Cited by 109Metabolism, Diabetes, and CancerNeuroscience and Neuropharmacology ResearchSirtuins and Resveratrol in Medicine

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AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons

Spasić, Miloš R., Callaerts, Patrick, Norga, Koenraad K.·2009·The Neuroscientist

DOI 10.1177/1073858408327805

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Abstract

AMP-activated protein kinase (AMPK) constitutes a molecular hub for cellular metabolic control, common to all eukaryotic cells. Numerous reports have established how AMPK responds to changes in the AMP:ATP ratio as a measure of cellular energy levels. In this way, it integrates control over a number of metabolic enzymes and adapts cellular processes to the current energy status in various cell types, such as muscle and liver cells. The role of AMPK in the development, function, and maintenance of the nervous system, on the other hand, has only recently gained attention. Neurons, while highly metabolically active, have poor capacity for nutrient storage and are thus sensitive to energy fluctuations. Recent reports demonstrate that AMPK may have neuroprotective properties and is activated in neurons by resveratrol but also by metabolic stress in the form of ischemia/hypoxia and glucose deprivation. Novel studies on AMPK also implicate neuronal activity as a critical factor in neurodegeneration. Here we discuss the latest advances in the knowledge of AMPK's role in the metabolic control and survival of excitable cells.

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Retracted
The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
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Resveratrol stimulates AMP kinase activity in neurons
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Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
Vı́lchez, D., R�os, S., Cifuentes, D., Pujadas, L., Vallès, J., García-Fojeda, B., Criado‐García, O., Fernández-Sánchez, E., Medraño-Fernández, I., Domínguez, J. E., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1998 · Cited by 374
AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation
Culmsee, C., monnig, J., Kemp, B. E., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:1:45 · Cited by 340
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
Xue, B., & Kahn, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113217 · Cited by 338
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333
Cellular Distribution and Developmental Expression of AMP‐Activated Protein Kinase Isoforms in Mouse Central Nervous System
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Authors: Spasić, M. R., Callaerts, P., & Norga, K. K.
Affiliations: Vlaams Instituut voor Biotechnologie (BE)
Laboratory of Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, , Pediatric Hematology and Oncology, Department of Woman & Child, K.U. Leuven, Leuven, Belgium
ORCID: Spasić, Miloš R.
Callaerts, Patrick
Venue: The Neuroscientist
Publisher: SAGE Publications
Published: 2009-04-09
Volume: 15
Issue: 4
Pages: 309-316
ISSN: 1073-8584 (ISSN-L)
1089-4098
DOI: 10.1177/1073858408327805
OpenAlex: W2014734035
Cited by: 109
References: 33
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 11 · 2017: 5 · 2016: 12 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 10
FWCI: 0.64
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The Neuroscientist (publishedVersion)
PubMed (publishedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
KU Leuven
Vlaams Instituut voor Biotechnologie
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: AMPK, neuronal energy metabolism, neuroprotection, AMP/ATP ratio, resveratrol, hypoxia-ischemia, glucose deprivation, metabolic stress, neuronal activity, neurodegeneration, neuronal survival, excitable cells
MeSH terms: Animals, Brain, Brain Chemistry, Cell Survival, Energy Metabolism, Humans, Neurons, Stress, Physiological, Cytoprotection, Hypoxia-Ischemia, Brain, AMP-Activated Protein Kinases

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AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons

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