Associations Between Alzheimer’s Disease and Related Dementias and Depressive Symptoms of Partner Caregivers
Open accessAbstract
Family members—mainly spouses and partners—are the primary caregivers for individuals with Alzheimer’s disease and related dementias (ADRDs), chronic progressive illnesses requiring increasing levels of care. We performed a retrospective observational analysis comparing depressive symptoms of 16,650 older individuals with partners without ADRDs, and those recently (within 2 years) or less recently diagnosed (≥2 years prior), controlling for lagged sociodemographic and health characteristics. The mean number of reported depressive symptoms was 1.2 ( SD = 1.8). Compared with respondents with partners with no ADRD, having a partner with any ADRD was associated with a 0.35 increase (95% confidence interval [CI] = [0.30, 0.41]), or 30% increase, in depressive symptoms. A less recent partner diagnosis was associated with a 33% increase, while a recent diagnosis was associated with a 27% increase. Clinically meaningful and longitudinally worsening depressive symptoms amplify the need to prioritize partner health and family-centered care following an ADRD diagnosis.
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Caring for a spouse with dementia is associated with a 30% increase in depressive symptoms compared with spousal caregivers of partners without dementia.
“Caring for a spouse with dementia is associated with a 30% increase in depressive symptoms compared with spousal caregivers of partners without dementia. 529”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [529]
The Abstract and Adjusted Results report a 30% increase in depressive symptoms among respondents whose partners had ADRD compared with respondents whose partners did not. However, the Methods > Study Population section calls the latter group respondents, not spousal caregivers; it does not establish that they provided care. (LLM, conf=0.88)
Experimental — accuracy not yet measuredCaring for a spouse with dementia is associated with a 30% increase in depressive symptoms compared with spousal caregivers of partners without dementia.
“Caring for a spouse with dementia is associated with a 30% increase in depressive symptoms compared with spousal caregivers of partners without dementia.484”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [484]
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- Authors
- Harris, M. L., Titler, M. G., & Hoffman, G. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Harris, Melissa L.
- Venue
- Journal of Applied Gerontology
- Publisher
- SAGE Publications
- Published
- 2020-08-29
- Volume
- 40
- Issue
- 7
- Pages
- 772-780
- ISSN
- 0733-4648 (ISSN-L)
- 1552-4523
- PMC
- PMC7914256
- OpenAlex
- W3081565223
- Cited by
- 33
- References
- 52
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 3 · 2022: 3 · 2021: 3
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Gerontology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Nursing Research (Predoctoral Fellowship Training Grant (2018-Curren)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Health Professions › Pharmacy › Nursing care and research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- Alzheimer's disease and related dementias, depressive symptoms, partner caregivers, caregiver burden, spouses, family caregivers, family-centered care, older adults
- MeSH terms
- Alzheimer Disease, Depression, Humans, Retrospective Studies, Caregivers, Spouses
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