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Cited by 34Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesSchizophrenia research and treatment

A Double-Blind, Randomized, 26-Week Study Comparing the Cognitive and Psychomotor Effects and Efficacy of 75 mg (37.5 mg b.i.d.) Venlafaxine and 75 mg (25 mg Mane, 50 mg Nocte) Dothiepin in Elderly Patients with Moderate Major Depression Being Treated in General Practice

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Trick, Leanne, Stanley, Neil, Rigney, Una, Hindmarch, Ian·2004·Journal of Psychopharmacology
DOI 10.1177/0269881104042622
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Abstract

To investigate the efficacy and cognitive and psychomotor effects of venlafaxine and dothiepin in elderly patients with moderate major depression. A prospective, randomized, double-blind, parallel-group, active comparator controlled study was conducted. Eighty-eight patients (aged ≥ 60 years) were enrolled. Each patient received either venlafaxine (immediate release formulation) 37.5 mg twice per day or dothiepin 25 mg mane followed by 50 mg nocte for 26 weeks. Efficacy was assessed with the Montgomery-Asberg Depression Rating Scale and the Hamilton Depression Rating Scale. A psychometric test battery to assess cognitive function, activities of daily living and sleep consisted of Critical Flicker Fusion (CFF), Short-term Memory - Kim’s Game, Cognitive Failures Questionnaire, Milford Epworth Sleepiness Scale, Leeds Sleep Evaluation Questionnaire, and an Accident Scoring Questionnaire. Quality of Life Questionnaires (Short Form 36 and Quality of Life in Depression Scale) were also administered. Venlafaxine significantly ( p < 0.05) raised CFF scores compared to baseline but had no effect on any other measure. Dothiepin significantly ( p < 0.05) lowered CFF threshold, and increased ratings of both sedation and difficulty in waking. The results showed that venlafaxine at doses of 37.5 mg b.i.d. in elderly depressed patients is free from disruptive effects on cognitive function and psychomotor performance.

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Crossref · 10.1177/0269881104042622

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  • After removing the venlafaxine versus dothiepin trial (Trick et al., 2004), SSRIs/SNRIs have a statistically significant greater effect on memory compared to TCAs (SMD 0.58; 95% CI 0.31-0.84; p < 0.00001; I2 = 0%).

    “when removing one study evaluating venlafaxine versus dothiepin (Trick et al., 2004), which appeared to be divergent from the other studies, I2 became 0% and the SMD rose to 0.58 (95% CI 0.31 to 0.84; p < 0.00001) in favor of SSRIs/SNRIs”

    From The Cognitive Effects of Antidepressants in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Clinical Trials (2016) · cites this paper as Trick et al., 2004

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Authors
Trick, L., Stanley, N., Rigney, U., & Hindmarch, I.
Affiliations
University of Surrey (GB)
Corresponding author
Trick, Leanne
ORCID
Venue
Journal of Psychopharmacology
Publisher
SAGE Publications
Published
2004-06
Volume
18
Issue
2
Pages
205-214
ISSN
  • 0269-8811 (ISSN-L)
  • 1461-7285
DOI
10.1177/0269881104042622
OpenAlex
W2087216612
Cited by
34
References
55
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 5 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
1.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Durham Research Online (Durham University) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
venlafaxine, dothiepin, geriatric depression, major depressive disorder, cognitive function, psychomotor performance, critical flicker fusion, sleepiness, sedation, quality of life, antidepressant efficacy, general practice
MeSH terms
Venlafaxine Hydrochloride, Aged, Cognition, Cyclohexanols, Depressive Disorder, Dizziness, Dothiepin, Double-Blind Method, Drug Administration Schedule, Female, Flicker Fusion, Humans, Disorders of Excessive Somnolence, Male, Narcolepsy, Nausea, Psychometrics, Psychomotor Performance, Time Factors

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