Human Diurnal Preference and Circadian Rhythmicity Are Not Associated with the CLOCK 3111C/T Gene Polymorphism
Open accessAbstract
Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker.
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Healthy adults show interindividual differences in the free-running circadian period (tau), which shows robust stability within individuals.
“Healthy adults show interindividual differences in the free-running circadian period (tau),94–98 which shows robust stability within individuals.97”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [98]
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- Authors
- Chang, A.-M., Buch, A. M., Bradstreet, D. S., Klements, D. J., & Duffy, J. F.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Chang, Anne-Marie
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2011-05-31
- Volume
- 26
- Issue
- 3
- Pages
- 276-279
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- PMC
- PMC3689429
- OpenAlex
- W2064736468
- Cited by
- 37
- References
- 11
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 10 · 2012: 5
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brigham and Women's Hospital (M01 RR02635)
- Harvard Catalyst (UL1-RR025758, RR025758)
- National Space Biomedical Research Institute (HFP01601)
- National Institutes of Health
- National Institute on Aging (R01AG006072, AG09975, AG06072, P01AG009975)
- National Heart, Lung, and Blood Institute (HL077453, R01HL080978, F32HL078360, HL077399, R01HL077399, HL080978, HL078360, R01HL077453)
- National Institute of Mental Health (MH045130, R01MH045130)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK089378)
- National Institute of Neurological Disorders and Stroke (NS041886, R01NS041886, NS054277, R01NS054277)
- National Center for Research Resources (M01 RR 02635, UL1RR025758, M01RR002635)
- National Center for Complementary and Integrative Health (AT002571, R21AT002571)
- Air Force Office of Scientific Research (FA9550-)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- clock genes, diurnal preference, chronotype, circadian rhythm, circadian period, sleep timing, genetic association
- MeSH terms
- Adolescent, Adult, Aged, Circadian Rhythm, Female, Humans, Male, Melatonin, Middle Aged, Prospective Studies, Sleep, Polymorphism, Single Nucleotide, Young Adult, CLOCK Proteins
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