The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback
Abstract
This mini-review article presents the remarkable progress that has been made in the past decade in our understanding of the neural circuitry underlying the regulation of sleep-wake states and circadian control of behaviors. Following a brief introduction to sleep architecture and physiology, the authors describe the neural circuitry and neurotransmitters that regulate sleep and cortical arousal (i.e., wakefulness). They next examine how sleep and wakefulness are regulated by mutual inhibition between sleep-and arousal-promoting circuitry and how this interaction functions analogously to an electronic “flip-flop” switch that ensures behavioral state stability. The authors then discuss the role of circadian and homeostatic processes in the consolidation of sleep, including the physiologic basis of homeostatic sleep drive (i.e., wake-dependent increase in sleep propensity) and the role of the SCN in the circadian regulation of sleep-wake cycles. Finally, they describe the hypothalamic circuitry for the integration of photic and nonphotic environmental time cues and how this integration allows organisms to sculpt patterns of rest-activity and sleep-wake cycles that are optimally adaptive.
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Citations
Cites
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Narcolepsy in orexin Knockout Mice
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Self-citationHypothalamic regulation of sleep and circadian rhythms
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Self-citationDamiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Neurocognitive consequences of sleep deprivation
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Self-citationNeurocognitive Consequences of Sleep Deprivation
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Cited by
Altena, E., Baglioni, C., Espie, C. A., Ellis, J., Gavriloff, D., Holzinger, B., Schlarb, A., Frase, L., Jernelöv, S., & Riemann, D. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13052 · Cited by 991
Melatonin—A pleiotropic, orchestrating regulator molecule
Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843
Sleep disturbance as transdiagnostic: Consideration of neurobiological mechanisms
Harvey, A. G., Murray, G., Chandler, R. A., & Soehner, A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.003 · Cited by 609
Reassessment of the structural basis of the ascending arousal system
Fuller, P., Sherman, D., Pedersen, N. P., Saper, C. B., & Lu, J. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22559 · Cited by 465
Self-citationSleep deprivation, vigilant attention, and brain function: a review
Hudson, A. N., Van Dongen, H. P. A., & Honn, K. A. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0432-6 · Cited by 363
Metadata
- Authors
- Fuller, P. M., Gooley, J. J., & Saper, C. B.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2006-12
- Volume
- 21
- Issue
- 6
- Pages
- 482-493
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2019685634
- Cited by
- 577
- References
- 81
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006). Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback. Journal of Biological Rhythms. https://doi.org/10.1177/0748730406294627
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
