Cited by 386Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

Age-Related Decline in Circadian Output

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Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., Block, G. D.·2011·Journal of Neuroscience

Abstract

Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and fragmentation of the sleep episodes, are commonly associated with aging in humans and other mammals. While there are undoubtedly many factors contributing to these changes, a body of literature is emerging, suggesting that an age-related decline in the central circadian clock in the suprachiasmatic nucleus (SCN) may be a key element responsible. To explore age-related changes in the SCN, we have performed in vivo multiunit neural activity (MUA) recordings from the SCN of freely moving young (3-5 months) and middle-aged (13-18 months) mice. Importantly, the amplitude of day-night difference in MUA was significantly reduced in the older mice. We also found that the neural activity rhythms are clearly degraded in the subparaventricular zone, one of the main neural outputs of the SCN. Surprisingly, parallel studies indicate that the molecular clockwork in the SCN as measured by PER2 exhibited only minor deficits at this same age. Thus, the circadian output measured at the level of neural activity rhythms in the SCN is degraded by aging, and this decline occurs before the disruption of key components of the molecular clockwork.

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Crossref · 10.1523/jneurosci.0451-11.2011

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  • These SCN network changes result in desynchronization and a reduction in the amplitude of neuronal activity rhythms and, ultimately, physiological and behavioural rhythms.

    “These SCN network changes result in desynchronization and a reduction in the amplitude of neuronal activity rhythms248,249 and, ultimately, physiological and behavioural rhythms241.”

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Authors
Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., & Block, G. D.
Affiliations
  • University of California, Los Angeles (US)
  • The University of Osaka (JP)
  • Vanderbilt University (US)
Corresponding author
Colwell, C. S.
Venue
Journal of Neuroscience
Published
2011-07-13
Volume
31
Issue
28
Pages
10201-10205
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2094874423
Cited by
386
References
35
Citations by year
2026: 17 · 2025: 27 · 2024: 27 · 2023: 33 · 2022: 25 · 2021: 34 · 2020: 36 · 2019: 31 · 2018: 19 · 2017: 24 · 2016: 21 · 2015: 28 · 2014: 14 · 2013: 23 · 2012: 26
FWCI
9.46
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • CHDI Foundation
  • National Institutes of Health (AG028748)
  • Japan Society for the Promotion of Science (23659871)
  • National Institute on Aging (P30AG028748)
  • National Institute of Mental Health (R01MH062517)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
suprachiasmatic nucleus, sleep-wake cycle, Per2, sleep fragmentation, mice
MeSH terms
Aging, Animals, Biological Clocks, Circadian Rhythm, Electrodes, Implanted, Electrophysiology, Male, Motor Activity, Suprachiasmatic Nucleus, Mice, Period Circadian Proteins

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