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00278-9 · Cited by 228 · see citing works
Kheirolomoom, A., Dayton, P. A., Lum, A. F. H., Little, E. L., Paoli, E. E., Zheng, H., & Ferrara, K. W. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.015 · Cited by 225 · see citing works
Side Population Cells Isolated from Mesenchymal Neoplasms Have Tumor Initiating Potential
Wu, C., Wei, Q., Utomo, V., Nadesan, P., Whetstone, H., Kandel, R. A., Wunder, J. S., & Alman, B. A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0999 · Cited by 221 · see citing works
Kommareddy, S., & Amiji, M. M. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050146t · Cited by 220 · see citing works
Self-citationTriggered content release from optimized stealth thermosensitive liposomes using mild hyperthermia
Li, L., ten Hagen, T. L. M., Schipper, D., Wijnberg, T. M., van Rhoon, G. C., Eggermont, A. M. M., Lindner, L. H., & Koning, G. A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.006 · Cited by 215 · see citing works
van Vlerken, L. E., Duan, Z., Seiden, M. V., & Amiji, M. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1648 · Cited by 214 · see citing works
Self-citationMarin, A., Sun, H., Husseini, G. A., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00262-6 · Cited by 213 · see citing works
Looking ahead in cancer stem cell research
Dick, J. E. (2009) · Nature Biotechnology · doi:10.1038/nbt0109-44 · Cited by 212 · see citing works
Anyarambhatla, G., & Needham, D. (1999) · Journal of Liposome Research · doi:10.3109/08982109909035549 · Cited by 199 · see citing works
Thermoresponsive core–shell magnetic nanoparticles for combined modalities of cancer therapy
Purushotham, S., Chang, J. P.-E., Rumpel, H., Kee, I. H. C., Ng, R. T. H., Chow, P. K. H., Tan, C., & Ramanujan, R. V. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/30/305101 · Cited by 198 · see citing works
Witta, S. E., Jotte, R. M., Konduri, K., Neubauer, M., Spira, A. I., Ruxer, R. L., Varella‐Garcia, M., Bunn, P. A., & Hirsch, F. R. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.9411 · Cited by 197 · see citing works
Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia
Li, L., ten Hagen, T. L. M., Bolkestein, M., Gasselhuber, A., Yatvin, J., van Rhoon, G. C., Eggermont, A. M. M., Haemmerich, D., & Koning, G. A. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.01.026 · Cited by 196 · see citing works
Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Molecular Pharmaceutics · doi:10.1021/mp0500420 · Cited by 193 · see citing works
Self-citationEfficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology
Chen, S., Ding, J.-H., Bekeredjian, R., Yang, B.-Z., Shohet, R. V., Johnston, S. A., Hohmeier, H. E., Newgard, C. B., & Grayburn, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602921103 · Cited by 189 · see citing works
Kaneshiro, T. L., & Lu, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.026 · Cited by 186 · see citing works
Huang, S. K., Stauffer, P. R., Hong, K., Guo, J., Phillips, T. L., Huang, A., & Papahadjopoulos, D. (1994) · PubMed · Cited by 183 · see citing works
Fast Photodegradable Block Copolymer Micelles for Burst Release
Han, D., Tong, X., & Zhao, Y. (2011) · Macromolecules · doi:10.1021/ma102778d · Cited by 183 · see citing works
Di Maio, M., Chiodini, P., Georgoulias, V., Hatzidaki, D., Takeda, K., Wachters, F. M., Gebbia, V., Smit, E. F., Morabito, A., Gallo, C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.5844 · Cited by 181 · see citing works
Arginine functionalized peptide dendrimers as potential gene delivery vehicles
Luo, K., Li, C., Li, L., She, W., Wang, G., & Gu, Z. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.030 · Cited by 179 · see citing works
Werner, M. E., Karve, S., Sukumar, R., Cummings, N. D., Copp, J. A., Chen, R. C., Zhang, T., & Wang, A. Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.07.067 · Cited by 176 · see citing works
Wu, J. H., Lu, Y., Lee, A., Pan, X., Yang, X., Zhao, X. B., & Lee, R. J. (2007) · PubMed · Cited by 172 · see citing works
Kono, K., Ozawa, T., Yoshida, T., Ozaki, F., Ishizaka, Y., Maruyama, K., Kojima, C., Harada, A., & Aoshima, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.045 · Cited by 168 · see citing works
Susa, M., Iyer, A. K., Ryu, K., Hornicek, F. J., Mankin, H. J., Amiji, M. M., & Duan, Z. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-399 · Cited by 162 · see citing works
Self-citationMilane, L. S., Duan, Z., & Amiji, M. M. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1002653 · Cited by 161 · see citing works
Self-citationAntibodies targeting cancer stem cells: A new paradigm in immunotherapy?
Deonarain, M. P., Kousparou, C. A., & Epenetos, A. A. (2009) · mAbs · doi:10.4161/mabs.1.1.7347 · Cited by 160 · see citing works
Bhavsar, M. D., & Amiji, M. M. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.03.006 · Cited by 159 · see citing works
Self-citationKühnle, M., Egger, M. E., Müller, C., Mahringer, A., Bernhardt, G., Fricker, G., König, B., & Buschauer, A. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm8013822 · Cited by 158 · see citing works
Susa, M., Iyer, A. K., Ryu, K., Choy, E., Hornicek, F. J., Mankin, H. J., Milane, L. S., Amiji, M. M., & Duan, Z. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010764 · Cited by 157 · see citing works
Self-citationMulti-functional nanocarriers for targeted delivery of drugs and genes.
Jabr-Milane, L., van Vlerken, L. V., Devalapally, H., Shenoy, D., Komareddy, S., Bhavsar, M., & Amiji, M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.04.016 · Cited by 156 · see citing works
Self-citationDevalapally, H., Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0287-5 · Cited by 155 · see citing works
Self-citationSumaru, K., Ohi, K., Takagi, T., Kanamori, T., & Shinbo, T. (2006) · Langmuir · doi:10.1021/la052899+ · Cited by 150 · see citing works
Controlled Pulsatile Drug Release from a Ferrogel by a High-Frequency Magnetic Field
Hu, S., Liu, T., Liu, D., & Chen, S. (2007) · Macromolecules · doi:10.1021/ma0707584 · Cited by 146 · see citing works
Kommareddy, S., & Amiji, M. M. (2007) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2006.11.005 · Cited by 144 · see citing works
Self-citationChen, H., Li, H., Li, J., Zhu, Z. G., Yin, S., Hao, X., Yao, M., Zheng, S.-S., & Gu, J. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn223 · Cited by 142 · see citing works
Loh, X. J., Zhang, Z., Wu, Y., Lee, T. S., & Li, J. (2008) · Macromolecules · doi:10.1021/ma8019865 · Cited by 141 · see citing works
Kommareddy, S., & Amiji, M. M. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20813 · Cited by 139 · see citing works
Self-citationObata, Y., Tajima, S., & Takeoka, S. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.023 · Cited by 138 · see citing works
Ganesh, S., Iyer, A. K., Weiler, J., Morrissey, D. V., & Amiji, M. M. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.29 · Cited by 134 · see citing works
Self-citationIntegrin-mediated targeting of drug delivery to irradiated tumor blood vessels
Hallahan, D. E., Geng, L., Qu, S., Scarfone, C., Giorgio, T. D., Donnelly, E. F., Gao, X., & Clanton, J. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00238-6 · Cited by 134 · see citing works
Magnetic-nanoparticle-modified paclitaxel for targeted therapy for prostate cancer
Hua, M., Yang, H., Chuang, C., Tsai, R., Chen, W.-J., Chuang, K., Chang, Y., Chuang, H., & Pang, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.061 · Cited by 130 · see citing works
Expression of Multidrug Resistance Genes in Normal and Cancer Stem Cells
Shervington, A. A., & Lu, C. (2008) · Cancer Investigation · doi:10.1080/07357900801904140 · Cited by 130 · see citing works
The tumor microenvironment controls drug sensitivity
Östman, A. (2012) · Nature Medicine · doi:10.1038/nm.2938 · Cited by 129 · see citing works
Rapoport, N. Y., Marin, A., Luo, Y., Prestwich, G. D., & Muniruzzaman, M. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10006 · Cited by 128 · see citing works
Hu, S., Chen, S., Liu, D., & Hsiao, C.-S. (2008) · Advanced Materials · doi:10.1002/adma.200800193 · Cited by 127 · see citing works
Milane, L. S., Ganesh, S., Shah, S., Duan, Z., & Amiji, M. M. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.03.032 · Cited by 127 · see citing works
Self-citationYavlovich, A., Singh, A., Blumenthal, R. P., & Puri, A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.07.030 · Cited by 127 · see citing works
Self-citationArrieta, O. G., la Rosa, C. H. G.-D., Aréchaga-Ocampo, E., Villanueva-Rodríguez, G., Cerón-Lizárraga, T., Martínez-Barrera, L. M., Vázquez-Manríquez, M. E., Ríos-Trejo, M. Á., Álvarez-Avitia, M. Á., Hernández‐Pedro, N., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.6452 · Cited by 125 · see citing works
Ganta, S., Devalapally, H., & Amiji, M. (2010) · Journal of Pharmacy and Science · doi:10.1002/jps.22157 · Cited by 125 · see citing works
Self-citationABC transporters and their role in nucleoside and nucleotide drug resistance
Fukuda, Y., & Schuetz, J. D. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.042 · Cited by 123 · see citing works
Modular Synthesis of Biodegradable Diblock Copolymers for Designing Functional Polymersomes
Katz, J. S., Zhong, S., Ricart, B. G., Pochan, D. J., Hammer, D. A., & Burdick, J. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910606y · Cited by 123 · see citing works
Kono, K., Nakashima, S., Kokuryo, D., Aoki, I., Shimomoto, H., Aoshima, S., Maruyama, K., Yuba, E., Kojima, C., Harada, A., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.050 · Cited by 123 · see citing works
Luo, K., Li, C., Wang, G., Nie, Y., He, B., Wu, Y., & Gu, Z. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.006 · Cited by 121 · see citing works
Ultrasound-enhanced tumor targeting of polymeric micellar drug carriers
Gao, Z., Fain, H. D., & Rapoport, N. (2004) · Molecular Pharmaceutics · doi:10.1021/mp049958h · Cited by 121 · see citing works
Fischer, M. M., Yen, W.-C., Kapoun, A. M., Wang, M., O’Young, G., Lewicki, J. A., Gurney, A. L., & Hoey, T. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2817 · Cited by 120 · see citing works
Milane, L. S., Duan, Z., & Amiji, M. M. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-3 · Cited by 118 · see citing works
Self-citationCombinatorial-Designed Multifunctional Polymeric Nanosystems for Tumor-Targeted Therapeutic Delivery
Abeylath, S. C., Ganta, S., Iyer, A. K., & Amiji, M. M. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000106 · Cited by 117 · see citing works
Self-citationRichardson, S. C. W., Ferruti, P., & Duncan, R. (1999) · Journal of drug targeting · doi:10.3109/10611869908996846 · Cited by 116 · see citing works
Acoustic activation of drug delivery from polymeric micelles: effect of pulsed ultrasound
Marin, A., Muniruzzaman, M., & Rapoport, N. Y. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00216-4 · Cited by 112 · see citing works
Vihola, H., Laukkanen, A., Tenhu, H. J., & Hirvonen, J. J. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21348 · Cited by 111 · see citing works
Devalapally, H., Duan, Z., Seiden, M. V., & Amiji, M. M. (2007) · International Journal of Cancer · doi:10.1002/ijc.22886 · Cited by 110 · see citing works
Self-citationWang, Y., Wang, B., Qiao, W., & Yin, T. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22189 · Cited by 110 · see citing works
Santos, J. L., Pandita, D., Rodrigues, J., Pêgo, A. P., Granja, P. L., Balian, G., & Tomás, H. (2010) · Molecular Pharmaceutics · doi:10.1021/mp9002877 · Cited by 108 · see citing works
Polymeric Carriers for Gene Delivery: Chitosan and Poly(amidoamine) Dendrimers
Xu, Q., Wang, C., & Pack, D. W. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791920469 · Cited by 106 · see citing works
Deep local hyperthermia for cancer therapy: external electromagnetic and ultrasound techniques.
Cheung, A. Y., & Neyzari, A. (1984) · PubMed · Cited by 105 · see citing works
Hacker, M. C., Klouda, L., Ma, B. B., Kretlow, J. D., & Mikos, A. G. (2008) · Biomacromolecules · doi:10.1021/bm8000414 · Cited by 104 · see citing works
Therapeutic Significance of Elevated Tissue Transglutaminase Expression in Pancreatic Cancer
Verma, A. K., Guha, S., Diagaradjane, P., Kunnumakkara, A. B., Sanguino, A. M., Lopez‐Berestein, G., Sood, A. K., Aggarwal, B. B., Krishnan, S., Gelovani, J. G., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4529 · Cited by 101 · see citing works
Yin, Q., Shen, J., Chen, L., Zhang, Z., Gu, W., & Li, Y. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.039 · Cited by 100 · see citing works
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Cancer nanomedicine: from targeted delivery to combination therapy
Xu, X., Ho, W., Zhang, X., Bertrand, N., & Farokhzad, O. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.01.001 · Cited by 693 · see citing works
Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine
Mattheolabakis, G., Milane, L., Singh, A., & Amiji, M. M. (2015) · Journal of Drug Targeting · doi:10.3109/1061186x.2015.1052072 · Cited by 597 · see citing works
Self-citationNanoparticles in Drug Delivery: From History to Therapeutic Applications
Afzal, O., Altamimi, A. S. A., Nadeem, M. S., Alzarea, S. I., Almalki, W. H., Tariq, A., Mubeen, B., Murtaza, B. N., Iftikhar, S., Riaz, N., et al. (2022) · Nanomaterials · doi:10.3390/nano12244494 · Cited by 468 · see citing works
Cancer stem cell (CSC) resistance drivers
Najafi, M., Mortezaee, K., & Majidpoor, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116781 · Cited by 473 · see citing works
Biological agents for synthesis of nanoparticles and their applications
Pandit, C., Roy, A., Ghotekar, S. K., Khusro, A., Islam, M. N., Emran, T. B., Lam, S. E., Khandaker, M. U., & Bradley, D. A. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.101869 · Cited by 454 · see citing works
Recent advances in dendrimer-based nanovectors for tumor-targeted drug and gene delivery
Kesharwani, P., & Iyer, A. K. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.12.012 · Cited by 382 · see citing works
Self-citationCarrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy
Zhang, R., Xing, R., Jiao, T., Ma, K., Chen, C., Ma, G., & Yan, X. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b02416 · Cited by 317 · see citing works
Aggressive Man‐Made Red Blood Cells for Hypoxia‐Resistant Photodynamic Therapy
Liu, W., Liu, T., Zou, M., Yu, W., Li, C., He, Z., Zhang, M., Liu, M., Li, Z., Feng, J. X., et al. (2018) · Advanced Materials · doi:10.1002/adma.201802006 · Cited by 310 · see citing works
Tian, G., Zhang, X., Gu, Z., & Zhao, Y. (2015) · Advanced Materials · doi:10.1002/adma.201503280 · Cited by 279 · see citing works
Emerging role of tumor cell plasticity in modifying therapeutic response
Qin, S., Jiang, J., Lü, Y., Nice, E. C., Huang, C., Zhang, J., & He, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00313-5 · Cited by 274 · see citing works
Review of Natural Compounds for Potential Skin Cancer Treatment
Chinembiri, T. N., Plessis, D., Gerber, M., Hamman, J. H., & du Plessis, J. (2014) · Molecules · doi:10.3390/molecules190811679 · Cited by 273 · see citing works
Du, X. C., Li, X., Xiong, L., Zhang, X., Kleitz, F., & Qiao, S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.019 · Cited by 262 · see citing works
Recent advances in drug delivery systems for targeting cancer stem cells
Duan, H., Liu, Y., Gao, Z., & Huang, W. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.09.016 · Cited by 257 · see citing works
Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery
Vaughan, H. J., Green, J. J., & Tzeng, S. Y. (2019) · Advanced Materials · doi:10.1002/adma.201901081 · Cited by 257 · see citing works
Chen, J., Jin, R., Zhao, J., Liu, J., Ying, H., Yan, H., Zhou, S., Liang, Y., Huang, D., Liang, X. H., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.019 · Cited by 252 · see citing works
Advances of medical nanorobots for future cancer treatments
Kong, X., Gao, P., Wang, J., Fang, Y., & Hwang, K. C. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01463-z · Cited by 253 · see citing works
Kanapathipillai, M., Brock, A., & Ingber, D. E. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.005 · Cited by 234 · see citing works
Pan, W., Tan, Y., Meng, W., Huang, N.-H., Zhao, Y.-B., Yu, Z., Huang, Z., Zhang, W., Sun, B., & Chen, J.-X. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121449 · Cited by 233 · see citing works
Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
Zhou, L., Wang, H., & Li, Y. (2018) · Theranostics · doi:10.7150/thno.22679 · Cited by 232 · see citing works
Durfee, P. N., Lin, Y., Dunphy, D. R., Muñiz, A. J., Butler, K. S., Humphrey, K. R., Lokke, A. J., Agola, J. O., Chou, S. S., Chen, I., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b02819 · Cited by 219 · see citing works
Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment
Yang, G., Liu, J., Wu, Y., Feng, L., & Liu, Z. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.04.004 · Cited by 207 · see citing works
Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
Wang, J., Seebacher, N. A., Shi, H., Kan, Q., & Duan, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.19187 · Cited by 209 · see citing works
Zhang, H., Fei, J., Yan, X., Wang, A., & Li, J. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201403119 · Cited by 194 · see citing works
Poly(β‐Amino Esters): Synthesis, Formulations, and Their Biomedical Applications
Liu, Y., Li, Y., Keskin, D., & Shi, L. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801359 · Cited by 192 · see citing works
Nanoformulations for combination or cascade anticancer therapy
Miao, L., Guo, S., Lin, C. M., Liu, Q., & Huang, L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.003 · Cited by 178 · see citing works
Castillo, R. R., Colilla, M., & Vallet‐Regí, M. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1211637 · Cited by 177 · see citing works
Shen, W. H., Liu, W., Yang, H., Zhang, P., Xiao, C., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.011 · Cited by 175 · see citing works
Sun, R., Liu, Y., Li, S.-Y., Shen, S., Du, X.-J., Xu, C.-F., Cao, Z.-T., Bao, Y., Zhu, Y.-H., Li, Y.-P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.018 · Cited by 172 · see citing works
Photonanomedicine: a convergence of photodynamic therapy and nanotechnology
Obaid, G., Broekgaarden, M., Bulin, A., Huang, H., Kuriakose, J., Liu, J., & Hasan, T. G. (2016) · Nanoscale · doi:10.1039/c5nr08691d · Cited by 168 · see citing works
Zhao, X., Chen, Q., Li, Y.-S., Tang, H., Liu, W., & Yang, X. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.003 · Cited by 167 · see citing works
Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy
Jia, R., Teng, L., Gao, L., Su, T., Fu, L., Qiu, Z., & Bi, Y. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s293427 · Cited by 160 · see citing works
Liu, Y., & Feng, N. (2015) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2015.04.006 · Cited by 156 · see citing works
Sau, S., Alsaab, H. O., Bhise, K., Alzhrani, R. M., Nabil, G., & Iyer, A. K. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.028 · Cited by 152 · see citing works
Self-citationInorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics
Lin, G., Mi, P., Chu, C., Zhang, J., & Liu, G. (2016) · Advanced Science · doi:10.1002/advs.201600134 · Cited by 149 · see citing works
Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance
Najafi, M., Farhood, B., Mortezaee, K., Kharazinejad, E., Majidpoor, J., & Ahadi, R. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-03080-1 · Cited by 146 · see citing works
Szczepanowicz, K., Bazylińska, U., Pietkiewicz, J., Szyk‐Warszyńska, L., Wilk, K. A., & Warszyński, P. (2014) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2014.10.005 · Cited by 145 · see citing works
Millard, M., Yakavets, I., Zorin, V. P., Kulmukhamedova, A., Marchal, S., & Bezdetnaya, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146927 · Cited by 141 · see citing works
Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy
Liu, W., Dong, A., Wang, B., & Zhang, H. (2021) · Advanced Science · doi:10.1002/advs.202003033 · Cited by 138 · see citing works
Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies
Feltrin, F. D. S., Agner, T., Sayer, C., & Lona, L. M. F. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102582 · Cited by 142 · see citing works
Combination antitumor therapy with targeted dual-nanomedicines
Dai, W., Wang, X., Song, G., Liu, T., He, B., Zhang, H., Wang, X., & Zhang, Q. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.03.001 · Cited by 139 · see citing works
CircRNAs: biogenesis, functions, and role in drug-resistant Tumours
Ma, S., Kong, S., Wang, F., & Ju, S. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01231-4 · Cited by 137 · see citing works
The Therapeutic Benefit of Bacterial Membrane Vesicles
Bitto, N. J., & Kaparakis‐Liaskos, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061287 · Cited by 133 · see citing works
Rahikkala, A., Pereira, S. A. P., Figueiredo, P., Passos, M. L. C., Araújo, A. R. T. S., Saraiva, M. L. M. F. S., & Santos, H. A. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800020 · Cited by 134 · see citing works
The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance
Chen, K., Zhang, C., Ling, S., Wei, R., Wang, J., & Xu, X. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04116-6 · Cited by 133 · see citing works
Kovács, D., Igaz, N., Keskeny, C., Bélteky, P., Tóth, T., Gáspár, R., Madarász, D., Rázga, Z., Kónya, Z., Boros, I., et al. (2016) · Scientific Reports · doi:10.1038/srep27902 · Cited by 124 · see citing works
Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
Targeted hydroxyethyl starch prodrug for inhibiting the growth and metastasis of prostate cancer
Zhao, K., Li, D., Xu, W., Ding, J., Jiang, W., Li, M., Wang, C., & Chen, X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.030 · Cited by 119 · see citing works
Miyazaki, M., Yuba, E., Hayashi, H., Harada, A., & Kono, K. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00551 · Cited by 118 · see citing works
Luong, D., Kesharwani, P., Alsaab, H. O., Sau, S., Padhyé, S., Sarkar, F. H., & Iyer, A. K. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.06.025 · Cited by 110 · see citing works
Self-citationNatural products for combating multidrug resistance in cancer
Chen, T., Xiao, Z., Liu, X., Wang, T., Wang, Y., Ye, F., Su, J., Yao, X., Xiong, L., & Yang, D. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107099 · Cited by 115 · see citing works
Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization
Yang, C., Mu, G., Zhang, Y., Gao, Y., Zhang, W., Liu, J., Zhang, W., Li, P., Yang, L., Yang, Z., et al. (2022) · Advanced Materials · doi:10.1002/adma.202202625 · Cited by 101 · see citing works
Füredi, A., Szebényi, K., Tóth, S., Cserepes, M., Hámori, L., Nagy, V., Karai, E., Vajdovich, P., Imre, T., Szabó, P., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.010 · Cited by 100 · see citing works
Gawde, K. A., Sau, S., Tatiparti, K., Kashaw, S. K., Mehrmohammadi, M., Azmi, A. S., & Iyer, A. K. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.03.046 · Cited by 100 · see citing works
Self-citationWang, J., Zhao, W., Zhang, Z., Liu, X., Xie, T., Wang, L., Xue, Y., & Zhang, Y. (2024) · Advanced Materials · doi:10.1002/adma.202308915 · Cited by 102 · see citing works
Zardad, A.-Z., Choonara, Y. E., du Toit, L. C., Kumar, P., Mabrouk, M., Kondiah, P. P. D., & Pillay, V. (2016) · Polymers · doi:10.3390/polym8100359 · Cited by 98 · see citing works
Gupta, V., & Trivedi, P. (2018) · Lipid Nanocarriers for Drug Targeting · doi:10.1016/b978-0-12-813687-4.00015-3 · Cited by 96 · see citing works
Ren, Y. T., Wang, R., Gao, L., Li, K., Zhou, X., Guo, H. B., Liu, C., Han, D., Tian, J., Ye, Q., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.008 · Cited by 94 · see citing works
Sana, B., Finne‐Wistrand, A., & Pappalardo, D. (2022) · Materials Today Chemistry · doi:10.1016/j.mtchem.2022.100963 · Cited by 93 · see citing works
El-Kayal, M., Nasr, M., Elkheshen, S. A., & Mortada, N. D. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.104972 · Cited by 91 · see citing works
Yang, X., Iyer, A. K., Singh, A., Milane, L. S., Choy, E., Hornicek, F. J., Amiji, M. M., & Duan, Z. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1602-1 · Cited by 89 · see citing works
Self-citationMalarvizhi, G. L., Retnakumari, A. P., Nair, S. V., & Koyakutty, M. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.05.011 · Cited by 90 · see citing works
Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances
Ertaş, Y. N., Dorcheh, K. A., Akbari, A., & Jabbari, E. (2021) · Nanomaterials · doi:10.3390/nano11071755 · Cited by 90 · see citing works
Lim, S. H., Wong, T. W., & Tay, W. X. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103094 · Cited by 89 · see citing works
Surface Engineering of Nanoparticles for Targeted Delivery to Hepatocellular Carcinoma
Lu, J., Wang, J., & Ling, D. (2017) · Small · doi:10.1002/smll.201702037 · Cited by 87 · see citing works
Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics
Yáng, Z., Dai, Y., Shan, L., Shen, Z., Wang, Z., Yung, B. C., Jacobson, O., Liu, Y., Tang, W., Wang, S., et al. (2018) · Nanoscale Horizons · doi:10.1039/c8nh00307f · Cited by 87 · see citing works
Sui, H. X., Zhu, L., Deng, W., & Li, Q. (2014) · Oncology Research and Treatment · doi:10.1159/000367802 · Cited by 86 · see citing works
Dixit, N., Vaibhav, K., Pandey, R. S., Jain, U. K., Katare, O. P., Katyal, A., & Madan, J. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.10.016 · Cited by 83 · see citing works
Komorowska, D., Radzik, T., Kalenik, S., & Rodacka, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810627 · Cited by 82 · see citing works
Kovács, D., Szöke, K., Igaz, N., Spengler, G., Molnár, J., Tóth, T., Madarász, D., Rázga, Z., Kónya, Z., Boros, I., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.015 · Cited by 81 · see citing works
Zhao, D., Zhang, H., Yang, S., He, W., & Luan, Y. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.10.029 · Cited by 79 · see citing works
Yu, W., Hu, C., & Gao, H. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113909 · Cited by 80 · see citing works
Restoration of chemosensitivity by multifunctional micelles mediated by P-gp siRNA to reverse MDR
Shen, J., Wang, Q., Hu, Q., Li, Y., Tang, G., & Chu, P. K.-H. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.035 · Cited by 78 · see citing works
Arabzadeh, A., Mortezazadeh, T., Aryafar, T., Gharepapagh, E., Majdaeen, M., & Farhood, B. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02099-0 · Cited by 76 · see citing works
Advances in thermosensitive polymer-grafted platforms for biomedical applications
Le, P. N., Huynh, C. K., & Trân, N. Q. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.02.006 · Cited by 73 · see citing works
Macrophage-targeted delivery systems for nucleic acid therapy of inflammatory diseases
Singh, A. K., Talekar, M., Raikar, A., & Amiji, M. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.021 · Cited by 72 · see citing works
Self-citationAmini, M. A., Abbasi, A. Z., Cai, P., Lip, H., Gordijo, C. R., Li, J., Chen, B., Zhang, L., Rauth, A. M., & Wu, X. Y. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy131 · Cited by 70 · see citing works
Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance
Xie, P., Wang, Y., Wei, D., Zhang, L., Zhang, B., Xiao, H., Song, H., & Mao, X. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00753j · Cited by 70 · see citing works
Haggag, Y. A., Ras, B. A., El‐Tanani, Y., Tambuwala, M. M., McCarron, P. A., Isreb, M., & El‐Tanani, M. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1813714 · Cited by 70 · see citing works
Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors
Xie, M., Gong, T., Wang, Y., Li, Z., Lu, M., Luo, Y. W., Min, L., Tu, C., Zhang, X., Zeng, Q., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084139 · Cited by 73 · see citing works
Maiolino, S., Russo, A., Pagliara, V., Conte, C., Ungaro, F., Russo, G., & Quaglia, F. (2015) · Journal of Nanobiotechnology · doi:10.1186/s12951-015-0088-2 · Cited by 70 · see citing works
Gawde, K. A., Kesharwani, P., Sau, S., Sarkar, F. H., Padhyé, S., Kashaw, S. K., & Iyer, A. K. (2017) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2017.01.092 · Cited by 69 · see citing works
Self-citationRecent advances of biomimetic nano-systems in the diagnosis and treatment of tumor
Li, A., Zhao, J., Fu, J., Cai, J., & Zhang, P. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.08.001 · Cited by 69 · see citing works
Oral lipid nanomedicines: Current status and future perspectives in cancer treatment
Moukhtari, S. H. E., Rodríguez‐Nogales, C., & Blanco‐Prieto, M. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.004 · Cited by 72 · see citing works
Lamch, Ł., Pucek, A., Kulbacka, J., Chudy, M., Jastrzębska, E., Tokarska, K., Bułka, M., Brzózka, Z., & Wilk, K. (2018) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2018.09.002 · Cited by 59 · see citing works
Ligand-based active targeting strategies for cancer theranostics
Bandyopadhyay, A., Das, T., Nandy, S., Sahib, S., Preetam, S., Gopalakrishnan, A. V., & Dey, A. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02612-4 · Cited by 66 · see citing works
Doustmihan, A., Fathi, M., Mazloomi, M., Salemi, A., Hamblin, M. R., & Jahanban‐Esfahlan, R. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.029 · Cited by 67 · see citing works
Cui, X., Sun, Y., Shen, M., Song, K., Yin, X., Di, W. J., & Duan, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19183 · Cited by 66 · see citing works
Huang, Y., Cole, S. P. C., Cai, T., & Cai, Y. (2016) · Oncology Letters · doi:10.3892/ol.2016.4596 · Cited by 65 · see citing works
Bhise, K., Sau, S., Alsaab, H. O., Kashaw, S. K., Tekade, R. K., & Iyer, A. K. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0062 · Cited by 63 · see citing works
Self-citationLiposomal nanomedicines in the treatment of prostate cancer
Kroon, J., Metselaar, J. M., Storm, G., & van der Pluijm, G. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.10.005 · Cited by 63 · see citing works
Aghanejad, A., Babamiri, H., Adibkia, K., Barar, J., & Omidi, Y. (2018) · Bioimpacts · doi:10.15171/bi.2018.14 · Cited by 61 · see citing works
Lou, H., Chu, L., Zhou, W., Dou, J., Teng, X., Tan, W., & Zhou, B. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01015a · Cited by 61 · see citing works
Singh, A., Talekar, M., Tran, T.-H., Samanta, A., Sundaram, R., & Amiji, M. M. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01083c · Cited by 60 · see citing works
Self-citationZhang, X., Wang, C., Wang, X., Zhong, T., Zhao, Y., Zhang, W.-Q., Ren, W., Huang, D., Zhang, S., Guo, Y., et al. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s79840 · Cited by 60 · see citing works
Aquib, M., Farooq, M. A., Banerjee, P., Akhtar, F., Filli, M. S., Boakye‐Yiadom, K. O., Kesse, S., Raza, F., Maviah, M. B. J., Mavlyanova, R., et al. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36770 · Cited by 59 · see citing works
Design attributes of long-circulating polymeric drug delivery vehicles
Beck‐Broichsitter, M., Nicolas, J., & Couvreur, P. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.033 · Cited by 57 · see citing works
Cheng, F., Wang, S., Zheng, H., Yang, S., Zhou, L., Liu, K., Zhang, Q., & Zhang, H. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111878 · Cited by 57 · see citing works
Dextran Sulfate Nanocarriers: Design, Strategies and Biomedical Applications
Ramasundaram, S., Saravanakumar, G., Sobha, S., & Oh, T. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010355 · Cited by 57 · see citing works
Wang, T., Guo, Y., He, Y., Ren, T., Yin, L., Fawcett, J. P., Gu, J., & Huimin, S. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.02.001 · Cited by 56 · see citing works
Polymeric Nanoparticles for Cancer Photodynamic Therapy
Conte, C., Maiolino, S., Pellosi, D. S., Miro, A., Ungaro, F., & Quaglia, F. (2015) · Topics in current chemistry · doi:10.1007/978-3-319-22942-3_3 · Cited by 56 · see citing works
- Authors
- Iyer, A. K., Singh, A., Ganta, S., & Amiji, M. M.
- Affiliations
- Northeastern University (US)
- Nemucore Medical Innovations (United States) (US)
- Corresponding author
- Amiji, Mansoor M.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 65
- Issue
- 13-14
- Pages
- 1784-1802
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2000798536
- Cited by
- 343
- References
- 242
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 31 · 2023: 26 · 2022: 28 · 2021: 32 · 2020: 26 · 2019: 33 · 2018: 30 · 2017: 31 · 2016: 33 · 2015: 23 · 2014: 27 · 2013: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Update notices
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- cancer nanomedicine, multidrug resistance, drug resistance, multifunctional nanoparticles, targeted drug delivery, cancer stem cells, efflux pumps, stimuli-responsive nanoparticles, tumor hypoxia, aerobic glycolysis, tumor recurrence
- MeSH terms
- Animals, Antineoplastic Agents, Drug Carriers, Humans, Neoplasms, Drug Delivery Systems, Drug Resistance, Neoplasm, Nanomedicine, Nanoparticles, Molecular Targeted Therapy
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