The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications
Abstract
The purpose of the present study was to fabricate polymeric nanoparticles as drug carriers for encapsulated curcumin with enhanced anti-colorectal cancer applications. Nanoparticles were formulated from chitosan and gum arabic, natural polysaccharides, via an emulsification solvent diffusion method. The formation of curcumin nanoparticles was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimeter. The results show that curcumin was entrapped in carriers with +48 mV, 136 nm size, and high encapsulation efficiency (95%). Based on an in vitro release study, we inferred that curcumin nanoparticles could tolerate hydrolysis due to gastric juice or small intestinal enzymes, and therefore, it should reach the colon largely intact. In addition, curcumin nanoparticles had higher anti-colorectal cancer properties than free curcumin due to greater cellular uptake. Therefore, we concluded that curcumin was successfully encapsulated in chitosan-gum arabic nanoparticles with superior anti-colorectal cancer activity.
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“10.1016/j.bcp.2009.09.003”
Cited work 10.1016/j.bcp.2009.09.003 · retracted 2016-02-15 · notice 10.1016/j.bcp.2015.11.008 · this paper published 2015-07-13
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Cited by
Sorted by citations
Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges
Elmowafy, M., Shalaby, K., Elkomy, M. H., Alsaidan, O. A., Gomaa, H. A. M., Abdelgawad, M. A., & Mostafa, E. M. (2023) · Polymers · doi:10.3390/polym15051123 · Cited by 373
Curcumin Nanoformulations for Colorectal Cancer: A Review
Wong, K. E., Ngai, S. C., Chan, K., Lee, L., Goh, B. H., & Chuah, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00152 · Cited by 270
Mehanny, M., Hathout, R. M., Geneidi, A. S., & Mansour, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.018 · Cited by 190
dos Santos, A. M., Carvalho, S. G., Meneguin, A. B., Sábio, R. M., Gremião, M. P. D., & Chorilli, M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.026 · Cited by 178
Dietary fiber-based colon-targeted delivery systems for polyphenols
Tang, H.-Y., Fang, Z., & Ng, K. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.04.028 · Cited by 147
Metadata
- Authors
- Udompornmongkol, P., & Chiang, B.-H.
- Affiliations
- National Taiwan University (TW)
- Corresponding author
- Chiang, Been-Huang
- ORCID
- Chiang, Been-Huang
- Venue
- Journal of Biomaterials Applications
- Publisher
- SAGE Publications
- Published
- 2015-07-13
- Volume
- 30
- Issue
- 5
- Pages
- 537-546
- ISSN
- 0885-3282 (ISSN-L)
- 1530-8022
- OpenAlex
- W1414029200
- Cited by
- 101
- References
- 45
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 5
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomaterials Applications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- curcumin, polymeric nanoparticles, chitosan, gum arabic, colorectal cancer, drug delivery, encapsulation efficiency, in vitro drug release, cellular uptake, anticancer activity
- MeSH terms
- Antineoplastic Agents, Cell Survival, Colon, Curcumin, Drug Carriers, Gum Arabic, Humans, Hydrolysis, Rectum, Colorectal Neoplasms, Cell Line, Tumor, Chitosan, Nanoparticles
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- Udompornmongkol, P., & Chiang, B.-H. (2015). Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications. Journal of Biomaterials Applications. https://doi.org/10.1177/0885328215594479
