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Cited by 194Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentBurn Injury Management and Outcomes

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Oral Glutamine Decreases Bacterial Translocation and Improves Survival in Experimental Gut‐Origin Sepsis

Gianotti, Luca, Alexander, J. Wesley, Gennari, Roberto, Pyles, Tonyia, Babcock, George F.·1995·Journal of Parenteral and Enteral Nutrition
DOI 10.1177/014860719501900169
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Abstract

Background: Glutamine has been shown to be an important dietary component for the maintenance of gut metabolism. The purpose of this study was to assess the potential benefit of glutamine‐enriched diets on experimental gut‐derived sepsis. Methods: BALB/c mice were fed either 2% glutamine‐supplemented or 1% glycine‐supplemented (near‐isonitrogenous control) AIN‐76A diets. Control mice received either nonsupplemented AIN‐76A or regular Purina Rodent Laboratory Mouse Chow 5001 diets. After 10 days of feeding, the mice were transfused with allogeneic blood (from C3H/HeJ mice), and the feeding protocols were continued for an additional 5 days. The mice then underwent gavage with 10 10 Escherichia coli labeled with either indium‐111 oxine or [14 C]glucose followed immediately by a 20% burn injury. Some mice were observed 10 days postburn for survival rates. Others were killed 4 hours after burn, and the mesenteric lymph nodes, liver, and spleen were harvested to determine radionuclide and bacterial colony counts. The percentages of viable translocated E coli were also calculated. Results: Mice fed glutamine‐enriched diets had a lower degree of translocation (as measured by both radionuclide and bacterial counts) to the tissues than did the other groups and had an improvement in the ability to kill translocated E coli (as measured by the percentage of viable bacteria). Survival was significantly higher in the group fed 2% glutamine (81%) compared with the groups fed 1% glycine (36%), AIN‐76A (35%), and Purina Rodent Laboratory Mouse Chow 5001 (36%) diets (p <.004). Conclusions: Glutamine‐supplemented enteral diets may exert important benefits in preventing gut‐origin sepsis after trauma (Journal of Parenteral and Enteral Nutrition 19:69–74, 1995)

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Crossref · 10.1177/014860719501900169

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Research works printed but not linked: 1

  1. Gianotti L., 1993, Prostaglandin E, analogues misoprostal and enisoprost decrease microbial transolocation and modulate the immune response, Circ Shock, 40, 243

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Metadata

Authors
Gianotti, L., Alexander, J. W., Gennari, R., Pyles, T., & Babcock, G. F.
Affiliations
  • University of Milan (IT)
  • University of Cincinnati (US)
ORCID
Venue
Journal of Parenteral and Enteral Nutrition
Publisher
Wiley
Published
1995-01
Volume
19
Issue
1
Pages
69-74
ISSN
  • 0148-6071 (ISSN-L)
  • 1941-2444
DOI
10.1177/014860719501900169
OpenAlex
W2027495250
Cited by
194
References
29
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 13 · 2013: 5 · 2012: 4
FWCI
12.84
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Parenteral and Enteral Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Funders
  • National Institutes of Health (5r01ai012936-20)
  • National Institute of Allergy and Infectious Diseases (AI12936)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
Keywords
glutamine supplementation, bacterial translocation, Escherichia coli, burns, enteral nutrition, glycine, survival, mesenteric lymph nodes
MeSH terms
Animals, Burns, Enteral Nutrition, Escherichia coli, Escherichia coli Infections, Female, Glutamine, Indium Radioisotopes, Liver, Lymph Nodes, Mice, Inbred BALB C, Mice, Inbred C3H, Spleen, Colony Count, Microbial, Mice

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