The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia
Abstract
The current view on the dopamine (DA) hypothesis of schizophrenia postulates a cortical/subcortical imbalance: subcortical mesolimbic DA projections might be hyperactive, resulting in hyperstimulation of D 2 receptors and positive symptoms, whereas mesocortical DA projections to the prefrontal cortex might be hypoactive, resulting in hypostimulation of D 1 receptors, negative symptoms, and cognitive impairment. Although the subcortical abnormalities are relatively well established now, the evidence for cortical hypodopaminergia is just emerging. This article will review current evidence for prefrontal hypodopaminergia in schizophrenia, with special emphasis on positron emission tomography (PET) studies measuring cortical D 1 receptors in schizophrenia. The presentation of the clinical data will be introduced by a brief overview of the function of prefrontal DA systems, both at the cellular and cognitive level. The impact of antipsychotic drugs on prefrontal DA function will also be reviewed. We will conclude with the formulation of several models of altered prefrontal DA transmission at D 1 receptors in schizophrenia.
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Cites
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Cited by
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
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Levkovitz, Y., Mendlovich, S., Riwkes, S., Braw, Y., Levkovitch-Verbin, H., Gal, G., Fennig, S., Treves, I., & Kron, S. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04666yel · Cited by 387
Revel, F. G., Moreau, J.-L., Pouzet, B., Mory, R., Bradaia, A., Buchy, D., Metzler, V, Chaboz, S., Groebke Zbinden, K., Galley, G., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.57 · Cited by 288
Metadata
- Authors
- Abi-Dargham, A., & Moore, H.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 9
- Issue
- 5
- Pages
- 404-416
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2026522842
- Cited by
- 277
- References
- 112
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
