The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Encapsulation of Curcumin in Pluronic Block Copolymer Micelles for Drug Delivery Applications
Abstract
We report here the potential of Pluronic tri-block copolymer micelles for the formulation of curcumin, a natural dietary compound having great therapeutic potential against many diseases including cancer. Two most commonly used Pluronic F127 and F68 were used for the formulation and analyzed for curcumin encapsulation efficiency and stability. The encapsulation of drug in micelle was highly dependent on drug-to-copolymer ratio. Pluronic F127 showed better encapsulation efficiency than Pluronic F68. In vitro release profile demonstrated slower and sustained release of curcumin from Pluronic micelles. The lyophilized form of the formulations exhibited good stability for long-term storage. The physical interaction of curcumin with Pluronic was evident by XRD analysis, UV-visible, fluorescence, and FT-IR spectroscopy. AFM study showed that the drug-encapsulated micelles were spherical in shape with diameters below 100 nm. The in vitro cytotoxicity of the drug formulations was investigated with HeLa cancer cells. Pluronic-encapsulated curcumin showed comparable anticancer activity with free curcumin.
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Citations
Cites
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · cited 1×
“Curcumin also undergoes rapid degradation by enzymes in the intestinal tract, resulting in low oral bioavailability [6].”
BackgroundMaeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495
Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00009-3 · Cited by 1,474
Danson, S., Ferry, D., Alakhov, V, Margison, J., Kerr, D., Jowle, D., Brampton, M., Halbert, G., & Ranson, M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601856 · Cited by 382
Kabanov, A. V., Chekhonin, V. P., Alakhov, V. Y., Batrakova, E. V., Lebedev, A. S., Melik-Nubarov, N. S., Arzhakov, S. A., Levashov, A. V., Morozov, G. V., Severin, E. S., et al. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81689-8 · Cited by 296
Cited by
Enhanced Dispersibility and Bioactivity of Curcumin by Encapsulation in Casein Nanocapsules
Pan, K., Zhong, Q., & Baek, S. J. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400752a · Cited by 441
Metadata
- Authors
- Sahu, A., Kasoju, N., Goswami, P., & Bora, U.
- Venue
- Journal of Biomaterials Applications
- Publisher
- SAGE Publications
- Published
- 2010-03-05
- Volume
- 25
- Issue
- 6
- Pages
- 619-639
- ISSN
- 0885-3282 (ISSN-L)
- 1530-8022
- OpenAlex
- W2060440900
- Cited by
- 256
- References
- 5
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sahu, A., Kasoju, N., Goswami, P., & Bora, U. (2011). Encapsulation of Curcumin in Pluronic Block Copolymer Micelles for Drug Delivery Applications. Journal of Biomaterials Applications. https://doi.org/10.1177/0885328209357110
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