The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.
Year‐long Changes in Protein Metabolism in Elderly Men and Women Supplemented With a Nutrition Cocktail of β‐Hydroxy‐β‐methylbutyrate (HMB), L‐Arginine, and L‐Lysine
Abstract
Background: A major contributing factor to the loss of mobility in elderly people is the gradual and continuous loss of lean body mass. Objectives: To determine whether supplementation of an amino acid cocktail daily for 1 year could improve the age‐associated changes in protein turnover and lean body mass in elderly people. Design: Elderly (76± 1.6 years) women (n = 39) and men (n = 38) were recruited for a double‐blinded controlled study. Study participants were randomly assigned to either an isonitrogenous control‐supplement (n = 37) or a treatment‐supplement (HMB/Arg/Lys) consisting of β‐hydroxy‐β‐methylbutyrate, L‐arginine, and L‐lysine (n = 40) for the 1‐year study. Lean tissue mass was measured using both bioelectrical‐impedance analysis (BIA) and dual energy x‐ray absorptiometry (DXA). Rates of whole‐body protein turnover were estimated using primed/intermittent oral doses of 15 N‐glycine. Results: In subjects taking the HMB/Arg/Lys supplement, lean tissue increased over the year of study while in the control group, lean tissue did not change. Compared with control, HMB/Arg/Lys increased body cell mass (BIA) by 1.6% (P = .002) and lean mass (DXA) by 1.2% (P = .05). The rates of protein turnover were significantly increased 8% and 12% in the HMB/Arg/Lys‐supplemented group while rates of protein turnover decreased 11% and 9% in the control‐supplemented subjects (P < .01), at 3 and 12 months, respectively. Conclusions: Consumption of a simple amino acid‐related cocktail increased protein turnover and lean tissue in elderly individuals in a year‐long study.
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“In general, these agents have positive effects on lean body mass and strength, but the effects tend to be small and are not consistent.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [176]
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Metadata
- Authors
- Baier, S., Johannsen, D., Abumrad, N., Rathmacher, J. A., Nissen, S., & Flakoll, P.
- Affiliations
- Iowa State University (US)
- Vanderbilt University Medical Center (US)
- Corresponding author
- Nissen, Steven
- Venue
- Journal of Parenteral and Enteral Nutrition
- Publisher
- Wiley
- Published
- 2008-10-02
- Volume
- 33
- Issue
- 1
- Pages
- 71-82
- ISSN
- 0148-6071 (ISSN-L)
- 1941-2444
- OpenAlex
- W2047767140
- Cited by
- 133
- References
- 61
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Parenteral and Enteral Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r44ag020897-03)
- National Institute on Aging (R44AG20897)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- protein metabolism, protein turnover, lean body mass, older adults, beta-hydroxy-beta-methylbutyrate, L-arginine, L-lysine, amino acid supplementation, sarcopenia, body cell mass, aging
- MeSH terms
- Aged, Aged, 80 and over, Aging, Arginine, Body Composition, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Lysine, Male, Patient Compliance, Proteins, Surveys and Questionnaires, Valerates, Muscle, Skeletal, Dietary Supplements
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