Cited by 48Polymer Surface Interaction StudiesBone Tissue Engineering MaterialsConducting polymers and applications

Polydopamine Applications in Biomedicine and Environmental Science

Open access
Omidian, Hossein, Wilson, Renae L.·2024·Materials

Abstract

This manuscript explores the multifaceted applications of polydopamine (PDA) across various scientific and industrial domains. It covers the chemical aspects of PDA and its potential in bone tissue engineering, implant enhancements, cancer treatment, and nanotechnology. The manuscript investigates PDA's roles in tissue engineering, cell culture technologies, surface modifications, drug delivery systems, and sensing techniques. Additionally, it highlights PDA's contributions to microfabrication, nanoengineering, and environmental applications. Through detailed testing and assessment, the study identifies limitations in PDA-related research, such as synthesis complexity, incomplete mechanistic understanding, and biocompatibility variability. It also proposes future research directions aimed at improving synthesis techniques, expanding biomedical applications, and enhancing sensing technologies to optimize PDA's efficacy and scalability.

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Crossref · 10.3390/ma17163916

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149 of 149 references verified0 citation errors · 0 not checkable

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  • Coating adhesion durability, wear resistance, interfacial degradation, batch-to-batch reproducibility, and the biological safety of degradation products remain critical issues before PDA-modified implants or scaffolds can be considered clinically mature.

    “In particular, coating adhesion durability, wear resistance, interfacial degradation, batch-to-batch reproducibility, and the biological safety of degradation products remain critical issues before PDA-modified implants or scaffolds can be considered clinically mature.36,40,41”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [41]

    The Implant Enhancements section (Section 4; page unavailable) identifies coating durability and long-term clinical performance as unresolved, while Section 15 identifies batch consistency and the safety implications of poorly understood degradation products. The Bone Tissue Engineering section (Section 3; page unavailable) also flags wear debris and degradation behavior. The copy does not specifically identify wear resistance or interfacial degradation as critical barriers for PDA-modified implants or scaffolds, so the full list is only partially supported. (LLM, conf=0.86)

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  • The extent of signal enhancement across different detection modalities, including electrochemical, SERS, and colorimetric or fluorescence-based methods, is strongly dependent on nanostructure design, reporter selection, and experimental conditions.

    “It should be noted that the extent of signal enhancement across different detection modalities, including electrochemical, surface-enhanced Raman scattering (SERS), and colorimetric or fluorescence-based methods, is strongly dependent on nanostructure design, reporter selection, and experimental conditions.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [41]

    Section 9 (page unavailable) describes enhanced sensing across SERS, electrochemical, colorimetric, and fluorescence-based platforms, and says PDA application protocols still need optimization. It links some improvements to sensor design, but does not establish that the extent of signal enhancement is strongly dependent on reporter selection or experimental conditions across these modalities. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • Despite high analytical sensitivity under controlled buffer conditions, translation of PDA-based sensing platforms to real salivary samples remains challenging.

    “Despite the high analytical sensitivity achieved by PDA-based sensing platforms under controlled buffer conditions,41,95 the translation of these systems to real salivary samples remains challenging.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [41]

    Section 9 reports high sensitivity for several PDA-based sensors, including low detection limits. It does not establish that those results were obtained under controlled buffer conditions, a qualifier in the clause carrying the citation. The subsequent point about real salivary samples is not directly attached to this citation. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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Authors
Omidian, H., & Wilson, R. L.
Affiliations
Nova Southeastern University (US)
Corresponding author
Omidian, Hossein
Venue
Materials
Publisher
MDPI AG
Published
2024-08-07
Volume
17
Issue
16
Pages
3916
ISSN
1996-1944 (ISSN-L)
OpenAlex
W4401389035
Cited by
47
References
149
Citations by year
2026: 29 · 2025: 18
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Materials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
Keywords
polydopamine, bone tissue engineering, implant surface modification, cancer therapy, drug delivery systems, cell culture, sensor technology, microfabrication, nanoengineering, environmental applications, biocompatibility

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