Perturbed reward processing in pediatric bipolar disorder: an antisaccade study
Open accessAbstract
Pediatric bipolar disorder is a severe and impairing illness. Characterizing the impact of pediatric bipolar disorder on cognitive function might aid in understanding the phenomenology of the disorder. While previous studies of pediatric bipolar disorder have reported deficits in cognitive control and reward behavior, little is understood about how affective processes influence behavioral control. Relative to prior studies using manual-response paradigms, eye movement tasks provide a more precise assessment of reward sensitivity and cognitive and motor control. The current study compares 20 youths with bipolar disorder (mean age = 13.9 years ± 2.22) and 23 healthy subjects (mean age = 13.8 years ± 2.49) on a mixed pro—antisaccade task with monetary incentives. On both types of saccades, participants were presented with three types of incentives: those where subjects can win money, lose money, or neither win nor lose money. Impaired reward processing was found in youths with bipolar disorder relative to controls, particularly on antisaccades. This difference was reflected in lower error rates during incentive trials in the control but not in the bipolar disorder group. By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder.
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Reward motivation is atypical in individuals with bipolar disorder, as shown by a self-report measure of reward responsivity and eye-tracking studies of monetary gains and losses.
“Reward motivation is also atypical in individuals with bipolar disorder, as shown by a self-report measure of reward responsivity [269] and in eye-tracking studies of monetary gains and losses [270].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [270]
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- Authors
- Mueller, S. C., Ng, P., Temple, V., Hardin, M. G., Pine, D. S., Leibenluft, E., & Ernst, M.
- Affiliations
- National Institutes of Health (US)
- Section of Developmental and Affective Neuroscience National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
- Corresponding author
- Mueller, Sven C
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2010-01-15
- Volume
- 24
- Issue
- 12
- Pages
- 1779-1784
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- PMC
- PMC2999669
- OpenAlex
- W2146835550
- Cited by
- 42
- References
- 32
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 6
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health (Z01MH002778)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- pediatric bipolar disorder, reward processing, antisaccade task, prosaccade task, financial incentives, cognitive control, eye movements, error rate, emotional processing
- MeSH terms
- Adolescent, Bipolar Disorder, Child, Cognition Disorders, Female, Humans, Male, Psychomotor Performance, Reward, Saccades, Case-Control Studies
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