Individual Differences in Response to Supervised Exercise Therapy for Peripheral Artery Disease
Open accessAbstract
Nonresponse to exercise has been extensively examined in young athletes but is seldom reported in studies of aerobic exercise interventions in older adults. This study examined the prevalence of nonresponse and poor response to exercise in functional and quality of life outcomes and response patterns between and among older adults undergoing 12-weeks of supervised exercise therapy for the management of peripheral artery disease ( N = 44, mean age 72.3 years, 47.7% female). The prevalence of nonresponse (no change/decline in performance) in walking distance was 31.8%. The prevalence of poor response (lack of a clinically meaningful improvement) was 43.2%. Similar patterns of response were observed in both objective and patient-reported measures of physical function. All participants improved in at least one outcome; only two participants improved in all measured outcomes. Additional research should examine modifiable predictors of response to inform programming and maximize an individual’s potential benefit from exercise therapy.
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Whipple et al. reported a high prevalence of non-responders among individuals with peripheral artery disease, with or without T2D, who completed at least two-thirds of their prescribed exercise sessions.
“Whipple et al. [617] reported a high prevalence of non-responders among individuals with peripheral artery disease, with or without T2D, who completed at least two-thirds of their prescribed exercise sessions.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [617]
Whipple et al. reported a high prevalence of non-responders among individuals with peripheral artery disease, with or without T2D, who completed at least two-thirds of prescribed exercise sessions.
“Whipple et al. [617] reported a high prevalence of non-responders among individuals with peripheral artery disease, with or without T2D, who completed at least two-thirds of their prescribed exercise sessions.”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [617]
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- Authors
- Whipple, M. O., Schorr, E. N., Talley, K. M. C., Wolfson, J., Lindquist, R., Bronas, U. G., & Treat-Jacobson, D.
- Affiliations
- University of Minnesota (US)
- University of Illinois Chicago (US)
- School of Nursing, University of Minnesota – Twin Cities, Minneapolis, MN, USA
- Corresponding author
- Whipple, Mary O.
- Venue
- Western Journal of Nursing Research
- Publisher
- SAGE Publications
- Published
- 2020-12-17
- Volume
- 43
- Issue
- 8
- Pages
- 770-784
- ISSN
- 0193-9459 (ISSN-L)
- 1552-8456
- PMC
- PMC8209120
- OpenAlex
- W3113564993
- Cited by
- 6
- References
- 32
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Western Journal of Nursing Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Advancing Translational Sciences (UL1TR002494)
- National Hartford Center of Gerontological Nursing Excellence (2015-2017 Patricia G. Archbold Predoctoral Scholar)
- national institute on aging (T32AG000279)
- Midwest Nursing Research Society (2017 MNRS/CANS Dissertation Research Grant)
- National Institute of Nursing Research (F31NR016614)
- Topics
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- peripheral arterial disease, supervised exercise therapy, individual differences, treatment response, older adults, walking distance, physical function, quality of life, predictors of treatment response
- MeSH terms
- Aged, Exercise Therapy, Female, Humans, Individuality, Intermittent Claudication, Male, Quality of Life, Walking, Peripheral Arterial Disease
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