Daily Variations in Pineal Melatonin Concentrations in Inbred and Outbred Mice
Open accessAbstract
Melatonin was measured using a specific radioimmunoassay in 1 strain of outbred mice (OF1 Swiss) and 4 strains of inbred mice, 2 of them being known to synthesize melatonin (CBA and C3H) and the 2 others being controversial (BALB/c and C57BL/6). In this study, the 5 mouse strains were able to synthesize melatonin, but the basal levels as well as the diurnal variations were very different from one strain to another. CBA and C3H strains showed a clear-cut day-night rhythm of pineal melatonin concentration, with peak levels of 276 ± 22 pg/pineal in CBA and 135 ± 12 pg/pineal in C3H. In BALB/c, the authors confirmed the presence of a very short melatonin peak (15 min) in the middle of the dark period. In C57BL/6 and OF1 Swiss, a very small but significant peak was observed in the middle of the darkness. In the former, another small peak was also observed at light onset. Whether these very small peaks, which may be related to the deficience of N-acetyl transferase activity reported by others, have a physiological meaning remains to be determined.
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BALB/c mice have markedly attenuated melatonin production.
“In the present study, we used BALB/c mice that have markedly attenuated melatonin production26, 27 to eliminate any effects of circadian disruption resulting from dysregulated melatonin.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [26]
Circadian disruption can negatively affect development independently of alterations in melatonin.
“suggesting that circadian disruption can negatively affect development independently of alterations in this hormone26, 27.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [26]
Use of BALB/c mice minimizes the role of melatonin in all groups.
“In the present study, use of BALB/c mice minimizes the role of melatonin in all groups”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [26]
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Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740 · see citing works
Melatonin in mice: rhythms, response to light, adrenergic stimulation, and metabolism
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Smarr, B. L., Grant, A. D., Perez, L., Zucker, I., & Kriegsfeld, L. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03406-4 · Cited by 86 · see citing works
- Authors
- Vivien-Roels, B., Malan, A., Rettori, M.-C., Delagrange, P., Jeanniot, J.-P., & Pévet, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut de Recherches Internationales Servier (France) (FR)
- Servier (France) (FR)
- Technologie SERVIER, Orléans, France
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 1998-10
- Volume
- 13
- Issue
- 5
- Pages
- 403-409
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2051855123
- Cited by
- 129
- References
- 12
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 11 · 2013: 4 · 2012: 7
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Recherche Agronomique
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- melatonin, pineal gland, diurnal variation, circadian rhythm, inbred mouse strains, melatonin synthesis, CBA mice, C3H mice, BALB/c mice, C57BL/6 mice
- MeSH terms
- Animals, Circadian Rhythm, Female, Male, Gas Chromatography-Mass Spectrometry, Melatonin, Mice, Inbred Strains, Osmolar Concentration, Pineal Gland, Mice
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