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Cited by 20Birth, Development, and HealthMaternal Mental Health During Pregnancy and PostpartumStress Responses and Cortisol

Prenatal Programming of Postnatal Susceptibility to Memory Impairments: A Developmental Double Jeopardy

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Grant, Kerry-Ann, Sandman, Curt A., Wing, Deborah A., Dmitrieva, Julia, Davis, Elysia Poggi·2015·Psychological Science
DOI 10.1177/0956797615580299PMC PMC4504787
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Abstract

In the study reported here, we examined the effects of fetal exposure to a synthetic stress hormone (synthetic glucocorticoids) on children’s susceptibility to postnatal sociodemographic adversity. We recruited children who were born healthy and at term. Twenty-six had been treated with steroid hormones (glucocorticoids) during the prenatal period, and 85 had not. Only children exposed to both prenatal stress hormones and postnatal sociodemographic adversity showed impaired performance on standardized tests of memory function. The association was specific to long-term memory. General intellectual functioning and expressive language were not affected by fetal glucocorticoid exposure. Results were independent of maternal intelligence and maternal depression at the time of the study. These findings are consistent with a vulnerability-stress model: Prenatal exposure to synthetic stress hormones is associated with increased susceptibility to subsequent adversity, with consequences for cognitive functioning that persist 6 to 10 years after birth.

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  • Children exposed to both prenatal stress hormones and sociodemographic adversity showed impaired performance on standardized tests of long-term memory function, independent of maternal intelligence and concurrent maternal depression.

    “Children exposed to both prenatal stress hormones and sociodemographic adversity showed impaired performance on standardized tests of long-term memory function, these results being independent of maternal intelligence and concurrent maternal depression [113].”

    From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [113]

  • Exposure to synthetic stress hormones may be associated with increased susceptibility to subsequent adversity with consequences for cognitive functioning that persist for six to 10 years after birth.

    “These findings suggest that exposure to synthetic stress hormones may be associated with increased susceptibility to subsequent adversity with consequences for cognitive functioning that persist for six to 10 years after birth [113].”

    From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [113]

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Authors
Grant, K.-A., Sandman, C. A., Wing, D. A., Dmitrieva, J., & Davis, E. P.
Affiliations
  • University of California, Irvine (US)
  • University of Denver (US)
Corresponding author
Davis, Elysia Poggi
ORCID
Venue
Psychological Science
Publisher
SAGE Publications
Published
2015-06-10
Volume
26
Issue
7
Pages
1054-1062
ISSN
  • 0956-7976 (ISSN-L)
  • 1467-9280
DOI
10.1177/0956797615580299
PMC
PMC4504787
OpenAlex
W1947295628
Cited by
20
References
7
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2017: 5 · 2016: 5
FWCI
3.33
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Psychological Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • University of California, Irvine
  • National Institute of Mental Health (MH96889, P50MH096889)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-50662, R01HD065823, R01HD050662, HD-6582)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
prenatal glucocorticoid exposure, synthetic corticosteroids, memory impairment, long-term memory, vulnerability-stress model, maternal depression, maternal intelligence
MeSH terms
Child, Cognition, Disease Susceptibility, Female, Glucocorticoids, Humans, Male, Memory Disorders, Pregnancy, Prenatal Exposure Delayed Effects, Regression Analysis, Memory, Long-Term

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