The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case–control study within LUMINA, a multiethnic US cohort (LUMINA LVII)
Open accessAbstract
The objective of this study is to examine the clinical features and outcomes of patients with systemic lupus erythematosus (SLE) whose disease began in adolescence [juvenile-onset SLE (jSLE)] compared with adult-onset patients [adult-onset SLE (aSLE)] from a large multiethnic cohort. Systemic lupus erythematosus patients of African-American, Caucasian, or Hispanic ethnicity and ≥1 year follow-up were studied in two groups: jSLE (diagnosed at ≤18 years); aSLE (diagnosed at 19–50 years; matched for gender and disease duration at enrolment). Sociodemographic data, SLE manifestations, disease activity, damage accrual, SLE-related hospitalizations or emergency room visits, drug utilization, mortality and psychosocial characteristics and quality of life were compared. Data were analysed by univariable and multivariable analyses. Seventy-nine patients were studied (31 jSLE, 48 aSLE); 90% were women. Mean (SD) total disease duration was 6.8 (2.7) years in jSLE and 5.6 (3.3) years in aSLE ( p = 0.077). Mean age at cohort entry was 18.4 (1.8) and 33.9 (9.2) years in jSLE and aSLE respectively. By univariable analysis, jSLE patients were more commonly of African-American descent, were more likely to have renal and neurological involvements, and to accrue renal damage; jSLE patients had lower levels of helplessness and scored higher in the physical component measure of the SF-36 than aSLE patients. Renal involvement [OR = 1.549, 95% CI (1.397–15.856)] and neurological involvement [OR = 1.642, 95% CI (1.689–15.786)] were independently associated with jSLE by multivariable analysis. There was a larger proportion of African-Americans within the jSLE group. After adjusting for ethnicity and follow-up time, jSLE patients experienced more renal and neurological manifestations, with more renal damage. There was a two-fold higher mortality rate in the jSLE group.
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Cites
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Cited by
de Ferranti, S. D., Steinberger, J., Ameduri, R., Baker, A., Gooding, H., Kelly, A. S., Mietus-Snyder, M., Mitsnefes, M. M., Peterson, A. L., St-Pierre, J., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000618 · Cited by 441
Prevalence and burden of pediatric-onset systemic lupus erythematosus
Kamphuis, S., & Silverman, E. D. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.121 · Cited by 360
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Chang, J. C., Xiao, R., Mercer-Rosa, L., Knight, A. M., & Weiss, P. F. (2018) · Lupus · doi:10.1177/0961203318804889 · Cited by 67
Metadata
- Authors
- Tucker, L., Uribe, A., Fernández, M., Vilá, L., McGwin, G., Apte, M., Fessler, B., Bastian, H., Reveille, J., & Alarcón, G.
- Venue
- Lupus
- Publisher
- SAGE Publications
- Published
- 2008-04
- Volume
- 17
- Issue
- 4
- Pages
- 314-322
- ISSN
- 0961-2033 (ISSN-L)
- 1477-0962
- OpenAlex
- W2051573899
- Cited by
- 377
- References
- 21
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case–control study within LUMINA, a multiethnic US cohort (LUMINA LVII). https://app.cochat.ai/papers/10.1177/0961203307087875
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- Tucker, L., Uribe, A., Fernández, M., Vilá, L., McGwin, G., Apte, M., Fessler, B., Bastian, H., Reveille, J., & Alarcón, G. (2008). Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case–control study within LUMINA, a multiethnic US cohort (LUMINA LVII). Lupus. https://doi.org/10.1177/0961203307087875
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