The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament
Abstract
We report a biologic approach to improve medial collateral ligament healing using growth factors normally expressed in healing tissue. Our previous in vitro work demonstrated that platelet-derived growth factor-BB and transforming growth factor- 1 promoted fibroblast proliferation and matrix synthesis, respectively. Therefore, these growth factors were used in vivo to determine whether they could improve medial collateral ligament healing, whether this effect was dose-dependent, and if combinations of growth factors could improve healing more than individual growth factors. Thirty-seven rabbits had various doses of growth factors applied to the ruptured right medial collateral ligaments using a fibrin sealant delivery vehicle. The five groups consisted of 1) two groups receiving two doses of platelet-derived growth factor-BB, 2) two groups receiving two doses of this growth factor plus transforming growth factor- 1, and 3) one group receiving fibrin sealant only. After sacrifice at 6 weeks, biomechanical and histologic evaluations of the healing ligament were performed. Femur-medial collateral ligament-tibia complexes of the knees given the higher dose of platelet-derived growth factor-BB had ultimate load, energy absorbed to failure, and ultimate elongation values that were 1.6, 2.4, and 1.6 times greater than the same complexes of the control group. Adding transforming growth factor- 1 did not lead to any further increases in the structural properties of the complex compared with treatment with platelet-derived growth factor-BB. These encouraging results suggest that use of platelet-derived growth factor-BB may improve the quality of the healing medial collateral ligament, and that it may also have a similar potential for promoting healing of other ligaments.
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The Influence of Platelet-Rich Plasma on Angiogenesis During the Early Phase of Tendon Healing
Lyras, D. N., Kazakos, K., Verettas, D., Polychronidis, A., Tryfonidis, M., Botaitis, S., Agrogiannis, G., Simopoulos, C., Kokka, A., & Patsouris, E. (2009) · Foot & Ankle International · doi:10.3113/fai.2009.1101 · Cited by 147
Weiler, A., Förster, C., Hunt, P., Falk, R., Jung, T., Unterhauser, F. N., Bergmann, V., Schmidmaier, G., & Haas, N. P. (2004) · The American Journal of Sports Medicine · doi:10.1177/0363546503261711 · Cited by 131
Platelet-Rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology
Kia, C., Baldino, J., Bell, R., Ramji, A., Uyeki, C., & Mazzocca, A. (2018) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-018-9515-y · Cited by 94
Hildebrand, K. A., Deie, M., Allen, C. R., Smith, D. W., Georgescu, H. I., Evans, C. H., Robbins, P. D., & Woo, S. L. (1999) · Journal of Orthopaedic Research · doi:10.1002/jor.1100170107 · Cited by 94
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Watanabe, N., Woo, S. L., Papageorgiou, C., Celechovsky, C., & Takai, S. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10115 · Cited by 69
Self-citationYoshioka, T., Kanamori, A., Washio, T., Aoto, K., Uemura, K., Sakane, M., & Ochiai, N. (2013) · Knee Surgery, Sports Traumatology, Arthroscopy · doi:10.1007/s00167-012-2002-x · Cited by 61
Basic Science of Ligament Healing: Medial Collateral Ligament Healing With and Without Treatment
Creighton, R. A., Spang, J. T., & Dahners, L. E. (2005) · Sports Medicine and Arthroscopy Review · doi:10.1097/01.jsa.0000173623.62717.03 · Cited by 25
Lee, J. K., Jo, S., Lee, Y. L., Park, H., Song, J.-S., Sung, I.-H., & Kim, T.-H. (2020) · Scientific Reports · doi:10.1038/s41598-020-60047-w · Cited by 19
Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint
Lee, C.-S., Jeon, O.-H., Han, S.-B., & Jang, K.-M. (2023) · Medicina · doi:10.3390/medicina59040725 · Cited by 7
Metadata
- Authors
- Hildebrand, K. A., Woo, S. L.-Y., Smith, D. W., Allen, C. R., Deie, M., Taylor, B. J., & Schmidt, C. C.
- Venue
- The American Journal of Sports Medicine
- Publisher
- SAGE Publications
- Published
- 1998-07
- Volume
- 26
- Issue
- 4
- Pages
- 549-554
- ISSN
- 0363-5465 (ISSN-L)
- 1552-3365
- OpenAlex
- W2134093079
- Cited by
- 273
- References
- 1
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
