Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023

A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1411587 · Cited by 6,778

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., Larrue, V., Lees, K. R., Medeghri, Z., Machnig, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804656 · Cited by 6,684

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

Goyal, M., Demchuk, A. M., Menon, B. K., Eesa, M., Rempel, J., Thornton, J., Roy, D., Jovin, T. G., Willinsky, R. A., Sapkota, B. L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414905 · Cited by 6,103

Mechanisms of angiogenesis

Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727

Endovascular therapy for ischemic stroke with perfusion-imaging selection.

Campbell, B., Mitchell, P. J., Kleinig, T., Dewey, H., Churilov, L., Yassi, N., Yan, B., Dowling, R., Parsons, M., Oxley, T., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414792 · Cited by 5,432

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001

Overdependence on degraded gist memory in Alzheimer's disease.

Gallo, D. A., Shahid, K. R., Olson, M. A., Solomon, T. M., Schacter, D. L., & Budson, A. E. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.625 · Cited by 4,757

Epidemiology of Parkinson's disease

de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996

B lymphocytes secrete antigen-presenting vesicles.

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481

Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,087

Mesenchymal stem cells as trophic mediators

Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,854

Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors

Felson, D. T., Lawrence, R. C., Dieppe, P. A., Hirsch, R., Helmick, C. G., Jordan, J. M., Kington, R. S., Lane, N. E., Nevitt, M. C., Zhang, Y., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-8-200010170-00016 · Cited by 2,565

Treatment Strategies for Acute Ischemic Stroke Caused by Carotid Artery Occlusion

Li, W., Yin, Q., Xu, G., & Liu, X. (2016) · Interventional Neurology · doi:10.1159/000445304 · Cited by 2,319

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266

Intra-Arterial Mechanical Thrombectomy: An Effective Treatment for Ischemic Stroke Caused by Endocarditis

Sveinsson, O. A., Herrman, L., & Holmin, S. (2016) · Case Reports in Neurology · doi:10.1159/000452213 · Cited by 2,048

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009

Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

Caplan, A. I. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21200 · Cited by 1,956

Parkinson's disease

Lees, A. J., Hardy, J., & Revesz, T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60492-x · Cited by 1,956

Negative Fluid-Attenuated Inversion Recovery- Based Intravenous Thrombolysis Using Recombinant Tissue Plasminogen Activator in Acute Stroke Patients with Unknown Onset Time

Aoki, J., Kimura, K., Shibazaki, K., & Sakamoto, Y. (2013) · Cerebrovascular Diseases Extra · doi:10.1159/000348552 · Cited by 1,929

Mechanisms of Thrombus Formation

Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,818

Mechanisms, challenges and opportunities in stroke

Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1106 · Cited by 1,808

Plasticity in gray and white: neuroimaging changes in brain structure during learning

Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685

The many faces of α-synuclein: from structure and toxicity to therapeutic target

Lashuel, H. A., Overk, C., Oueslati, A., & Masliah, E. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3406 · Cited by 1,684

Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials

Kearney, P. M., Baigent, C., Godwin, J., Halls, H. J., Emberson, J., & Patrono, C. (2006) · BMJ · doi:10.1136/bmj.332.7553.1302 · Cited by 1,440

Physiological and pathological roles for microRNAs in the immune system

O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301

VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain

Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.44 · Cited by 1,251

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Bobrie, A., Colombo, M., Raposo, G., & Théry, C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01225.x · Cited by 1,148

Molecular Characterization of Dendritic Cell-Derived Exosomes

Théry, C., Régnault, A., Garin, J., Wolfers, J., Zitvogel, L., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.599 · Cited by 1,065

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

Xin, H., Li, Y., Cui, Y., Yang, J. J., Zhang, Z. G., & Chopp, M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.152 · Cited by 1,004

Exosomes: secreted vesicles and intercellular communications

Théry, C. (2011) · F1000 Biology Reports · doi:10.3410/b3-15 · Cited by 989

Risk factors and burden of osteoarthritis

Palazzo, C., Nguyen, C., Lefèvre‐Colau, M., Rannou, F., & Poiraudeau, S. (2016) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2016.01.006 · Cited by 964

Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation

Prass, K., Meisel, C., Höflich, C., Braun, J., Halle, E., Wolf, T., Ruscher, K., Victorov, I. V., Priller, J., Dirnagl, U., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021098 · Cited by 937

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919

Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial

Jo, C. H., Lee, Y. G., Shin, W. H., Kim, H., Chai, J. W., Jeong, E. C., Kim, J. E., Shim, H., Shin, J. S., Shin, I. S., et al. (2014) · Stem Cells · doi:10.1002/stem.1634 · Cited by 916

Mesenchymal Stem Cells

Ding, D., Shyu, W., & Lin, S. (2011) · Cell Transplantation · doi:10.3727/096368910x · Cited by 915

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

Xin, H., Li, Y., Buller, B., Katakowski, M., Zhang, Y., Wang, X., Shang, X., Zhang, Z. G., & Chopp, M. (2012) · Stem Cells · doi:10.1002/stem.1129 · Cited by 907

A Neurovascular Niche for Neurogenesis after Stroke

Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878

Proteomic profiling of exosomes: Current perspectives

Simpson, R. J., Jensen, S. S., & Lim, J. W. E. (2008) · PROTEOMICS · doi:10.1002/pmic.200800109 · Cited by 872

Rapid Secretion of Interleukin-1β by Microvesicle Shedding

Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

Weissman, I. L. (2000) · Science · doi:10.1126/science.287.5457.1442 · Cited by 852

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

Gatti, S., Bruno, S., Deregibus, M. C., Sordi, A., Cantaluppi, V., Tetta, C., & Camussi, G. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr015 · Cited by 825

Factors Influencing the Decline in Stroke Mortality: A Statement From the American Heart Association/American Stroke Association

Lackland, D. T., Roccella, E. J., Deutsch, A. F., Fornage, M., George, M. G., Howard, G., Kissela, B. M., Kittner, S. J., Lichtman, J. H., Lisabeth, L. D., et al. (2014) · Stroke · doi:10.1161/01.str.0000437068.30550.cf · Cited by 815

Use of Nonsteroidal Antiinflammatory Drugs: An Update for Clinicians: A Scientific Statement From the American Heart Association

Antman, E. M., Bennett, J. S., Daugherty, A., Furberg, C., Roberts, H., & Taubert, K. A. (2007) · Circulation · doi:10.1161/circulationaha.106.181424 · Cited by 804

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 789

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

Baglio, S. R., Rooijers, K., Koppers‐Lalic, D., Verweij, F. J., Pérez-Lanzón, M., Zini, N., Naaijkens, B. A., Perut, F., Niessen, H. W. M., Baldini, N., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0116-z · Cited by 776

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 746

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

Xin, H., Li, Y., Liu, Z., Wang, X., Shang, X., Cui, Y., Zhang, Z. G., & Chopp, M. (2013) · Stem Cells · doi:10.1002/stem.1409 · Cited by 731

Pathology of Parkinson’s disease

Jellinger, K. A. (1991) · Molecular and Chemical Neuropathology · doi:10.1007/bf03159935 · Cited by 708

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

Prusiner, S. B., Woerman, A. L., Mordes, D. A., Watts, J. C., Rampersaud, R., Berry, D. B., Patel, S. S., Oehler, A., Lowe, J. K., Kravitz, S. N., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514475112 · Cited by 703

Secreted microRNAs: a new form of intercellular communication

Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C.-Y. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 690

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

Zhang, S., Chu, W. C., Lai, R. C., Lim, S. K., Hui, J. H. P., & Toh, W. S. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.06.022 · Cited by 673

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Zhou, Y., Xu, H., Xu, W., Wang, B., Wu, H., Tao, Y., Zhang, B., Wang, M., Mao, F., Yan, Y., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt194 · Cited by 656

Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

Bhatnagar, S., Shinagawa, K., Castellino, F., & Schorey, J. S. (2007) · Blood · doi:10.1182/blood-2007-03-079152 · Cited by 634

Acid sphingomyelinase activity triggers microparticle release from glial cells

Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45 · Cited by 615

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607

Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia

Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., & Verderio, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7268 · Cited by 596

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

Pagonabarraga, J., Kulisevsky, J., Strafella, A. P., & Krack, P. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00019-8 · Cited by 592

Exosomes: immune properties and potential clinical implementations

Chaput, N., & Théry, C. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0233-9 · Cited by 590

An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

Sherer, T., Betarbet, R. S., Stout, A. K., Lund, S. A., Baptista, M. J., Panov, A. V., Cookson, M., & Greenamyre, J. T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07006.2002 · Cited by 586

Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline

Clinton, L. K., Blurton-Jones, M., Myczek, K., Trojanowski, J. Q., & LaFerla, F. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0490-10.2010 · Cited by 576

Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry

Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R., & Jasani, B. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00321-5 · Cited by 555

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

Gui, Y., Liu, H., Zhang, L., Lv, W., & Hu, X. (2015) · Oncotarget · doi:10.18632/oncotarget.6158 · Cited by 552

Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy

Baglio, S. R., Pegtel, D. M., & Baldini, N. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00359 · Cited by 551

Exosomes for drug delivery—A novel application for the mesenchymal stem cell

Lai, R. C., Yeo, R. W. Y., Tan, K. H., & Lim, S. K. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.08.008 · Cited by 546

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

Bondeson, J., Wainwright, S. D., Lauder, S. N., Amos, N., & Hughes, C. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2099 · Cited by 532

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

György, B., Hung, M. E., Breakefield, X. O., & Leonard, J. N. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124630 · Cited by 525

Disease‐specific patterns of locus coeruleus cell loss

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MicroRNA‐140 is expressed in differentiated human articular chondrocytes and modulates interleukin‐1 responses

Miyaki, S., Nakasa, T., Otsuki, S., Grogan, S. P., Higashiyama, R., Inoue, A., Kato, Y., Sato, T., Lotz, M., & Asahara, H. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24745 · Cited by 507

Tumour-released exosomes and their implications in cancer immunity

Iero, M., Valenti, R., Huber, V., Filipazzi, P., Parmiani, G., Fais, S., & Rivoltini, L. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402237 · Cited by 497

Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat.

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Human Tumor-Released Microvesicles Promote the Differentiation of Myeloid Cells with Transforming Growth Factor-β–Mediated Suppressive Activity on T Lymphocytes

Valenti, R., Huber, V., Filipazzi, P., Pilla, L., Sovena, G., Villa, A., Corbelli, A., Fais, S., Parmiani, G., & Rivoltini, L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1819 · Cited by 493

Environmental risk factors and Parkinson's disease: a metaanalysis.

Priyadarshi, A., Khuder, S., Schaub, E., & Priyadarshi, S. (2001) · Environmental Research · doi:10.1006/enrs.2001.4264 · Cited by 481

Recombinant Tissue-Type Plasminogen Activator Use for Ischemic Stroke in the United States

Adeoye, O. M., Hornung, R., Khatri, P., & Kleindorfer, D. (2011) · Stroke · doi:10.1161/strokeaha.110.612358 · Cited by 474

Neurological Diseases in Relation to the Blood–Brain Barrier

Rosenberg, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.197 · Cited by 454

Bone Marrow-Derived Endothelial Progenitor Cells Participate in Cerebral Neovascularization After Focal Cerebral Ischemia in the Adult Mouse

Zhang, Z. G., Zhang, L., Jiang, Q., & Chopp, M. (2002) · Circulation Research · doi:10.1161/hh0302.104460 · Cited by 453

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

Denzer, K., van Eijk, M., Kleijmeer, M. J., Jakobson, E., de Groot, C. H., & Geuze, H. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1259 · Cited by 451

Osteoarthritis: Diagnosis and Treatment

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