Regional Microstructural and Volumetric Magnetic Resonance Imaging (MRI) Abnormalities in the Corpus Callosum of Neonates With Congenital Heart Defect Undergoing Cardiac Surgery
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The purpose of the study is to investigate the structural development of the corpus callosum in term neonates with congenital heart defect before and after surgery using diffusion tensor imaging and 3-dimensional T1-weighted magnetic resonance imaging (MRI). We compared parallel and radial diffusions, apparent diffusion coefficient (ADC), fractional anisotropy, and volume of 5 substructures of the corpus callosum: genu, rostral body, body, isthmus, and splenium. Compared to healthy controls, we found a significantly lower volume of the splenium and total corpus callosum and a higher radial diffusion and lower fractional anisotropy in the splenium of patients presurgery; a lower volume in all substructures in the postsurgery group; higher radial diffusion in the rostral body, body, and splenium; and a higher apparent diffusion coefficient in the splenium of postsurgery patients. Similar fractional anisotropy changes in congenital heart defect patients were reported in preterm infants. Our findings in apparent diffusion coefficient in the splenium of these patients (pre and postsurgery) are comparable to findings in preterm neonates with psychomotor delay. Delayed maturation of the isthmus was also reported in preterm infants.
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Fractional anisotropy values in the corpus callosum are decreased in neonates with transposition of the great arteries before and after cardiac surgery.
“Fractional anisotropy values in the corpus callosum are decreased in neonates with TGA before and after cardiac surgery.54,56”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [56]
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Intraoperative sodium range affects white matter microstructure in neonatal congenital heart diseasePreprint
van der Meijden, M. E. M., van Loon, K., Nijman, M., Talacua, H., Breur, J. M. P. J., Nijman, J., Claessens, N. H. P., Counsell, S. J., Benders, M. J. N. L., & Bonthrone, A. F. (2025) · medRxiv · doi:10.1101/2025.10.16.25338157
Intraoperative sodium range affects white matter microstructure in neonatal congenital heart disease
van der Meijden, M. E. M., van Loon, K., Nijman, M., Talacua, H., Breur, J. M. P. J., Nijman, J., Claessens, N. H. P., Counsell, S. J., Benders, M. J. N. L., & Bonthrone, A. F. (2026) · International Journal of Cardiology Congenital Heart Disease · doi:10.1016/j.ijcchd.2026.100666
“Diffusion-weighted magnetic resonance imaging (dMRI) studies have shown pre-and postoperative white matter (WM) microstructural alterations in neonates with CHD, including high mean diffusivity (MD) and low fractional anisotropy (FA) compared to heart-healthy neonates [7 – 9].”
Neonatal Cerebrovascular Stability Index and Oxygenation With 3-Month Neurodevelopmental Outcomes
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Dogan, Y. E., Vargas-Boggiano, D., Bleiweis, M. S., Philip, J., Narasimhulu, S. S., Tuna, İ. S., & Weiss, M. D. (2026) · Pediatric Research · doi:10.1038/s41390-026-05454-x
- Authors
- Hagmann, C., Singer, J., Latal, B., Knirsch, W., & Makki, M.
- Affiliations
- University Hospital Zurich (CH)
- University Children's Hospital Zurich (CH)
- Corresponding author
- Makki, Malek
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2015-06-30
- Volume
- 31
- Issue
- 3
- Pages
- 300-308
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W825636494
- Cited by
- 27
- References
- 37
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 3 · 2017: 2 · 2016: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-09-08)
- Open access
- green
- doi.org
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- corpus callosum, congenital heart disease, neonates, cardiac surgery, splenium, fractional anisotropy, apparent diffusion coefficient, radial diffusion, corpus callosum volume, diffusion tensor imaging
- MeSH terms
- Corpus Callosum, Female, Heart Defects, Congenital, Humans, Image Processing, Computer-Assisted, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging, Male, Organ Size, Postoperative Period, Treatment Outcome, Diffusion Tensor Imaging, Preoperative Period
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