The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Aging Alters Circadian Rhythms in the Mouse Eye
Open accessAbstract
The eye contains a circadian system that acts independently from the master circadian clock located in the brain. This circadian system regulates important physiological functions within the eye. Emerging experimental evidence also indicates that disruption of the ocular circadian clock, or its outputs, negatively affects the overall health of the eye. Although previous studies have investigated the effect of aging on the regulation of circadian rhythms, no study has investigated the effects of aging on the circadian rhythm in the ocular system. The aim of the present study was to investigate how aging affects the circadian rhythm of PER2::LUC bioluminescence in the retina, retinal pigment epithelium (RPE), and cornea. Our data suggest that among the 3 different ocular tissues investigated, the retina appears to be the most affected by aging whereas the RPE and cornea are less affected by aging. Our data, along with studies of other organs and tissues, suggest that reduction in the amplitude of rhythms is probably the most severe effect of aging on the circadian clock.
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“A recent study further suggests that the aging of retinal tissue most severely effects the reduction in amplitude of rhythm of the circadian clock 51.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [51]
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Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188
Age-Related Decline in Circadian Output
Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., & Block, G. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0451-11.2011 · Cited by 386 · cited 1×
“Our data agree with previous studies which reported that amplitudes of circadian rhythms in the SCN and other tissues decline during aging (Nakamura et al., 2011; Nakamura et al., 2015; Aujard et al., 2001).”
Effects of aging on central and peripheral mammalian clocks
Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152318499 · Cited by 317 · cited 4×
“In contrast, aging did not affect the phase and period of PER2::LUC rhythm in the mouse cornea, consistent with data from rat corneas (Yamazaki et al., 2002).”
InfluentialCircadian organization of the mammalian retina: From gene regulation to physiology and diseases
McMahon, D. G., Iuvone, P. M., & Tosini, G. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.12.001 · Cited by 203 · cited 2×
“This circadian system regulates important functions such as visual processing, susceptibility to light-induced photoreceptor damage, neurotransmitter synthesis and release, disk shedding and phagocytosis, corneal thickness, and intraocular pressure (see McMahon et al., 2014, for a recent review).”
InfluentialSelf-citationDubrovsky, Y. V., Samsa, W. E., & Kondratov, R. V. (2010) · Aging · doi:10.18632/aging.100241 · Cited by 193 · cited 1×
“Clock mutant mice developed cataracts during aging (Dubrovsky et al., 2010), and Clock/Npas2 KO mice showed a significant reduction in the thickness of the photoreceptor layer (Baba et al.”
Age-Related Changes and Diseases of the Ocular Surface and Cornea
Gipson, I. K. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12840 · Cited by 174
Gossan, N., Zeef, L. A. H., Hensman, J. J., Hughes, A. T. L., Bateman, J. F., Rowley, L., Little, C. B., Piggins, H. D., Rattray, M., Boot-Handford, R., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38035 · Cited by 169 · cited 3×
“A decline in amplitude of the bioluminescence rhythm of xiphoid cartilage explanted from 20- to 24-month-old PER2::LUC mice and intervertebral disk from 12-month-old PER2::LUC mice also showed a damped circadian amplitude (Gossan et al., 2013; Dudek et al., 2017).”
Dudek, M., Yang, N., Ruckshanthi, J. P. D., Williams, J. L., Borysiewicz, E., Wang, P., Adamson, A. D., Li, J., Bateman, J. F., White, M., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209428 · Cited by 167 · cited 1×
“A decline in amplitude of the bioluminescence rhythm of xiphoid cartilage explanted from 20- to 24-month-old PER2::LUC mice and intervertebral disk from 12-month-old PER2::LUC mice also showed a damped circadian amplitude (Gossan et al., 2013; Dudek et al., 2017).”
Sellix, M. T., Evans, J. A., Leise, T., Castañón‐Cervantes, O., Hill, D. D., Delisser, P., Block, G. D., Menaker, M., & Davidson, A. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3559-12.2012 · Cited by 153 · cited 4×
“While this period-phase relationship would not be predicted from classic circadian entrainment theory, it is consistent with previous investigations in the mouse (Nakamura et al., 2015; Yamazaki et al., 2002; Sellix et al., 2012).”
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Research works printed but not linked: 1
- Baba K, 2010, Mol Vis, 16, 2605
Cited by
Sorted by citations
The inner clock-Blue light sets the human rhythm
Wahl, S., Engelhardt, M., Schaupp, P., Lappe, C., & Ivanov, I. V. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900102 · Cited by 293
Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target
Bellezza, I. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01280 · Cited by 180
“The eye contains a circadian system and aging affects the circadian rhythm of the retina (Baba and Tosini, 2018).”
Interplay between aging and other factors of the pathogenesis of age-related macular degeneration
Błasiak, J., Sobczuk, P., Pawłowska, E., & Kaarniranta, K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101735 · Cited by 86
Gubin, D. G., Neroev, V. V., Malishevskaya, Т. N., Cornélissen, G., Astakhov, S., Kolomeichuk, S. N., Yuzhakova, N., Kabitskaya, Y., & Weinert, D. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12730 · Cited by 79
Lax, P., Ortuño‐Lizarán, I., Maneu, V., Vidal‐Sanz, M., & Cuenca, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133164 · Cited by 68
Metadata
- Authors
- Baba, K., & Tosini, G.
- Affiliations
- Morehouse School of Medicine (US)
- Corresponding author
- Tosini, Gianluca
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2018-06-25
- Volume
- 33
- Issue
- 4
- Pages
- 441-445
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- PMC
- PMC6398161
- OpenAlex
- W2811137840
- Cited by
- 35
- References
- 28
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 10 · 2018: 2
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS083932)
- National Eye Institute (EY022216, EY026291)
- National Institute of General Medical Sciences (GM116760)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- aging, circadian rhythm, retina, retinal pigment epithelium, cornea, ocular aging
- MeSH terms
- Aging, Animals, Circadian Rhythm, Cornea, Luminescent Measurements, Retina, Mice, Retinal Pigment Epithelium, Period Circadian Proteins, Circadian Clocks
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