The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Clinical Aspects of Human Circadian Rhythms
Abstract
Circadian rhythmicity can be important in the pathophysiology, diagnosis, and treatment of clinical disease. Due to the difficulties in conducting the necessary experimental work, it remains unknown whether approximately 24-h changes in pathophysiology or symptoms of many diseases are causally linked to endogenous circadian rhythms or to other diurnal factors that change across the day, such as changes in posture, activity, sleep or wake state, or metabolic changes associated with feeding or fasting. Until the physiology is accurately known, appropriate treatment cannot be designed. This review includes an overview of clinical disorders that are caused or affected by circadian or diurnal rhythms. The clinical side effects of disruption of circadian rhythmicity, such as in shiftwork, including the public health implications of the disrupted alertness and performance, are also discussed.
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“The misalignment of the circadian rhythm with the 24 h outside environment may lead to a circadian rhythm disorder which negatively affects sleep and may lead to health conditions including metabolic, cognitive, cardiovascular, and gastrointestinal impairments [15].”
From The Cyclical Battle of Insomnia and Mental Health Impairment in Firefighters: A Narrative Review (2024) · cites this paper as [15]
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Cited by
Sorted by citations
Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087
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Metadata
- Authors
- Klerman, E. B.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Klerman, Elizabeth B.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2005-08
- Volume
- 20
- Issue
- 4
- Pages
- 375-386
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2130935086
- Cited by
- 139
- References
- 114
- Citations by year
- 2025: 5 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 15 · 2013: 4 · 2012: 6
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration
- Deutsches Krebsforschungszentrum
- National Space Biomedical Research Institute
- National Institutes of Health
- National Institute on Aging (P01AG009975, P01-AG09775)
- National Center for Research Resources (M01 RR 02635, M01RR002635)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD040291, R01-HD40291, K02HD045459)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythm, diurnal cycle, circadian rhythm disorders, shift work, circadian rhythm disruption, alertness, employee performance, sleep-wake states, fasting and feeding, circadian medicine
- MeSH terms
- Biological Clocks, Circadian Rhythm, Disease, Humans, Sleep, Wakefulness, Work Schedule Tolerance, Chronobiology Disorders
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