Pilot study: access to fitness facility and exercise levels in olanzapine-treated patients
Abstract
BACKGROUND: Increasingly alarmed by the health risks (that is, weight gain, elevated lipids, and poor glucose tolerance) posed by novel antipsychotic medications, clinicians who treat schizophrenia are attempting to help patients improve lifestyle factors. Unfortunately, schizophrenia research has neglected exercise as a legitimate adjunctive treatment for schizophrenia. OBJECTIVE: To assess the extent to which stable patients with schizophrenia would adhere to an exercise program if offered access to a fitness facility. METHODS: Ten of 20 stable patients with schizophrenia or schizoaffective disorder who were treated with olanzapine for at least 4 weeks had the opportunity to receive access to a Young Men's Christian Association (YMCA) fitness facility, based on random allocation. The intervention included a free membership to the YMCA for 6 months, with access to all the fitness amenities and equipment. The mean dosage of olanzapine was 11.5 mg daily for the YMCA group. RESULTS: Of the 10 subjects, 2 did not attend at all. One subject met criteria for full attendance for each of the 6 months and lost 15 Kg. Dropout rates were as follows: 90% at 6 months, 70% at 5 months, and 40% at 4 months. The main reason they gave for poor attendance was lack of motivation. The mean weight gain was 2 kg in the YMCA group. CONCLUSION: Most subjects did not regularly exercise or attend. They cited poor motivation as the main reason. The subject who exercised regularly lost a significant amount of weight.
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In patients, implementation and sustainability of regular exercise commitment remains problematic due to poor motivation, side effects of medications, social barriers, and symptoms.
“In patients implementation and sustainability of regular exercise commitment remains problematic due to poor motivation, 73 side effects of medications, 74,75 social barriers, 76 and symptoms. 73”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [73]
Cites
Stages of change and decisional balance for 12 problem behaviors.
Prochaska, J., Velicer, W., Rossi, J., Goldstein, M., Marcus, B., Rakowski, W., Fiore, C., Harlow, L., Redding, C. A., & Rosenbloom, D. (1994) · Health Psychology · doi:10.1037/0278-6133.13.1.39 · Cited by 2,579 · see citing works
Trân, P. V., Hamilton, S. H., Kuntz, A. J., Potvin, J. H., Andersen, S. W., Beasley, C. M., & Tollefson, G. D. (1997) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199710000-00010 · Cited by 712 · see citing works
Novel antipsychotics: comparison of weight gain liabilities.
Wirshing, D. A., Wirshing, W. C., Kysar, L., Berisford, M. A., Goldstein, D., Pashdag, J., Mintz, J., & Marder, S. R. (1999) · PubMed · Cited by 523 · see citing works
Atypical antipsychotics and weightgain — a systematic review
Taylor, D. M., & McAskill, R. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.101006416.x · Cited by 435 · see citing works
Wirshing, D. A., Wirshing, W. C., Kysar, L., Berisford, M. A., Goldstein, D., Pashdag, J., Mintz, J., & Marder, S. R. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0602 · Cited by 392 · see citing works
Tolerability of Atypical Antipsychotics
Stanniland, C., & Taylor, D. M. (2000) · Drug Safety · doi:10.2165/00002018-200022030-00004 · Cited by 303 · see citing works
Tollefson, G. D., Beasley, C. M., Tamura, R., Tran, P. V., & Potvin, J. H. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.9.1248 · Cited by 280 · see citing works
Olanzapine Increases Weight and Serum Triglyceride Levels
Osser, D. N., Najarian, D. M., & Dufresne, R. L. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n1109 · Cited by 231 · see citing works
Stahl, S. M. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0102 · Cited by 154 · see citing works
Physical and psychological consequences of weight gain.
Kawachi, I. (1999) · PubMed · Cited by 108 · see citing works
Colvin, R. H., & Olson, S. B. (1983) · Addictive Behaviors · doi:10.1016/0306-4603(83)90024-2 · Cited by 95 · see citing works
Maintenance of successful weight loss: incidence and prediction.
Marston, A., & Criss, J. (1984) · PubMed · Cited by 53 · see citing works
Nonpharmacologic and pharmacologic management of weight gain.
Greenberg, I., Chan, S., & Blackburn, G. L. (1999) · PubMed · Cited by 48 · see citing works
Physical fitness;: The pathway to healthful living
Hockey, R. V. (1970) · Medical Entomology and Zoology · Cited by 46 · see citing works
Psychotropic drug induced weight gain: mechanisms and management.
Bernstein, J. G. (1988) · PubMed · Cited by 42 · see citing works
Correlates of weight loss in treatment and at follow-up.
Hoiberg, A., Berard, S., WATTEN, R. H., & Caine, C. (1984) · PubMed · Cited by 26 · see citing works
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A systematic review and meta-analysis of exercise interventions in schizophrenia patients
Firth, J., Cotter, J., Elliott, R., French, P., & Yung, A. R. (2015) · Psychological Medicine · doi:10.1017/s0033291714003110 · Cited by 600 · see citing works
Firth, J., Rosenbaum, S., Stubbs, B., Gorczynski, P., Yung, A. R., & Vancampfort, D. (2016) · Psychological Medicine · doi:10.1017/s0033291716001732 · Cited by 577 · see citing works
Compton, M. T., Daumit, G. L., & Druss, B. G. (2006) · Harvard Review of Psychiatry · doi:10.1080/10673220600889256 · Cited by 177 · see citing works
Vancampfort, D., De Hert, M., Skjerven, L. H., Gyllensten, A. L., Parker, A., Mulders, N., Nyboe, L., Spencer, F., & Probst, M. (2012) · Disability and Rehabilitation · doi:10.3109/09638288.2011.587090 · Cited by 127 · see citing works
Svatkova, A., Mandl, R. C. W., Scheewe, T. W., Cahn, W., Kahn, R. S., & Hulshoff Pol, H. E. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv033 · Cited by 120 · see citing works
The pro‐cognitive mechanisms of physical exercise in people with schizophrenia
Firth, J., Cotter, J., Carney, R., & Yung, A. R. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13772 · Cited by 79 · see citing works
Gross, J., Vancampfort, D., Stubbs, B., Gorczynski, P., & Soundy, A. (2016) · Disability and Rehabilitation · doi:10.3109/09638288.2015.1024343 · Cited by 45 · see citing works
- Authors
- Archie, S., Wilson, J. H., Osborne, S., Hobbs, H., & McNiven, J.
- Affiliations
- Hamilton Health Sciences (CA)
- Corresponding author
- Archie, Suzanne
- ORCID
- Archie, Suzanne
- Venue
- The Canadian Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 48
- Issue
- 9
- Pages
- 628-632
- ISSN
- 0706-7437 (ISSN-L)
- 1497-0015
- OpenAlex
- W2115030443
- Cited by
- 121
- References
- 16
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 5
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Canadian Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- schizophrenia, schizoaffective disorder, olanzapine, exercise adherence, YMCA, antipsychotic-induced weight gain, exercise motivation, lifestyle intervention, adjunctive therapy, weight loss
- MeSH terms
- Olanzapine, Adolescent, Adult, Benzodiazepines, Female, Health Services Accessibility, Humans, Male, Middle Aged, Motivation, Physical Fitness, Pilot Projects, Pirenzepine, Prospective Studies, Psychotic Disorders, Random Allocation, Schizophrenia, Antipsychotic Agents, Exercise, Fitness Centers
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