The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
One-Year Follow-up of Platelet-Rich Plasma Treatment in Chronic Achilles Tendinopathy: A Double-Blind Randomized Placebo-Controlled Trial
Abstract
Background: Achilles tendinopathy is a common disease among both athletes and in the general population in which the use of platelet-rich plasma has recently been increasing. Good evidence for the use of this autologous product in tendinopathy is limited, and data on longer-term results are lacking. Purpose: To study the effects of a platelet-rich plasma injection in patients with chronic midportion Achilles tendinopathy at 1-year follow-up. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Fifty-four patients, aged 18 to 70 years, with chronic tendinopathy 2 to 7 cm proximal to the Achilles tendon insertion were randomized to receive either a blinded injection containing platelet-rich plasma or saline (placebo group) in addition to an eccentric training program. The main outcome was the validated Victorian Institute of Sports Assessment–Achilles score. Patient satisfaction was recorded and ultrasound examination performed at baseline and follow-up. Results: The mean Victorian Institute of Sports Assessment–Achilles score improved in both the platelet-rich plasma group and the placebo group after 1 year. There was no significant difference in increase between both groups (adjusted between-group difference, 5.5; 95% confidence interval, –4.9 to 15.8, P = .292). In both groups, 59% of the patients were satisfied with the received treatment. Ultrasonographic tendon structure improved significantly in both groups but was not significantly different between groups (adjusted between-group difference, 1.2%; 95% confidence interval, –4.1 to 6.6, P = .647). Conclusion: This randomized controlled trial showed no clinical and ultrasonographic superiority of platelet-rich plasma injection over a placebo injection in chronic Achilles tendinopathy at 1 year combined with an eccentric training program.
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Citations
Cites
Heavy-Load Eccentric Calf Muscle Training For the Treatment of Chronic Achilles Tendinosis
Alfredson, H., Pietilä, T., Jonsson, P., & Lorentzon, R. (1998) · The American Journal of Sports Medicine · doi:10.1177/03635465980260030301 · Cited by 1,199
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Histopathology of Common Tendinopathies: Update and Implications for Clinical Management
Khan, K. M., Cook, J. L., Bonar, F., Harcourt, P., & ??strom, M. (1999) · Sports Medicine · doi:10.2165/00007256-199927060-00004 · Cited by 982
Treatment of Chronic Elbow Tendinosis with Buffered Platelet-Rich Plasma
Mishra, A., & Pavelko, T. (2006) · The American Journal of Sports Medicine · doi:10.1177/0363546506288850 · Cited by 913
Platelet-Rich Plasma Injection for Chronic Achilles Tendinopathy: A Randomized Controlled Trial
de Vos, R. J., Weir, A., van Schie, H. T. M., Bierma-Zeinstra, S. M. A., Verhaar, J. A. N., Weinans, H., & Tol, J. L. (2010) · JAMA · doi:10.1001/jama.2009.1986 · Cited by 834
Self-citationOveruse tendon conditions: Time to change a confusing terminology
Maffulli, N. (1998) · Arthroscopy: The Journal of Arthroscopic & Related Surgery · doi:10.1016/s0749-8063(98)70021-0 · Cited by 752
Peerbooms, J. C., Sluimer, J., Bruijn, D. J., & Gosens, T. (2010) · The American Journal of Sports Medicine · doi:10.1177/0363546509355445 · Cited by 689
Treatment of Tendinopathy: What Works, What Does Not, and What is on the Horizon
Andres, B. M., & Murrell, G. A. C. (2008) · Clinical Orthopaedics & Related Research · doi:10.1007/s11999-008-0260-1 · Cited by 538
Castricini, R., Longo, U. G., De Benedetto, M., Panfoli, N., Pirani, P., Zini, R., Maffulli, N., & Denaro, V. (2011) · The American Journal of Sports Medicine · doi:10.1177/0363546510390780 · Cited by 487
Can Platelet-Rich Plasma Enhance Tendon Repair?: A Cell Culture Study
de Mos, M., van der Windt, A. E., Jahr, H., van Schie, H. T. M., Weinans, H., Verhaar, J. A. N., & van Osch, G. J. V. M. (2008) · The American Journal of Sports Medicine · doi:10.1177/0363546508314430 · Cited by 423
Self-citation
Cited by
Chahla, J., Cinque, M. E., Piuzzi, N. S., Mannava, S., Geeslin, A. G., Murray, I. R., Dornan, G. J., Muschler, G. F., & LaPrade, R. F. (2017) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.16.01374 · Cited by 504
Chen, X., Jones, I. A., Park, C., & Vangsness, C. T. (2018) · The American Journal of Sports Medicine · doi:10.1177/0363546517743746 · Cited by 294
Tendinopathy: Is Imaging Telling Us the Entire Story?
Docking, S. I., Ooi, C. C., & Connell, D. (2015) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2015.5880 · Cited by 214
Zhou, Y., Zhang, J., Wu, H., Hogan, M. V., & Wang, J. H.-C. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0172-4 · Cited by 187
Yan, R., Gu, Y., Ran, J., Hu, Y., Zheng, Z., Zeng, M., Heng, B. C., Chen, X., Yin, Z., Chen, W., et al. (2017) · The American Journal of Sports Medicine · doi:10.1177/0363546517694357 · Cited by 124
Metadata
- Authors
- de Jonge, S., de Vos, R. J., Weir, A., van Schie, H. T. M., Bierma-Zeinstra, S. M. A., Verhaar, J. A. N., Weinans, H., & Tol, J. L.
- Venue
- The American Journal of Sports Medicine
- Publisher
- SAGE Publications
- Published
- 2011-05-21
- Volume
- 39
- Issue
- 8
- Pages
- 1623-1630
- ISSN
- 0363-5465 (ISSN-L)
- 1552-3365
- OpenAlex
- W2129382396
- Cited by
- 371
- References
- 32
- FWCI
- 27.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- de Jonge, S., de Vos, R. J., Weir, A., van Schie, H. T. M., Bierma-Zeinstra, S. M. A., Verhaar, J. A. N., Weinans, H., & Tol, J. L. (2011). One-Year Follow-up of Platelet-Rich Plasma Treatment in Chronic Achilles Tendinopathy: A Double-Blind Randomized Placebo-Controlled Trial. The American Journal of Sports Medicine. https://doi.org/10.1177/0363546511404877
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