The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons
Abstract
AMP-activated protein kinase (AMPK) constitutes a molecular hub for cellular metabolic control, common to all eukaryotic cells. Numerous reports have established how AMPK responds to changes in the AMP:ATP ratio as a measure of cellular energy levels. In this way, it integrates control over a number of metabolic enzymes and adapts cellular processes to the current energy status in various cell types, such as muscle and liver cells. The role of AMPK in the development, function, and maintenance of the nervous system, on the other hand, has only recently gained attention. Neurons, while highly metabolically active, have poor capacity for nutrient storage and are thus sensitive to energy fluctuations. Recent reports demonstrate that AMPK may have neuroprotective properties and is activated in neurons by resveratrol but also by metabolic stress in the form of ischemia/hypoxia and glucose deprivation. Novel studies on AMPK also implicate neuronal activity as a critical factor in neurodegeneration. Here we discuss the latest advances in the knowledge of AMPK's role in the metabolic control and survival of excitable cells.
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“It is a brain specific form of diabetes characterized by impaired insulin actions and neuronal insulin resistance [120] that leads to excessive generation and accumulation of amyloid oligomers, a key factor in the development of AD [121].”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [120]
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Metadata
- Authors
- Spasić, M. R., Callaerts, P., & Norga, K. K.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- Laboratory of Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, , Pediatric Hematology and Oncology, Department of Woman & Child, K.U. Leuven, Leuven, Belgium
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2009-04-09
- Volume
- 15
- Issue
- 4
- Pages
- 309-316
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2014734035
- Cited by
- 109
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 11 · 2017: 5 · 2016: 12 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 10
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaams Instituut voor Biotechnologie
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- AMPK, neuronal energy metabolism, neuroprotection, AMP/ATP ratio, resveratrol, hypoxia-ischemia, glucose deprivation, metabolic stress, neuronal activity, neurodegeneration, neuronal survival, excitable cells
- MeSH terms
- Animals, Brain, Brain Chemistry, Cell Survival, Energy Metabolism, Humans, Neurons, Stress, Physiological, Cytoprotection, Hypoxia-Ischemia, Brain, AMP-Activated Protein Kinases
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