The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
Open accessAbstract
Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction. Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage destruction and osteophyte formation in the joints. Stem cell therapy may provide a biological treatment alternative to traditional pharmacological therapy. Mesenchymal stem cells (MSCs) are preferred because of their differentiation ability and possible derivation from many adult tissues. In addition, the paracrine effects of MSCs play crucial anti-inflammatory and immunosuppressive roles in immune cells. Extracellular vesicles (EVs) are vital mediators of cell-to-cell communication. Exosomes contain various molecules such as microRNA (miRNA), which mediates biological functions through gene regulation. Therefore, exosomes carrying miRNA or other molecules can enhance the therapeutic effects of MSC transplantation. MSC-derived exosomes have been investigated in various animal models representing stroke, PD, and OA. Exosomes are a subtype of EVs. This review article focuses on the mechanism and therapeutic potential of MSC-derived exosomes in stroke, PD, and OA in basic and clinical aspects.
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“The injection of MSC-derived EVs was found more efficient than the use of MSC in treating stroke”
From Skeletal Muscle-Released Extracellular Vesicles: State of the Art (2019) · cites this paper as Chang et al., 2018
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Cited by
Sorted by citations
Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
Mianehsaz, E., Mirzaei, H. R., Mahjoubin-Tehran, M., Rezaee, A., Sahebnasagh, R., Pourhanifeh, M. H., Mirzaei, H., & Hamblin, M. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1445-0 · Cited by 274
Skeletal Muscle-Released Extracellular Vesicles: State of the Art
Rome, S., Forterre, A., Mizgier, M. L., & Bouzakri, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00929 · Cited by 139
Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review
Wu, K.-C., Chang, Y.-H., Ding, D.-C., & Lin, S.-Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312911 · Cited by 33
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Metadata
- Authors
- Chang, Y.-H., Wu, K.-C., Harn, H.-J., Lin, S.-Z., & Ding, D.-C.
- Affiliations
- Tzu Chi University (TW)
- Buddhist Tzu Chi General Hospital (TW)
- Tzu Chi Foundation (TW)
- Corresponding author
- Ding, Dah-Ching
- Venue
- Cell Transplantation
- Publisher
- SAGE Publications
- Published
- 2018-03
- Volume
- 27
- Issue
- 3
- Pages
- 349-363
- ISSN
- 0963-6897 (ISSN-L)
- 1555-3892
- PMC
- PMC6038041
- OpenAlex
- W2801124446
- Cited by
- 159
- References
- 205
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 17 · 2023: 22 · 2022: 32 · 2021: 33 · 2020: 16 · 2019: 14 · 2018: 4
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Transplantation (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, mesenchymal stem cells, extracellular vesicles, stroke, Parkinson's disease, osteoarthritis, degenerative diseases, microRNA, stem cell therapy, paracrine effects, cartilage destruction, neurodegeneration, cell-to-cell communication
- MeSH terms
- Extracellular Vesicles, Animals, Humans, Osteoarthritis, Parkinson Disease, Stem Cells, Stroke, MicroRNAs, Exosomes, Mesenchymal Stem Cells
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