Neurodevelopmental outcome, psychological adjustment, and quality of life in adolescents with congenital heart disease
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Aim: The aim of this study was to examine neurodevelopment, psychological adjustment, and health‐related quality of life (HRQ oL) in adolescents after bypass surgery for congenital heart disease (CHD) during early childhood. Method: Fifty‐nine adolescents (34 females, 25 males) with CHD were examined at a median age of 13 years 8 months (range 11y 5mo–16y 11mo). Outcome was assessed with the W echsler I ntelligence S cale for C hildren, (fourth edition); the B eery Test of V isual‐M otor I ntegration; the R ey–O sterrieth C omplex F igure T est; the Z urich N euromotor A ssessment; the S trengths and D ifficulties Q uestionnaire; and the KIDSCREEN questionnaires. Results were compared with those of 40 age‐ and sex‐matched healthy comparison individuals. Results: Outcome with regard to full‐scale IQ, perceptual reasoning, and the working memory scale was poorer in patients with CHD than in the comparison group (all p≤0.001). Visual perception, visuomotor integration (p≤0.001), and executive functions (Rey figure copy: p=0.05) were also affected. Patients with CHD also had lower scores on all motor domains (p<0.02) except static balance. Psychological adjustment was affected only in the ‘peer relationship’ domain (p=0.05). Quality of life was similar to that of typically developing peers. Interpretation: Adolescents with CHD may manifest persistent cognitive and motor impairments, while psychological adjustment and self‐reported HRQ oL are mostly typical. Thus, long‐term neurodevelopmental evaluations are necessary to provide early educational and therapeutic support.
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Adolescents with congenital heart disease have lower IQs and reduced executive functioning, shown by poorer perceptual reasoning and working memory than typically developing peers.
“In adolescence, young people with CHD continue to show lower IQs, and reduced executive functioning can be recognized by the poorer perceptual reasoning and working memory scores in adolescents with CHD than their peers with typical development.[17][18][19]”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [17]
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Self-citation
- Authors
- Schaefer, C., von Rhein, M., Knirsch, W., Huber, R., Natalucci, G., Caflisch, J., Landolt, M. A., & Latal, B.
- Affiliations
- University Children's Hospital Zurich (CH)
- Child Development Centre University Children's Hospital Zurich Zurich Switzerland
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 2013-08-13
- Volume
- 55
- Issue
- 12
- Pages
- 1143-1149
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W2011665243
- Cited by
- 160
- References
- 28
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 13 · 2023: 13 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 21 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 13 · 2014: 6 · 2013: 3
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schweizerische Herzstiftung
- Universitätsspital Zürich
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- congenital heart disease, neurodevelopmental outcomes, psychological adjustment, health-related quality of life, adolescents, cardiac surgery, cognitive impairment, visual-motor integration, executive function, motor impairment, peer relationships, long-term follow-up
- MeSH terms
- Adaptation, Psychological, Adolescent, Child, Developmental Disabilities, Cognition Disorders, Concept Formation, Female, Heart Defects, Congenital, Humans, Male, Memory, Short-Term, Neuropsychological Tests, Quality of Life, Surveys and Questionnaires, Wechsler Scales, Outcome Assessment, Health Care, Executive Function
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