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Cited by 133Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.

Year‐long Changes in Protein Metabolism in Elderly Men and Women Supplemented With a Nutrition Cocktail of β‐Hydroxy‐β‐methylbutyrate (HMB), L‐Arginine, and L‐Lysine

Baier, Shawn, Johannsen, Darcy, Abumrad, Naji, Rathmacher, John A., Nissen, Steven, Flakoll, Paul·2009·Journal of Parenteral and Enteral Nutrition
DOI 10.1177/0148607108322403
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Abstract

Background: A major contributing factor to the loss of mobility in elderly people is the gradual and continuous loss of lean body mass. Objectives: To determine whether supplementation of an amino acid cocktail daily for 1 year could improve the age‐associated changes in protein turnover and lean body mass in elderly people. Design: Elderly (76± 1.6 years) women (n = 39) and men (n = 38) were recruited for a double‐blinded controlled study. Study participants were randomly assigned to either an isonitrogenous control‐supplement (n = 37) or a treatment‐supplement (HMB/Arg/Lys) consisting of β‐hydroxy‐β‐methylbutyrate, L‐arginine, and L‐lysine (n = 40) for the 1‐year study. Lean tissue mass was measured using both bioelectrical‐impedance analysis (BIA) and dual energy x‐ray absorptiometry (DXA). Rates of whole‐body protein turnover were estimated using primed/intermittent oral doses of 15 N‐glycine. Results: In subjects taking the HMB/Arg/Lys supplement, lean tissue increased over the year of study while in the control group, lean tissue did not change. Compared with control, HMB/Arg/Lys increased body cell mass (BIA) by 1.6% (P = .002) and lean mass (DXA) by 1.2% (P = .05). The rates of protein turnover were significantly increased 8% and 12% in the HMB/Arg/Lys‐supplemented group while rates of protein turnover decreased 11% and 9% in the control‐supplemented subjects (P < .01), at 3 and 12 months, respectively. Conclusions: Consumption of a simple amino acid‐related cocktail increased protein turnover and lean tissue in elderly individuals in a year‐long study.

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Crossref · 10.1177/0148607108322403

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Research works printed but not linked: 2

  1. Nissen S, 1996, Effect ofβ ‐hydroxy‐β‐methyl butyrate (HMB) supplementation on strength and body composition of trained and untrained males undergoing intense resistance training, FASEB J., 10, A287
  2. Balagopal P, 1997, Effects of aging on in vivo synthesis of skeletal muscle myosin heavy‐chain and sarcoplasmic protein in humans, Am J Physiol., 273, E790

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Metadata

Authors
Baier, S., Johannsen, D., Abumrad, N., Rathmacher, J. A., Nissen, S., & Flakoll, P.
Affiliations
  • Iowa State University (US)
  • Vanderbilt University Medical Center (US)
Corresponding author
Nissen, Steven
ORCID
Venue
Journal of Parenteral and Enteral Nutrition
Publisher
Wiley
Published
2008-10-02
Volume
33
Issue
1
Pages
71-82
ISSN
  • 0148-6071 (ISSN-L)
  • 1941-2444
DOI
10.1177/0148607108322403
OpenAlex
W2047767140
Cited by
133
References
61
Citations by year
2026: 5 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 7 · 2013: 12 · 2012: 8
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Parenteral and Enteral Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r44ag020897-03)
  • National Institute on Aging (R44AG20897)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
protein metabolism, protein turnover, lean body mass, older adults, beta-hydroxy-beta-methylbutyrate, L-arginine, L-lysine, amino acid supplementation, sarcopenia, body cell mass, aging
MeSH terms
Aged, Aged, 80 and over, Aging, Arginine, Body Composition, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Lysine, Male, Patient Compliance, Proteins, Surveys and Questionnaires, Valerates, Muscle, Skeletal, Dietary Supplements

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