Cited by 50Trace Elements in HealthClinical Nutrition and GastroenterologyIron Metabolism and Disorders

Heavy Metal in the Intensive Care Unit: A Review of Current Literature on Trace Element Supplementation in Critically Ill Patients

Rech, Megan, To, Long, Tovbin, Alina, Smoot, Thomas, Mlynarek, Mark·2014·Nutrition in Clinical Practice

Abstract

Trace elements are essential for many physiologic processes. In recent years, supplementation has been studied for a variety of indications, including glycemic control, wound healing, antioxidant effect, and anemia. Critical illness, especially states such as burns, traumas, and septic shock, is associated with inflammatory and oxidative stress, immune dysfunction, and malnutrition. In these patients, enteral and parenteral nutrition or pharmaceutical supplementation is used to provide essential macronutrients, including trace elements. The purpose of this review is to describe trace element supplementation, including iron, copper, chromium, manganese, selenium, and zinc, and highlight their mechanism, pharmacology, outcome data, and adverse effects.

Integrity signals

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Crossref · 10.1177/0884533613515724

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93 of 93 references verified0 citation errors · 0 not checkable

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  • Total parenteral nutrition may neglect a sufficient supply with iron, folic acid and cobalamin for erythropoiesis.

    “Furthermore, total parenteral nutrition may neglect a sufficient supply with iron, folic acid and cobalamin for erythropoiesis (Rech et al., 2013).”

    From Iron in infection and immunity (2020) · cites this paper as Rech et al., 2013

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Authors
Rech, M., To, L., Tovbin, A., Smoot, T., & Mlynarek, M.
Affiliations
  • Loyola University Medical Center (US)
  • Henry Ford Hospital (US)
Corresponding author
Rech, Megan
Venue
Nutrition in Clinical Practice
Publisher
Wiley
Published
2013-12-12
Volume
29
Issue
1
Pages
78-89
ISSN
  • 0884-5336 (ISSN-L)
  • 1941-2452
OpenAlex
W2110679136
Cited by
50
References
93
Citations by year
2025: 4 · 2024: 5 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 3
FWCI
0.53
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition in Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
trace element supplementation, intensive care, critical illness, iron, copper, chromium, manganese, selenium, zinc, oxidative stress, inflammatory stress, enteral nutrition, parenteral nutrition, malnutrition, septic shock, burns, trauma (physical injury), anemia, wound healing, glycemic control
MeSH terms
Antioxidants, Chromium, Copper, Humans, Intensive Care Units, Iron, Manganese, Nutritional Requirements, Parenteral Nutrition, Selenium, Wound Healing, Zinc, Randomized Controlled Trials as Topic, Critical Illness, Dietary Supplements

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