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Cited by 55Frailty in Older AdultsAging, Health, and DisabilityAging and Gerontology Research

Dynamics of frailty and ADL dependence in a five-year longitudinal study of octogenarians

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Guilley, Edith, Ghisletta, Paolo, Armi, Franca, Berchtold, André, d'Epinay, Christian Lalive, Michel, Jean-Pierre, de Ribaupierre, Anik·2008·Research on Aging
DOI 10.1177/0164027507312115
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Abstract

Using a sample of octogenarians from the Swiss Interdisciplinary Longitudinal Study on the Oldest Old, the authors investigated the predictive validity of an expanded working definition of frailty based on deficiencies in mobility, memory, energy, and physical or sensory capacities and analyzed the resulting health transitions. The five domains were considered as predictors of the onset of dependence in activities of daily living (ADLs) and death using logistic multilevel and Cox survival regression models. Health transitions were studied with Markov chains. Deficiencies in memory, energy, and sensory capacities contributed to the prediction of the onset of ADL dependence and death in participants free of physical pains and mobility impairments. With two domains affected, frailty in very old persons indicated an increased risk of adverse outcomes. The study of transitions showed that ADL-independent frailty was a highly probable and relatively long transitional stage between robustness and ADL dependence.

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  • The Frailty Index defines frailty using 92 baseline items-symptoms, signs, abnormal labs, diseases and disabilities-referred to as deficits.

    “Ninety-two baseline parameters of symptoms (e.g. low mood), signs (e.g. tremor) and abnormal laboratory values, disease states and disabilities, collectively referred to as deficits, were used to define frailty (75).”

    From Frailty in elderly people (2013) · cites this paper as [75]

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Authors
Guilley, E., Ghisletta, P., Armi, F., Berchtold, A., d'Epinay, C. L., Michel, J.-P., & de Ribaupierre, A.
Affiliations
  • University of Geneva (CH)
  • University of Lausanne (CH)
  • University of Geneva
  • University Hospital of Geneva (CH)
  • University of Geneva, University of Lausanne
ORCID
Venue
Research on Aging
Publisher
SAGE Publications
Published
2008-02-08
Volume
30
Issue
3
Pages
299-317
ISSN
  • 0164-0275 (ISSN-L)
  • 1552-7573
DOI
10.1177/0164027507312115
OpenAlex
W2131523679
Cited by
55
References
40
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 1 · 2014: 3 · 2013: 8 · 2012: 2
FWCI
1.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Research on Aging (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Keywords
frailty, activities of daily living dependence, octogenarians, oldest old, health transition, memory impairment, energy deficiency, sensory capacity, mobility impairment, mortality, Markov chain model

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