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Cited by 159Extracellular vesicles in diseaseMesenchymal stem cell researchNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.

Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy

Open access
Chang, Yu-Hsun, Wu, Kung-Chi, Harn, Horng-Jyh, Lin, Shinn-Zong, Ding, Dah-Ching·2018·Cell Transplantation
DOI 10.1177/0963689717723636PMC PMC6038041
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Abstract

Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction. Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage destruction and osteophyte formation in the joints. Stem cell therapy may provide a biological treatment alternative to traditional pharmacological therapy. Mesenchymal stem cells (MSCs) are preferred because of their differentiation ability and possible derivation from many adult tissues. In addition, the paracrine effects of MSCs play crucial anti-inflammatory and immunosuppressive roles in immune cells. Extracellular vesicles (EVs) are vital mediators of cell-to-cell communication. Exosomes contain various molecules such as microRNA (miRNA), which mediates biological functions through gene regulation. Therefore, exosomes carrying miRNA or other molecules can enhance the therapeutic effects of MSC transplantation. MSC-derived exosomes have been investigated in various animal models representing stroke, PD, and OA. Exosomes are a subtype of EVs. This review article focuses on the mechanism and therapeutic potential of MSC-derived exosomes in stroke, PD, and OA in basic and clinical aspects.

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Fig. 1. Exosome synthesis and action. A cell membrane is an inward budding and formed multivesicular body (MVB). Exosomes are released after the MVB fuses with the membrane. Exosomes can carry lipids, proteins, and nucleic acids to recipient cells; they act as intercellular communicators and play crucial roles in immune response, neurodegenerative disease, osteoarthritis, and tumor progression.
Fig. 1. Exosome synthesis and action. A cell membrane is an inward budding and formed multivesicular body (MVB). Exosomes are released after the MVB fuses with the membrane. Exosomes can carry lipids, proteins, and nucleic acids to recipient cells; they act as intercellular communicators and play crucial roles in immune response, neurodegenerative disease, osteoarthritis, and tumor progression.CC BY-NC · PubMed Central

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Cites

Show all 205 references

Research works printed but not linked: 12

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Metadata

Authors
Chang, Y.-H., Wu, K.-C., Harn, H.-J., Lin, S.-Z., & Ding, D.-C.
Affiliations
  • Tzu Chi University (TW)
  • Buddhist Tzu Chi General Hospital (TW)
  • Tzu Chi Foundation (TW)
Corresponding author
Ding, Dah-Ching
ORCID
Venue
Cell Transplantation
Publisher
SAGE Publications
Published
2018-03
Volume
27
Issue
3
Pages
349-363
ISSN
  • 0963-6897 (ISSN-L)
  • 1555-3892
DOI
10.1177/0963689717723636
PMC
PMC6038041
OpenAlex
W2801124446
Cited by
159
References
205
Citations by year
2026: 5 · 2025: 16 · 2024: 17 · 2023: 22 · 2022: 32 · 2021: 33 · 2020: 16 · 2019: 14 · 2018: 4
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Transplantation (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
exosomes, mesenchymal stem cells, extracellular vesicles, stroke, Parkinson's disease, osteoarthritis, degenerative diseases, microRNA, stem cell therapy, paracrine effects, cartilage destruction, neurodegeneration, cell-to-cell communication
MeSH terms
Extracellular Vesicles, Animals, Humans, Osteoarthritis, Parkinson Disease, Stem Cells, Stroke, MicroRNAs, Exosomes, Mesenchymal Stem Cells

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