Heavy Metal in the Intensive Care Unit: A Review of Current Literature on Trace Element Supplementation in Critically Ill Patients
Abstract
Trace elements are essential for many physiologic processes. In recent years, supplementation has been studied for a variety of indications, including glycemic control, wound healing, antioxidant effect, and anemia. Critical illness, especially states such as burns, traumas, and septic shock, is associated with inflammatory and oxidative stress, immune dysfunction, and malnutrition. In these patients, enteral and parenteral nutrition or pharmaceutical supplementation is used to provide essential macronutrients, including trace elements. The purpose of this review is to describe trace element supplementation, including iron, copper, chromium, manganese, selenium, and zinc, and highlight their mechanism, pharmacology, outcome data, and adverse effects.
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Total parenteral nutrition may neglect a sufficient supply with iron, folic acid and cobalamin for erythropoiesis.
“Furthermore, total parenteral nutrition may neglect a sufficient supply with iron, folic acid and cobalamin for erythropoiesis (Rech et al., 2013).”
From Iron in infection and immunity (2020) · cites this paper as Rech et al., 2013
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- Authors
- Rech, M., To, L., Tovbin, A., Smoot, T., & Mlynarek, M.
- Affiliations
- Loyola University Medical Center (US)
- Henry Ford Hospital (US)
- Corresponding author
- Rech, Megan
- Venue
- Nutrition in Clinical Practice
- Publisher
- Wiley
- Published
- 2013-12-12
- Volume
- 29
- Issue
- 1
- Pages
- 78-89
- ISSN
- 0884-5336 (ISSN-L)
- 1941-2452
- OpenAlex
- W2110679136
- Cited by
- 50
- References
- 93
- Citations by year
- 2025: 4 · 2024: 5 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nutrition in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- trace element supplementation, intensive care, critical illness, iron, copper, chromium, manganese, selenium, zinc, oxidative stress, inflammatory stress, enteral nutrition, parenteral nutrition, malnutrition, septic shock, burns, trauma (physical injury), anemia, wound healing, glycemic control
- MeSH terms
- Antioxidants, Chromium, Copper, Humans, Intensive Care Units, Iron, Manganese, Nutritional Requirements, Parenteral Nutrition, Selenium, Wound Healing, Zinc, Randomized Controlled Trials as Topic, Critical Illness, Dietary Supplements
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