Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery
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BACKGROUND AND PURPOSE: Neonates with severe CHD require CPB within the first days of life. White matter injury can occur before surgery, and this may impair the long-term neurodevelopmental and psychosocial outcome. The purpose of this study was to assess the microstructural development of the CC in infants with CHD before and after CPB for transposition of the great arteries. MATERIALS AND METHODS: Fifteen patients with CHD and 11 age-matched HC were recruited. We separately quantified the parallel (E1) and perpendicular (E23) diffusions, the ADC, and FA of the genu of the CC and splenium of the CC before and after surgery. RESULTS: In presurgical measures of the genu of the CC, higher E23 (P = .018), higher ADC (P = .026), and lower FA (P = .033) values were measured compared with those in HC. In the postsurgery scans, the genu of the CC had higher E23 (P = .013), higher ADC (P = .012), and lower FA (P = .033) values compared with those in HC. There was no significant difference in any DTI indices between the pre- and postsurgical groups. CONCLUSIONS: We report abnormal microstructural development in the genu of the CC of infants with d-TGA before and after CPB. High E23, high ADC, and low FA values in the genu of the CC may be explained by abnormal axonal pruning, thinner myelin sheaths, smaller axonal diameters, or more oligodendrocytes. It appears that the genu of the CC is more vulnerable than the splenium of the CC in patients with CHD and may serve as a biomarker to identify infants at highest risk for adverse neurodevelopmental outcome.
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Fractional anisotropy values in the corpus callosum are decreased in neonates with transposition of the great arteries before and after cardiac surgery.
“Fractional anisotropy values in the corpus callosum are decreased in neonates with TGA before and after cardiac surgery.54,56”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [54]
This finding of lower fractional anisotropy in congenital heart disease has been replicated by several other studies over the last decade.
“This finding has been replicated over the last decade by several other studies.[53][54][55]”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [54]
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“Fractional anisotropy values in the corpus callosum are decreased in neonates with TGA before and after cardiac surgery.(54,56) Studies in the preterm population have shown that decreased fractional anisotropy values in the corpus callosum are associated with impaired cognitive functioning at pre-school age in infants…”
BackgroundNeurodevelopmental outcome in children with congenital heart disease
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“Median (range) days to first MRI 6 (1-10) 22 (13-32)”
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- Authors
- Makki, M., Scheer, I., Hagmann, C., Liamlahi, R., Knirsch, W., Dave, H., Bernet, V., Batinic, K., & Latal, B.
- Affiliations
- University Children's Hospital Zurich (CH)
- University Hospital Zurich (CH)
- Venue
- American Journal of Neuroradiology
- Published
- 2012-10-04
- Volume
- 34
- Issue
- 3
- Pages
- 634-640
- ISSN
- 0195-6108 (ISSN-L)
- 1936-959X
- PMC
- PMC7964918
- OpenAlex
- W2152762885
- Cited by
- 10
- References
- 34
- Citations by year
- 2020: 1 · 2019: 2 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- American Journal of Neuroradiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- d-transposition of the great arteries, congenital heart disease, cardiopulmonary bypass, neonates, corpus callosum, splenium of corpus callosum, white matter microstructure, diffusion tensor imaging, axonal pruning, myelination, neurodevelopmental outcomes
- MeSH terms
- Abnormalities, Multiple, Cardiopulmonary Bypass, Female, Humans, Infant, Newborn, Male, Nerve Fibers, Myelinated, Sensitivity and Specificity, Transposition of Great Vessels, Reproducibility of Results, Diffusion Tensor Imaging, Agenesis of Corpus Callosum, Connectome
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