Preparation of a small intestinal submucosa modified polypropylene hybrid mesh via a mussel-inspired polydopamine coating for pelvic reconstruction
Abstract
Pelvic organ prolapse (POP) is a serious health issue that affects many adult women. Surgical treatments for POP patients comprise a common strategy in which scaffold materials are used to reconstruct the prolapsed pelvic. However, the existing materials for pelvic reconstruction cannot meet clinical requirements in terms of biocompatibility, mechanics and immunological rejection. To address these concerns, polypropylene (PP) mesh was selected because of its strong mechanical properties. Small intestinal submucosa (SIS) was used to modify the PP mesh via a mussel-inspired polydopamine coating to enhance its biocompatibility. The scanning electron microscopy (SEM) and atomic force microscopy (AFM) results demonstrated that SIS was successfully conjugated on the surface of the PP mesh. Moreover, the cytotoxicity results indicated that the PP mesh and SIS-modified PP mesh were safe to use. Furthermore, in vivo tests demonstrated that the fibroplasia around the implanted site in the SIS-modified PP mesh group was significantly less than the fibroplasia around the PP mesh group. In addition, the immunohistochemistry staining results indicated that the expression of pro-inflammatory macrophages (M1) was substantially lower and that the expression of pro-healing macrophages (M2) was higher in the SIS-modified PP mesh group. Furthermore, ELISA detection indicated that the expression of IL-1β and IL-6 in the SIS-modified PP mesh group was reduced compared with the PP mesh group. These…
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Surface-immobilized BMP-2 via PDA coating successfully controlled collagen fiber assembly in vitro.
“The surface immobilized BMP-2 via PDA coating successfully controlled collagen fiber assembly in the in vitro environmental”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [84]
In vivo bone regeneration with a PLLA scaffold with PDA-immobilized BMP-2 was significantly better than in control groups without PDA binding BMP-2.
“This scaffold also played an active role in the new bone formation where the in vivo bone regeneration was significantly better than control groups without PDA binding BMP-2.”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [84]
Cites
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138 · cited 1× · see citing works
“The grafts were isolated with a small amount (approximately 5mm) of the surrounding native tissues for histological analysis.(27) As shown in Figure 4, more hyperplastic tissues were identified in the PP group around the implanted site, whereas limited hyperplastic tissue was present in the PP-DOPASIS mesh group.”
MethodBrown, B. N., Valentin, J. E., Stewart-Akers, A. M., McCabe, G. P., & Badylak, S. F. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.040 · Cited by 896 · cited 1× · see citing works
“This finding may be attributed to the natural biomaterial coating, which may reduce the immune reaction provoked by the synthetic materials.(21,28) Furthermore, the ELISA detection results demonstrated that the expression of the inflammatory cytokines IL-1b and IL-6 was dramatically lower in the PP-DOPA-SIS mesh-impla…”
BackgroundYu, X., Walsh, J., & Wei, M. (2014) · RSC Advances · doi:10.1039/c3ra44137g · Cited by 68 · see citing works
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Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
“Ge and coworkers [83] developed a small intestinal submucosa (SIS) modified polypropylene (PP) scaffold via the PDA-coated technology for pelvic reconstruction.”
BackgroundPolydopamine Applications in Biomedicine and Environmental Science
Omidian, H., & Wilson, R. L. (2024) · Materials · doi:10.3390/ma17163916 · Cited by 47 · see citing works
- Authors
- Ge, L., Liu, L., Wei, H., Du, L., Chen, S., Huang, Y., & Huang, R.
- Affiliations
- Chongqing Academy of Animal Science (CN)
- Chongqing Maternal and Child Health Hospital (CN)
- Sichuan University (CN)
- Southwest University (CN)
- Southern Medical University (CN)
- West Anhui University (CN)
- Corresponding author
- Huang, Renshu
- Venue
- Journal of Biomaterials Applications
- Publisher
- SAGE Publications
- Published
- 2016-01-21
- Volume
- 30
- Issue
- 9
- Pages
- 1385-1391
- ISSN
- 0885-3282 (ISSN-L)
- 1530-8022
- OpenAlex
- W2314996503
- Cited by
- 19
- References
- 3
- Citations by year
- 2026: 2 · 2024: 4 · 2022: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomaterials Applications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Keywords
- pelvic organ prolapse, pelvic reconstruction, small intestinal submucosa, polypropylene mesh, hybrid meshes, polydopamine coating, mussel-inspired surface modification, biocompatibility, macrophage polarization, M1/M2 macrophages, IL-1β, interleukin-6, fibroplasia, scaffold materials
- MeSH terms
- Animals, Cell Line, Female, Indoles, Intestinal Mucosa, Materials Testing, Polymers, Polypropylenes, Surgical Mesh, Swine, Interleukin-6, Rats, Sprague-Dawley, Coated Materials, Biocompatible, Biomimetic Materials, Bivalvia, Mice, Interleukin-1beta, Tissue Scaffolds
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